Abstract：
:Single nucleotide polymorphism (SNP) typing offers promise to forensic genetics. Various strategies and panels for analyzing SNP markers for individual identification have been published. However, the best panels with fewer identity SNPs for all major population groups are still under discussion. This study aimed to find more autosomal SNPs with high heterozygosity for individual identification among Asian populations. Ninety-six autosomal SNPs of 502 DNA samples from unrelated individuals of five population groups (208 Taiwanese Han, 83 Filipinos, 62 Thais, 69 Indonesians, and 80 individuals with European, Near Eastern, or South Asian ancestry) were analyzed using arrays in an initial screening, and 75 SNPs (group A, 46 newly selected SNPs; groups B, 29 SNPs based on a previous SNP panel) were selected for further statistical analyses. Some SNPs with high heterozygosity from Asian populations were identified. The combined random match probability of the best 40 and 45 SNPs was between 3.16 × 10(-17) and 7.75 × 10(-17) and between 2.33 × 10(-19) and 7.00 × 10(-19), respectively, in all five populations. These loci offer comparable power to short tandem repeats (STRs) for routine forensic profiling. In this study, we demonstrated the population genetic characteristics and forensic parameters of 75 SNPs with high heterozygosity from five population groups. This SNPs panel can provide valuable genotypic information and can be helpful in forensic casework for individual identification among these populations.
journal_name
Int J Legal Medjournal_title
International journal of legal medicineauthors
Hwa HL,Wu LS,Lin CY,Huang TY,Yin HI,Tseng LH,Lee JCdoi
10.1007/s00414-015-1250-ysubject
Has Abstractpub_date
2016-01-01 00:00:00pages
81-9issue
1eissn
0937-9827issn
1437-1596pii
10.1007/s00414-015-1250-yjournal_volume
130pub_type
杂志文章abstract：:Methadone plays an increasing role in drug-related deaths in Hamburg. To find out whether intravenous application of methadone plays a relevant role in methadone-related deaths, body fluids of all methadone-positive cases (n=130) and three buprenorphine-positive cases where a urine sample was available (n=58+3) were i...
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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journal_title：International journal of legal medicine
pub_type： 杂志文章,评审
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-015-1232-0
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journal_title：International journal of legal medicine
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journal_title：International journal of legal medicine
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doi：10.1007/s00414-014-1066-1
更新日期：2015-01-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-008-0249-z
更新日期：2009-01-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2001-01-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050177
更新日期：1998-01-01 00:00:00
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更新日期：2013-03-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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journal_title：International journal of legal medicine
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更新日期：1996-01-01 00:00:00
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