Abstract:
:Colorectal cancer (CRC) is a common malignancy with high morbidity and mortality worldwide. To date, chemotherapy plays an important role in the treatment of CRC patients. Multidrug resistance (MDR) is one of the major hurdles in chemotherapy for CRC, and the underlying mechanisms need to be explored. Studies have demonstrated that Wnt/β-catenin signaling plays a critical role in oncogenesis and tumor development, and its function in inhibiting apoptosis could facilitate tumor chemoresistance. Recent investigations have also suggested the regulatory effects of the Wnt/β-catenin signaling pathway in response to chemotherapeutic agents in CRC. Here, we particularly focus on reviewing the evidences suggesting the mechanisms of Wnt/β-catenin signaling in the chemoresistance modulation of colorectal cancer.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Yuan S,Tao F,Zhang X,Zhang Y,Sun X,Wu Ddoi
10.1155/2020/9390878subject
Has Abstractpub_date
2020-03-18 00:00:00pages
9390878eissn
2314-6133issn
2314-6141journal_volume
2020pub_type
杂志文章,评审abstract::The cytosolic isozyme of phosphoenolpyruvate carboxykinase (PCK1) was the first rate-limiting enzyme in the gluconeogenesis pathway, which exerted a critical role in maintaining the blood glucose levels. PCK1 has been established to be involved in various physiological and pathological processes, including glucose met...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3858465
更新日期:2020-02-12 00:00:00
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/537941
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journal_title:BioMed research international
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doi:10.1155/2020/8018525
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1057943
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4658024
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7814287
更新日期:2019-12-07 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2174824
更新日期:2018-11-05 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2014/261761
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1069585
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4273290
更新日期:2019-03-04 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6182464
更新日期:2020-06-07 00:00:00
abstract::Our previous studies have demonstrated that diabetes-induced oxidative stress alters homeostasis of retinal nerve growth factor (NGF) resulting in accumulation of its precursor, proNGF, at the expense of NGF which plays a critical role in preserving neuronal and retinal function. This imbalance coincided with retinal ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/571456
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1407167
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/1868254
更新日期:2018-03-11 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/1729138
更新日期:2019-04-22 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/9060143
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2698570
更新日期:2019-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/745410
更新日期:2015-01-01 00:00:00
abstract::The presence of acquired mutations within the JAK2, CALR, and MPL genes in the majority of patients with myeloproliferative neoplasms (MPN) affords the opportunity to utilise these mutations as markers of minimal residual disease (MRD). Reduction of the mutated allele burden has been reported in response to a number o...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/7241591
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8158974
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5095934
更新日期:2019-12-28 00:00:00