Abstract:
:Subjects with Alzheimer's disease (AD) show loss of cognitive functions and change in behavioral and functional state affecting the quality of their daily life and that of their families and caregivers. A neuropsychological assessment plays a crucial role in detecting such changes from normal conditions. However, despite the existence of clinical measures that are used to classify and diagnose AD, a large amount of subjectivity continues to exist. Our aim was to assess the potential of machine learning in quantifying this process and optimizing or even reducing the amount of neuropsychological tests used to classify AD patients, also at an early stage of impairment. We investigated the role of twelve state-of-the-art neuropsychological tests in the automatic classification of subjects with none, mild, or severe impairment as measured by the clinical dementia rating (CDR). Data were obtained from the ADNI database. In the groups of measures used as features, we included measures of both cognitive domains and subdomains. Our findings show that some tests are more frequently best predictors for the automatic classification, namely, LM, ADAS-Cog, AVLT, and FAQ, with a major role of the ADAS-Cog measures of delayed and immediate memory and the FAQ measure of financial competency.
journal_name
Behav Neuroljournal_title
Behavioural neurologyauthors
Battista P,Salvatore C,Castiglioni Idoi
10.1155/2017/1850909subject
Has Abstractpub_date
2017-01-01 00:00:00pages
1850909eissn
0953-4180issn
1875-8584journal_volume
2017pub_type
杂志文章abstract::The serum concentration achieved and maintained following the administration of a fixed drug dosage is a direct consequence of the interactions of a wide variety of interrelated processes, including drug absorption, distribution, metabolism, and excretion, and the physiological status of the patient. These interrelati...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1990-31S102
更新日期:1990-01-01 00:00:00
abstract:Aim:To identify the factors protecting Abeta-positive subjects with normal cognition (NC) or mild cognitive impairment (MCI) from conversion to Alzheimer's disease (AD). Methods:Subjects with MCI in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, with baseline data for neuropsychological tests, brain ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/7029642
更新日期:2020-10-29 00:00:00
abstract::Aberrant production of nitric oxide following inducible nitric oxide synthase (iNOS) expression has been implicated in cell death and contributes to ischemic brain injury. Tetrahydrobiopterin (BH4) is an essential cofactor of NOS activity. Herein, we evaluated antiapoptotic and anti-inflammatory effects of diamino-6-h...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/5050469
更新日期:2018-06-19 00:00:00
abstract::A large amount of research has been conducted on the effects of sex hormones on gender differences in patients with depression, yet research on cognitive differences between male and female patients with depression is insufficient. This study uses emotion pictures to investigate the differences of the emotional workin...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/807343
更新日期:2015-01-01 00:00:00
abstract::This report presents a syndrome resembling obsessive convulsive disorder (OCD) secondary to a stroke in the left basal ganglia. The patient's syndrome is virtually identical to those that have been described in bilateral damage of the basal ganglia. However, the stroke described in this case report is located unilater...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1997-102-308
更新日期:1997-01-01 00:00:00
abstract:Background:Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) share many risk factors. Evidence suggests that metabolic risk factors are important to AD; however, their association with DLB is unclear. The risk of cardiovascular diseases (CVD) associated with AD and DLB is also uncertain. Thus, this nationwid...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/8312346
更新日期:2018-06-03 00:00:00
abstract::The jugular venous pulse (JVP) provides valuable information about cardiac haemodynamics and filling pressures and is an indirect estimate of the central venous pressure (CVP). Recently it has been proven that JVP can be obtained by measuring the cross-sectional area (CSA) of the IJV on each sonogram of an ultrasound ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/170756
更新日期:2015-01-01 00:00:00
abstract::Patients with Cushing's syndrome (CS) frequently report impairments in cognitive and emotional functioning. Given neuroimaging research that implicates alterations in structure and function in the brain in this population, goals of this study were to investigate neuropsychological and emotional functioning, with parti...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/4064370
更新日期:2020-08-07 00:00:00
abstract::Norepinephrine and dopamine are both believed to affect signal-to-noise in the cerebral cortex. Dopaminergic agents appear to modulate semantic networks during indirect semantic priming, but do not appear to affect problem solving dependent on access to semantic networks. Noradrenergic agents, though, do affect semant...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2009-0236
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Patients with clinically isolated syndrome (CIS) demonstrate brain hemodynamic changes and also suffer from difficulties in processing speed, memory, and executive functions. OBJECTIVE:To explore whether brain hemodynamic disturbances in CIS patients correlate with executive functions. METHODS:Thirty CIS p...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/252419
更新日期:2014-01-01 00:00:00
abstract::Sex-related asymmetries in the ability to process different semantic categories have been reported both in normal subjects and in brain-damaged patients, but the nature of these asymmetries is still controversial. Some authors suggest that these differences might be due to social-role related familiarity factors, wher...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/ben-2009-0247
更新日期:2010-01-01 00:00:00
abstract::Our purpose in undertaking the present study was to examine the hypotheses proposed for explaining the frequent comorbidity of bipolar disorder and multiple sclerosis. One hypothesis posits that, when there is comorbidity, MS plays a causal role in psychiatric manifestations. Another suggests that both disorders have ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2012-110198
更新日期:2012-01-01 00:00:00
abstract::A case of late onset sporadic startle syndrome in a patient with a right posterior fossa brain tumour is reported. The exaggerated startle response did not respond to treatment with clonazepam. In addition to anxiety and depression, the patient developed obsessive- compulsive symptoms which responded to behavioural th...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/1998/617160
