Apathy and emotion-based decision-making in amnesic mild cognitive impairment and Alzheimer's disease.

Abstract:

BACKGROUND:Apathy and reduced emotion-based decision-making are two behavioral modifications independently described in Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). OBJECTIVES:The aims of this study were to investigate decision-making based on emotional feedback processing in AD and aMCI and to study the impact of reduced decision-making performances on apathy. METHODS:We recruited 20 patients with AD, 20 participants with aMCI, and 20 healthy controls. All participants completed the Lille apathy rating scale (LARS) and the Iowa gambling task (IGT). RESULTS:Both aMCI and AD participants had reduced performances on the IGT and were more apathetic compared to controls without any difference between aMCI and AD groups. For the entire sample, LARS initiation dimension was related to IGT disadvantageous decision-making profile. CONCLUSIONS:We provide the first study showing that both aMCI and AD individuals make less profitable decisions than controls, whereas aMCI and AD did not differ. Disadvantageous decision-making profile on the IGT was associated with higher level of apathy on the action initiation dimension. The role of an abnormal IGT performance as a risk factor for the development of apathy needs to be investigated in other clinical populations and in normal aging.

journal_name

Behav Neurol

journal_title

Behavioural neurology

authors

Bayard S,Jacus JP,Raffard S,Gely-Nargeot MC

doi

10.1155/2014/231469

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

231469

eissn

0953-4180

issn

1875-8584

journal_volume

2014

pub_type

杂志文章
  • Pharmacokinetics of Anti-epileptic Drugs and their Clinical Significance.

    abstract::The serum concentration achieved and maintained following the administration of a fixed drug dosage is a direct consequence of the interactions of a wide variety of interrelated processes, including drug absorption, distribution, metabolism, and excretion, and the physiological status of the patient. These interrelati...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1990-31S102

    authors: Johannessen SI

    更新日期:1990-01-01 00:00:00

  • Unpicking the semantic impairment in Alzheimer's disease: qualitative changes with disease severity.

    abstract::Despite a vast literature examining semantic impairment in Alzheimer's disease (AD), consensus regarding the nature of the deficit remains elusive. We re-considered this issue in the context of a framework that assumes semantic cognition can break down in two ways: (1) core semantic representations can degrade or (2) ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-2012-0346

    authors: Corbett F,Jefferies E,Burns A,Ralph MA

    更新日期:2012-01-01 00:00:00

  • Can tactile neglect occur at an intra-limb level? Vibrotactile reaction times in patients with right hemisphere damage.

    abstract::Visual reaction time (RT) studies on patients with right hemisphere (RH) damage have demonstrated that the attentional imbalance to stimuli occupying left and right positions exists even within the "intact" ipsilesional hemifield. The purpose of the present study was to test whether such patients might also exhibit re...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1994-7204

    authors: Mattingley JB,Bradshaw JL

    更新日期:1994-01-01 00:00:00

  • Heterogeneity of radiological spectrum in tacrolimus-associated encephalopathy after lung transplantation.

    abstract:BACKGROUND:Tacrolimus-associated encephalopathy (TAC-E) is usually described under the term of posterior reversible encephalopathy syndrome (PRES). However, a large amount of data has suggested that TAC-E is not a homogenous entity: indeed, TAC-E which is often presented with atypical and potentially misleading imaging...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2014/931808

    authors: Wu Q,Marescaux C,Qin X,Kessler R,Yang J

    更新日期:2014-01-01 00:00:00

  • Efficacy of a Computer-Assisted Cognitive Rehabilitation Intervention in Relapsing-Remitting Multiple Sclerosis Patients: A Multicenter Randomized Controlled Trial.

    abstract::Cognitive impairment is frequently encountered in multiple sclerosis (MS) affecting between 40-65% of individuals, irrespective of disease duration and severity of physical disability. In the present multicenter randomized controlled trial, fifty-eight clinically stable RRMS patients with mild to moderate cognitive im...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1155/2017/5919841

    authors: Messinis L,Nasios G,Kosmidis MH,Zampakis P,Malefaki S,Ntoskou K,Nousia A,Bakirtzis C,Grigoriadis N,Gourzis P,Papathanasopoulos P

