Automated detection of pulmonary nodules in PET/CT images: Ensemble false-positive reduction using a convolutional neural network technique.

Abstract:

PURPOSE:Automated detection of solitary pulmonary nodules using positron emission tomography (PET) and computed tomography (CT) images shows good sensitivity; however, it is difficult to detect nodules in contact with normal organs, and additional efforts are needed so that the number of false positives (FPs) can be further reduced. In this paper, the authors propose an improved FP-reduction method for the detection of pulmonary nodules in PET/CT images by means of convolutional neural networks (CNNs). METHODS:The overall scheme detects pulmonary nodules using both CT and PET images. In the CT images, a massive region is first detected using an active contour filter, which is a type of contrast enhancement filter that has a deformable kernel shape. Subsequently, high-uptake regions detected by the PET images are merged with the regions detected by the CT images. FP candidates are eliminated using an ensemble method; it consists of two feature extractions, one by shape/metabolic feature analysis and the other by a CNN, followed by a two-step classifier, one step being rule based and the other being based on support vector machines. RESULTS:The authors evaluated the detection performance using 104 PET/CT images collected by a cancer-screening program. The sensitivity in detecting candidates at an initial stage was 97.2%, with 72.8 FPs/case. After performing the proposed FP-reduction method, the sensitivity of detection was 90.1%, with 4.9 FPs/case; the proposed method eliminated approximately half the FPs existing in the previous study. CONCLUSIONS:An improved FP-reduction scheme using CNN technique has been developed for the detection of pulmonary nodules in PET/CT images. The authors' ensemble FP-reduction method eliminated 93% of the FPs; their proposed method using CNN technique eliminates approximately half the FPs existing in the previous study. These results indicate that their method may be useful in the computer-aided detection of pulmonary nodules using PET/CT images.

journal_name

Med Phys

journal_title

Medical physics

authors

Teramoto A,Fujita H,Yamamuro O,Tamaki T

doi

10.1118/1.4948498

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

2821-2827

issue

6

eissn

0094-2405

issn

2473-4209

journal_volume

43

pub_type

杂志文章
  • Evaluation of two methods of predicting MLC leaf positions using EPID measurements.

    abstract::In intensity modulated radiation treatments (IMRT), the position of the field edges and the modulation within the beam are often achieved with a multileaf collimator (MLC). During the MLC calibration process, due to the finite accuracy of leaf position measurements, a systematic error may be introduced to leaf positio...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2335490

    authors: Parent L,Seco J,Evans PM,Dance DR,Fielding A

    更新日期:2006-09-01 00:00:00

  • Experimental assessment of microwave ablation computational modeling with MR thermometry.

    abstract:PURPOSE:Computational models are widely used during the design and characterization of microwave ablation (MWA) devices, and have been proposed for pretreatment planning. Our objective was to assess three-dimensional (3D) transient temperature and ablation profiles predicted by MWA computational models with temperature...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.14318

    authors: Faridi P,Keselman P,Fallahi H,Prakash P

    更新日期:2020-09-01 00:00:00

  • Ultrasound contrast-detail analysis: a preliminary study in human observer performance.

    abstract::Results of a human observer performance study using a new ultrasound contrast-detail (CD) phantom are reported. The new phantom allows estimates of the fundamental statistical uncertainties involved in CD analysis. Results of these experiments show that observers generally considered to be "trained" require experience...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.597147

    authors: Hall TJ,Insana MF,Soller NM,Harrison LA

    更新日期:1993-01-01 00:00:00

  • A new data augmentation method based on local image warping for medical image segmentation.

    abstract:PURPOSE:The segmentation accuracy of medical images was improved by increasing the number of training samples using a local image warping technique. The performance of the proposed method was evaluated in the segmentation of breast masses, prostate and brain tumors, and lung nodules. METHODS:We propose a simple data a...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.14651

    authors: Liu H,Cao H,Song E,Ma G,Xu X,Jin R,Liu T,Liu L,Liu D,Hung CC

    更新日期:2020-12-10 00:00:00

  • Low-dose CT reconstruction using spatially encoded nonlocal penalty.

    abstract:PURPOSE:Computed tomography (CT) is one of the most used imaging modalities for imaging both symptomatic and asymptomatic patients. However, because of the high demand for lower radiation dose during CT scans, the reconstructed image can suffer from noise and artifacts due to the trade-off between the image quality and...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.12523

    authors: Kim K,El Fakhri G,Li Q

    更新日期:2017-10-01 00:00:00

  • Leakage and scatter radiation from a double scattering based proton beamline.