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Tacrolimus-associated encephalopathy (TAC-E) is usually described under the term of posterior reversible encephalopathy syndrome (PRES). However, a large amount of data has suggested that TAC-E is not a homogenous entity: indeed, TAC-E which is often presented with atypical and potentially misleading imaging...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/931808
更新日期:2014-01-01 00:00:00
abstract:Objective:The aim of this study is to explore the relationship between neuron-specific enolase (NSE) gene polymorphism and delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) and provide a theoretical basis for DEACMP pathogenesis, diagnosis, and prognosis. Methods:To investigate this relationship, w...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/8819210
更新日期:2020-10-14 00:00:00
abstract::With the increase in the elderly, stroke has become a common disease, often leading to motor dysfunction and even permanent disability. Lower-limb rehabilitation robots can help patients to carry out reasonable and effective training to improve the motor function of paralyzed extremity. In this paper, the developments...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2017/3731802
更新日期:2017-01-01 00:00:00
abstract::Juxtaposed alongside the ongoing rise in the incidence and prevalence of dementia, is the surge of recent research confirming widespread exposure and bioaccumulation of chemical toxicants. Evidence from sources such as the Centers for Disease Control reveals that most people have accrued varying degrees of assorted to...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/620143
更新日期:2015-01-01 00:00:00
abstract::Neglect behavior of experimental animals with unilateral posterior cortical lesions improves with the placement of a second lesion in the contralesional superior colliculus or in the intercollicular commissure. Given that the retinotectal fibers are mainly crossed, it has been speculated that ipsilesional eye patching...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1994-73-408
更新日期:1994-01-01 00:00:00
abstract::Current research supports the strong potential of structural MRI profiles, even within cross-sectional designs, as a promising method for the discrimination of Alzheimer's Disease (AD) from normal controls and for the prediction of Mild Cognitive Impairment (MCI) progression and conversion to AD. Findings suggest that...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-2009-0230
更新日期:2009-01-01 00:00:00
abstract::The importance of tools for the measurement of outcomes and needs in traumatic brain injury is well recognised. The development of tools for these injuries in indigenous communities has been limited despite the well-documented disparity of brain injury. The wairua theory of traumatic brain injury (TBI) in Māori propos...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/137402
更新日期:2015-01-01 00:00:00
abstract::When assessing for the presence of hemianesthesia, the examiner touches the body of the patients, and requests that they report verbally the location of the delivered tactile stimulus. Contralesional omissions of single tactile stimuli, however, might be due to either primary somatosensory deficits or to spatial atten...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2012-110225
更新日期:2013-01-01 00:00:00
abstract::Since the very beginning of the aphasia history it has been well established that there are two major aphasic syndromes (Wernicke's-type and Broca's-type aphasia); each one of them is related to the disturbance at a specific linguistic level (lexical/semantic and grammatical) and associated with a particular brain dam...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2015/872487
更新日期:2015-01-01 00:00:00
abstract::The present study examined the differential contribution of cortical and subcortical brain structures in emotional processing by comparing patients with focal cortical lesions (n = 32) to those with primarily subcortical dysregulation of the basal ganglia (Parkinson's disease n = 14). A standardized measure of emotion...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/1998/579029
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Impaired cardiac function can adversely affect the brain via decreased perfusion. The purpose of this study was to determine if cardiac ejection fraction (EF) is associated with cognitive performance, and whether this is modified by low blood pressure. METHODS:Neuropsychological testing evaluati...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2009-0261
更新日期:2010-01-01 00:00:00
abstract::Primary sexual dysfunctions (SD) are a direct result of neurological changes that affect the sexual response. Secondary SD result from the symptoms that do not directly involve nervous pathways to the genital system, such as bladder and bowel problems, fatigue, spasticity, or muscle weakness. Tertiary SD are the resul...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/8857516
更新日期:2020-10-10 00:00:00
abstract::Patients with brain function disorders due to stroke or dementia may show inability to recognize themselves in the mirror. Although the cognitive ability to recognize mirror images has been investigated in many animal species, the animal species that can be used for experimentation and the mechanisms involved in recog...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/4071315
更新日期:2020-02-03 00:00:00
abstract::The clinical and neuroradiological findings of three patients with marked palilalia due to different neurological disorders are reported. These cases and others in the literature suggest the possibility of different variations. "Spasmodic, heterophonic palilalia" is typically observed in Parkinson's syndrome and pseud...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1992-5407
更新日期:1992-01-01 00:00:00
abstract::Tardive dystonia was identified in 25 patients: involvement of the face and neck was most common; truncal and limb dystonia were also observed. There were 3 cases of laryngospasm and 2 of spasmodic dysphonia. The latter has not been previously reported as a manifestation of tardive dystonia. In all cases, movements ty...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1988-1106
更新日期:1988-01-01 00:00:00
abstract::We describe a cross-sectional study of aggressive behaviour in a sample of patients suffering from Huntington's disease in a residential nursing home. Data were obtained using the RAGE, a behaviourally oriented rating scale for measuring aggressive behaviour in cognitively impaired patients. Nursing staff rated 27 pat...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1993-6107
更新日期:1993-01-01 00:00:00
abstract::What distinguishes the recall of real-life experiences from that of self-created, fictitious emotionally laden information? Both kinds of information belong to the episodic memory system. Autobiographic memories constitute that part of the episodic memory system that is composed of significant life episodes, primarily...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2000/303651
更新日期:2000-01-01 00:00:00