    更新日期:2017-01-01 00:00:00

  • Prefrontal abilities.

    abstract::The neuroanatomical region that has most prominently altered with the advancing cognitive competency of the human is the prefrontal cortex, particularly the rostral extreme. While the prefrontal cortex does not appear to contain the neural networks that carry out cognitive activities, the management of these high leve...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1993-6202

    authors: Benson DF

    更新日期:1993-01-01 00:00:00

  • A Proposed Neurological Interpretation of Language Evolution.

    abstract::Since the very beginning of the aphasia history it has been well established that there are two major aphasic syndromes (Wernicke's-type and Broca's-type aphasia); each one of them is related to the disturbance at a specific linguistic level (lexical/semantic and grammatical) and associated with a particular brain dam...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.1155/2015/872487

    authors: Ardila A

    更新日期:2015-01-01 00:00:00

  • Optimizing Neuropsychological Assessments for Cognitive, Behavioral, and Functional Impairment Classification: A Machine Learning Study.

    abstract::Subjects with Alzheimer's disease (AD) show loss of cognitive functions and change in behavioral and functional state affecting the quality of their daily life and that of their families and caregivers. A neuropsychological assessment plays a crucial role in detecting such changes from normal conditions. However, desp...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2017/1850909

    authors: Battista P,Salvatore C,Castiglioni I

    更新日期:2017-01-01 00:00:00

  • Trials of pharmacological interventions for Tourette syndrome: a systematic review.

    abstract:INTRODUCTION:Gilles de la Tourette Syndrome (GTS) is a childhood-onset hyperkinetic movement disorder defined by the chronic presence of multiple motor tics and at least one vocal tic and often complicated by co-morbid behavioural problems. The pharmacological treatment of GTS focuses on the modulation of monoaminergic...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.3233/BEN-2012-120269

    authors: Waldon K,Hill J,Termine C,Balottin U,Cavanna AE

    更新日期:2013-01-01 00:00:00

  • Antiepileptic Drug Nonadherence and Its Predictors among People with Epilepsy.

    abstract::Introduction. Antiepileptic drugs are effective in the treatment of epilepsy to the extent that about 70% of people with epilepsy can be seizure-free, but poor adherence to medication is major problem to sustained remission and functional restoration. The aim of this study was to assess the prevalence and associated f...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2016/3189108

    authors: Getnet A,Woldeyohannes SM,Bekana L,Mekonen T,Fekadu W,Menberu M,Yimer S,Assaye A,Belete A,Belete H

    更新日期:2016-01-01 00:00:00

  • Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo.

    abstract::Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography (PET) with (11)carbon-labelled Pittsburgh Compound-B ((11)C-PIB), ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.3233/BEN-2009-0232

    authors: Rabinovici GD,Jagust WJ

    更新日期:2009-01-01 00:00:00

  • Impaired initiation but not execution of contralesional saccades in hemispatial neglect.

    abstract::Patients with unilateral neglect are impaired at making saccades to contralesional targets. Whether this problem arises from a deficit in perception, in planning the saccade or in executing the eye movement or some combination thereof remains unclear. We measured several variables related to the initiation and executi...

    journal_title:Behavioural neurology

    pub_type: 临床试验,杂志文章

    doi:10.1155/2002/253201

    authors: Behrmann M,Ghiselli-Crippa T,Dimatteo I

    更新日期:2001-01-01 00:00:00

  • Neuropsychological rehabilitation in mild and moderate Alzheimer's disease patients.

    abstract:OBJECTIVE:The purpose of this study was to analyze the effect of a neuropsychological rehabilitation (NR) program on patients with Alzheimer's disease (AD). METHODS:The sample was composed of 16 elderly outpatients who participated in an open trial with rivastigmine (6 to 12 mg/day) for 4 months and were randomized to...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2007/915816

    authors: Avila R,Carvalho IA,Bottino CM,Miotto EC

    更新日期:2007-01-01 00:00:00

  • Lack of noradrenergic modulation of indirect semantic priming.