    abstract::Proton beams offer several advantages over conventional radiation techniques for treating cancer and other diseases. These advantages might be negated if the leakage and scatter radiation from the beamline and patient are too large. Although the leakage and scatter radiation for the double scattering proton beamlines ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2805086

    authors: Moyers MF,Benton ER,Ghebremedhin A,Coutrakon G

    更新日期:2008-01-01 00:00:00

  • Absolute diameter measurements of coronary arteries based on the first zero crossing of the Fourier spectrum.

    abstract::Current edge detection methods used to determine coronary artery dimensions from digital (DSA) images suffer a strong dependence on the system's modulation transfer function (MTF). The videodensitometric algorithms are less sensitive to MTF blurring, yet still result in an overestimation of the vessel size of 10% to 2...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.596370

    authors: Weber DM

    更新日期:1989-03-01 00:00:00

  • Principles in positioning cross-projecting lasers.

    abstract::With the increased sophistication of lasers used for patient positioning in radiotherapy comes increased possibilities for mistakes in installing the lasers, which can result in serious patient positioning errors. Two principles must be followed when mounting cross-projecting lasers: (1) the horizontal line must be on...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.594960

    authors: Thomadsen BR

    更新日期:1981-05-01 00:00:00

  • Evaluations of magnetic resonance imaging parameters with simple phantoms.

    abstract::Imaging parameters associated with a clinical magnetic resonance imaging (MRI) system, evaluated with the use of simple and inexpensive phantoms, are described in evaluation of a clinical MRI system. Images, obtained with a Diasonics 0.35-T MRI system using an elliptical whole-body radio frequency coil, are presented ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.595894

    authors: Brateman L,Jennings LW,Nunnally RL,Vaughan JT

    更新日期:1986-07-01 00:00:00

  • Reconstruction of electron spectra from depth doses with adaptive regularization.

    abstract::Electron spectral reconstruction of medical accelerators from measured depth doses is a practical method for providing the input initial phase space distribution at the patient surface that is required by Monte Carlo treatment planning systems. The posed inverse problem of spectral reconstruction is ill conditioned an...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2161404

    authors: Wei J,Sandison GA,Chvetsov AV

    更新日期:2006-02-01 00:00:00

  • A sparse orthogonal collimator for small animal intensity-modulated radiation therapy part I: Planning system development and commissioning.

    abstract:PURPOSE:To achieve more translatable preclinical research results, small animal irradiation needs to more closely simulate human radiotherapy. Although the clinical gold standard is intensity-modulated radiation therapy (IMRT), the direct translation of this method for small animals is impractical. In this study we des...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.13872

    authors: Woods K,Nguyen D,Neph R,Ruan D,O'Connor D,Sheng K

    更新日期:2019-12-01 00:00:00

  • Novel detector design for reducing intercell x-ray cross-talk in the variable resolution x-ray CT scanner: a Monte Carlo study.

    abstract:PURPOSE:The variable resolution x-ray (VRX) CT scanner provides substantial improvement in the spatial resolution by matching the scanner's field of view (FOV) to the size of the object being imaged. Intercell x-ray cross-talk is one of the most important factors limiting the spatial resolution of the VRX detector. In ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3555035

    authors: Arabi H,Asl AR,Ay MR,Zaidi H

    更新日期:2011-03-01 00:00:00

  • A nonvoxel-based dose convolution/superposition algorithm optimized for scalable GPU architectures.

    abstract:PURPOSE:Real-time adaptive planning and treatment has been infeasible due in part to its high computational complexity. There have been many recent efforts to utilize graphics processing units (GPUs) to accelerate the computational performance and dose accuracy in radiation therapy. Data structure and memory access pat...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4895822

    authors: Neylon J,Sheng K,Yu V,Chen Q,Low DA,Kupelian P,Santhanam A

    更新日期:2014-10-01 00:00:00

  • Displacement-based binning of time-dependent computed tomography image data sets.

    abstract::Respiration can cause tumors in the thorax or abdomen to move by as much as 3 cm; this movement can adversely affect the planning and delivery of radiation treatment. Several techniques have been used to compensate for respiratory motion, but all have shortcomings. Manufacturers of computed tomography (CT) equipment h...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2044427

    authors: Fitzpatrick MJ,Starkschall G,Antolak JA,Fu J,Shukla H,Keall PJ,Klahr P,Mohan R

    更新日期:2006-01-01 00:00:00

  • Experimental investigation on the accuracy of plastic scintillators and of the spectrum discrimination method in small photon fields.

    abstract:PURPOSE:To investigate the accuracy of output factor measurements using a commercial (Exradin W1, SI) and a prototype, "in-house" developed, plastic scintillation dosimeter (PSD) in small photon fields. METHODS:Repetitive detector-specific output factor OFdet measurements were performed in water (parallel to the CAX) ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.12064

    authors: Papaconstadopoulos P,Archambault L,Seuntjens J

    更新日期:2017-02-01 00:00:00

  • Kilovoltage stereotactic radiosurgery for age-related macular degeneration: assessment of optic nerve dose and patient effective dose.

    abstract::Age-related macular degeneration (AMD) is a leading cause for vision loss for people over the age of 65 in the United States and a major health problem worldwide. Research for new treatments of the wet form of the disease using kilovoltage stereotactic radiosurgery is currently underway at Oraya Therapeutics, Inc. In ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3168554

    authors: Hanlon J,Lee C,Chell E,Gertner M,Hansen S,Howell RW,Bolch WE

    更新日期:2009-08-01 00:00:00

  • Direct cone-beam cardiac reconstruction algorithm with cardiac banding artifact correction.

    abstract::Multislice helical computed tomography (CT) is a promising noninvasive technique for coronary artery imaging. Various factors can cause inconsistencies in cardiac CT data, which can result in degraded image quality. These inconsistencies may be the result of the patient physiology (e.g., heart rate variations), the na...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2163247

    authors: Taguchi K,Chiang BS,Hein IA

    更新日期:2006-02-01 00:00:00

  • WE-F-211-01: The Evolving Landscape of Scientific Publishing.

    abstract::The dissemination of scientific advances has changed little since the first peer-reviewed journal was published in 1665 - that is, until this past decade. The print journal, delivered by mail and stored on office shelves and in library reading rooms around the world, has been transformed by immediate, on-demand access...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4736173

    authors: Armato S,Hendee W,Marshall C,Curran B

    更新日期:2012-06-01 00:00:00

  • SU-E-T-622: A Rapid Hybrid VMAT-IMRT Planning Method Using an Abbreviated Beam Angle Optimization Search.

    abstract:PURPOSE:To generate hybrid VMAT-IMRT treatment plans by utilizing an IMRT beam-angle-optimality (BAO) search under a commercially available TPS without the aid of custom optimization software or high performance computing. METHODS:The high dose modulation provided by IMRT beams can be exploited to improve the quality ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4735712

    authors: Schulze D,Ionascu D,Tyagi N

    更新日期:2012-06-01 00:00:00

  • Soft-tissue detectability in cone-beam CT: evaluation by 2AFC tests in relation to physical performance metrics.

    abstract::Soft-tissue detectability in cone-beam computed tomography (CBCT) was evaluated via two-alternative forced-choice (2AFC) tests. Investigations included the dependence of detectability on radiation dose, the influence of the asymmetric three-dimensional (3D) noise-power spectrum (NPS) in axial and sagittal or coronal p...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2790586

    authors: Tward DJ,Siewerdsen JH,Daly MJ,Richard S,Moseley DJ,Jaffray DA,Paul NS

    更新日期:2007-11-01 00:00:00

  • Quantitative study of focused ultrasound enhanced doxorubicin delivery to prostate tumor in vivo with MRI guidance.

    abstract:PURPOSE:The purpose of this study was to investigate the potential of MR-guided pulsed focused ultrasound (pFUS) for the enhancement of drug uptake in prostate tumors in vivo using doxorubicin (Dox). METHODS:An antitumor drug Dox, an orthotopic animal prostate tumor model using human prostate cancer, LNCaP cell line, ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4705346

    authors: Chen X,Cvetkovic D,Ma CM,Chen L

    更新日期:2012-05-01 00:00:00

  • An iterative technique to segment PET lesions using a Monte Carlo based mathematical model.

    abstract:PURPOSE:The need for an accurate lesion segmentation tool in 18FDG PET is a prerequisite for the estimation of lesion response to therapy, for radionuclide dosimetry, and for the application of 18FDG PET to radiotherapy planning. In this work, the authors have developed an iterative method based on a mathematical fit d...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3222732

    authors: Nehmeh SA,El-Zeftawy H,Greco C,Schwartz J,Erdi YE,Kirov A,Schmidtlein CR,Gyau AB,Larson SM,Humm JL