    abstract::Norepinephrine and dopamine are both believed to affect signal-to-noise in the cerebral cortex. Dopaminergic agents appear to modulate semantic networks during indirect semantic priming, but do not appear to affect problem solving dependent on access to semantic networks. Noradrenergic agents, though, do affect semant...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-2009-0236

    authors: Cios JS,Miller RF,Hillier A,Tivarus ME,Beversdorf DQ

    更新日期:2009-01-01 00:00:00

  • Robotics in Lower-Limb Rehabilitation after Stroke.

    abstract::With the increase in the elderly, stroke has become a common disease, often leading to motor dysfunction and even permanent disability. Lower-limb rehabilitation robots can help patients to carry out reasonable and effective training to improve the motor function of paralyzed extremity. In this paper, the developments...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.1155/2017/3731802

    authors: Zhang X,Yue Z,Wang J

    更新日期:2017-01-01 00:00:00

  • Neurological soft signs in obsessive compulsive disorder: standardised assessment and comparison with schizophrenia.

    abstract::While several studies have detected raised levels of neurological soft signs in patients with obsessive compulsive disorder (OCD), the specificity of these abnormalities remains uncertain. This study used a new standardised measure, the Cambridge Neurological Inventory (CNI), to assess soft signs in 51 subjects with O...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/1999/639045

    authors: Bolton D,Gibb W,Lees A,Raven P,Gray JA,Chen E,Shafran R

    更新日期:1998-01-01 00:00:00

  • Syndrome-specific deficits of performance and effects of practice on arm movements with deafferentation due to posterior thalamic lesion.

    abstract::Aiming and tapping movements were analysed repeatedly over a three-week period in a patient who was hemideafferented due to an ischaemic posterior thalamic lesion. Contrasting behaviour observed in six healthy subjects, nine hemiparetic patients and one patient with hemianopic stroke, allowed the determination of beha...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1997-10103

    authors: Platz T,Mauritz KH

    更新日期:1997-01-01 00:00:00

  • Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy Control.

    abstract::Dementia with Lewy bodies (DLB) is the second most common degenerative dementia of the central nervous system. The technique 18F-fluorodeoxyglucose positron emission tomography (18F FDG PET) was used to investigate brain metabolism patterns in DLB patients. Conventional statistical methods did not consider intern meta...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2018/8420658

    authors: Chen D,Lu J,Zhou H,Jiang J,Wu P,Guo Q,Ge J,Zhang H,Shi K,Zuo C

    更新日期:2018-05-08 00:00:00

  • Lack of selective vulnerability to anticholinergic induced cognitive impairment in early Parkinson's disease.

    abstract::Thirteen patients with idiopathic Parkinson's disease of recent onset (mean age 63·2 years) and a group of 10 young healthy volunteers (mean age 26·1 years) underwent a series of neuropsychological tests for assessment of memory, learning ability and mental processing speed before and during treatment with trihexyphen...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1991-4206

    authors: Schelosky L,Benke T,Poewe W

    更新日期:1991-01-01 00:00:00

  • Treatment of Tourette syndrome with cannabinoids.

    abstract::Cannabinoids have been used for hundred of years for medical purposes. To day, the cannabinoid delta-9-tetrahydrocannabinol (THC) and the cannabis extract nabiximols are approved for the treatment of nausea, anorexia and spasticity, respectively. In Tourette syndrome (TS) several anecdotal reports provided evidence th...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.3233/BEN-120276

    authors: Müller-Vahl KR

    更新日期:2013-01-01 00:00:00

  • Ideomotor Apraxia in Left Thalamic Hemorrhage: Discrepancy between Clinical Course and SPECT.

    abstract::We present a patient who developed severe ideomotor apraxia (IA) and subcortical aphasia after a hemorrhage involving the posterior part of the left thalamus and the posterior limb of the internal capsule. The cerebral blood flow (CBF) of the left hemisphere as measured by 99Tc-HM-PAO SPECT was initially diminished as...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1991-4102

    authors: Schnider A,Landis T,Rösler HR

    更新日期:1991-01-01 00:00:00

  • Whakawhiti Kōrero, a Method for the Development of a Cultural Assessment Tool, Te Waka Kuaka, in Māori Traumatic Brain Injury.

    abstract::The importance of tools for the measurement of outcomes and needs in traumatic brain injury is well recognised. The development of tools for these injuries in indigenous communities has been limited despite the well-documented disparity of brain injury. The wairua theory of traumatic brain injury (TBI) in Māori propos...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2015/137402

    authors: Elder H,Kersten P

    更新日期:2015-01-01 00:00:00

  • Emotional processing following cortical and subcortical brain damage: contribution of the fronto-striatal circuitry.