    更新日期:2009-10-01 00:00:00

  • Assessment of flat panel LCD primary class display performance based on AAPM TG 18 acceptance protocol.

    abstract::The image display is an important component of the Picture Archiving and Communication System (PACS) and of digital imaging in general. In this paper, we assess the display performance of 32 different flat panel LCD devices, in terms of their reflection, luminance response, luminance uniformity, resolution, noise, vei...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1764946

    authors: Jung H,Kim HJ,Kang WS,Yoo SK,Fujioka K,Hasegawa M,Samei E

    更新日期:2004-07-01 00:00:00

  • Technical Note: 4D cone-beam CT reconstruction from sparse-view CBCT data for daily motion assessment in pencil beam scanned proton therapy (PBS-PT).

    abstract:PURPOSE:The number of pencil beam scanned proton therapy (PBS-PT) facilities equipped with cone-beam computed tomography (CBCT) imaging treating thoracic indications is constantly rising. To enable daily internal motion monitoring during PBS-PT treatments of thoracic tumors, we assess the performance of Motion-Aware Re...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.14521

    authors: den Otter LA,Chen K,Janssens G,Meijers A,Both S,Langendijk JA,Rosen LR,Wu HT,Knopf AC

    更新日期:2020-12-01 00:00:00

  • Interleaf leakage for 5 and 10 mm dynamic multileaf collimation systems incorporating patient motion.

    abstract::Use of dynamic multileaf collimation (DMLC) for intensity modulated radiation therapy (IMRT) is accelerating. Delivery systems have the ailment of interleaf leakage (IL). This is compounded by the inefficiency of IMRT delivery, estimated to be a factor of 5 for DMLC. With IL on the order of 4%, it is possible to deliv...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1388216

    authors: Klein EE,Low DA

    更新日期:2001-08-01 00:00:00

  • Effect of surrounding vasculature on intravoxel BOLD signal.

    abstract:PURPOSE:The nonlocal influence from distant magnetization will affect the magnetic field at a voxel in question. Existing reports on BOLD simulation only consider vasculature inside a single voxel, thus omitting the contribution from the surrounding regions. In this article, the authors study the effect of the surround...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3366251

    authors: Chen Z,Caprihan A,Calhoun V

    更新日期:2010-04-01 00:00:00

  • Experimental study of the relationship between the base impedance and its time derivative in impedance plethysmography.

    abstract::Transthoracic electrical impedance Z consists of a constant baseline component Z0 and the time variable component delta Z such that Z = Z0 + delta Z. The first time derivative of Z has a negative peak, the magnitude of which is (dZ/dt)min. Measurements of 170 volunteers show that (dZ/dt)min is a function of the consta...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.594910

    authors: Djordjevich L,Sadove MS

    更新日期:1981-01-01 00:00:00

  • Four-dimensional cone-beam computed tomography and digital tomosynthesis reconstructions using respiratory signals extracted from transcutaneously inserted metal markers for liver SBRT.

    abstract:PURPOSE:Respiration-induced intrafraction target motion is a concern in liver cancer radiotherapy, especially in stereotactic body radiotherapy (SBRT), and therefore, verification of its motion is necessary. An effective means to localize the liver cancer is to insert metal fiducial markers to or near the tumor with si...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3544369

    authors: Park JC,Park SH,Kim JH,Yoon SM,Kim SS,Kim JS,Liu Z,Watkins T,Song WY

    更新日期:2011-02-01 00:00:00

  • An efficient protocol for radiochromic film dosimetry combining calibration and measurement in a single scan.

    abstract:PURPOSE:Radiochromic film provides dose measurement at high spatial resolution, but often is not preferred for routine evaluation of patient-specific intensity modulated radiation therapy (IMRT) plans owing to ease-of-use factors. The authors have established an efficient protocol that combines calibration and measurem...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4754797

    authors: Lewis D,Micke A,Yu X,Chan MF

    更新日期:2012-10-01 00:00:00

  • The prediction of breast cancer biopsy outcomes using two CAD approaches that both emphasize an intelligible decision process.

    abstract::Mammography is the most effective method for breast cancer screening available today. However, the low positive predictive value of breast biopsy resulting from mammogram interpretation leads to approximately 70% unnecessary biopsies with benign outcomes. To reduce the high number of unnecessary breast biopsies, sever...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2786864

    authors: Elter M,Schulz-Wendtland R,Wittenberg T

    更新日期:2007-11-01 00:00:00