    abstract::The present study examined the differential contribution of cortical and subcortical brain structures in emotional processing by comparing patients with focal cortical lesions (n = 32) to those with primarily subcortical dysregulation of the basal ganglia (Parkinson's disease n = 14). A standardized measure of emotion...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/1998/579029

    authors: Breitenstein C,Daum I,Ackermann H

    更新日期:1998-01-01 00:00:00

  • Dissociative disturbance in Hangul-Hanja reading after a left posterior occipital lesion.

    abstract::Since the Korean language has two distinct writing systems, phonogram (Hangul) and ideogram (Hanja: Chinese characters), alexia can present with dissociative disturbances in reading between the two systems. A 74-year-old right-handed man presented with a prominent reading impairment in Hangul with agraphia of both Han...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-2008-0211

    authors: Park KC,Yoon SS

    更新日期:2008-01-01 00:00:00

  • Visual hypo and hypergnosia as exemplars of poles of psychic tonus in the occipital lobes: multiple case analyses.

    abstract::The "psychic tonus" model or PTM [1] of hemispheric specialization states that the left hemisphere is a psychic and behavioral activator and that the right hemisphere is an inhibitor. The PTM predicts that the tonus of visual representation ought to manifest hemispheric specialization in the occipital lobes. Specifica...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.1155/2008/139436

    authors: Braun CM,Guimond A

    更新日期:2008-01-01 00:00:00

  • Neural measures of conscious and unconscious memory.

    abstract::Neuropsychological studies of memory disorders have played a prominent role in the development of theories of memory. To test and refine such theories in future, it will be advantageous to include research that utilizes physiological measures of the neural events responsible for memory. Measures of the electrical acti...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2000/865250

    authors: Paller KA

    更新日期:2000-01-01 00:00:00

  • Dementia of frontal lobe type and amyotrophy.

    abstract::Dementia of frontal lobe type may precede motor signs in a number of adult patients with amyotrophy. Neuropathological studies have shown neuron loss, spongiosis and gliosis mainly in layers II and III of the frontal and temporal lobes, together with myelin pallor of the subcortical white matter. Golgi studies reveale...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1992-5204

    authors: Ferrer I

    更新日期:1992-01-01 00:00:00

  • Psychogenic and organic amnesia: a multidimensional assessment of clinical, neuroradiological, neuropsychological and psychopathological features.

    abstract::Psychogenic amnesia is a complex disorder characterised by a wide variety of symptoms. Consequently, in a number of cases it is difficult distinguish it from organic memory impairment. The present study reports a new case of global psychogenic amnesia compared with two patients with amnesia underlain by organic brain ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2007/193140

    authors: Serra L,Fadda L,Buccione I,Caltagirone C,Carlesimo GA

    更新日期:2007-01-01 00:00:00

  • Sevoflurane Impairs Short-Term Memory by Affecting PSD-95 and AMPA Receptor in the Hippocampus of a Mouse Model.

    abstract:Objective:To explore the effects of sevoflurane on the latency and error times of the passive avoidance and levels of PSD-95 and AMPA receptors in the hippocampus. We evaluated the effects of sevoflurane on short-term memory in adult mice and explored the possible mechanism. Methods:144 Kunming mice (2-3 months, 30-35...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2019/1068260

    authors: Jiao Y,Fan H,Wang K,Lu S

    更新日期:2019-10-21 00:00:00

  • Association between Neuron-Specific Enolase Gene Polymorphism and Delayed Encephalopathy after Acute Carbon Monoxide Poisoning.

    abstract:Objective:The aim of this study is to explore the relationship between neuron-specific enolase (NSE) gene polymorphism and delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) and provide a theoretical basis for DEACMP pathogenesis, diagnosis, and prognosis. Methods:To investigate this relationship, w...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2020/8819210

    authors: Xu L,Liu X,Zhao J,Zeng J,Gu J,Zhang X,Zhang F,Han Y,Li W,Zhang P,Gu R

    更新日期:2020-10-14 00:00:00