Abstract:
:Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography (PET) with (11)carbon-labelled Pittsburgh Compound-B ((11)C-PIB), the most extensively studied and best validated tracer. PIB binds specifically to fibrillar beta-amyloid (Abeta) deposits, and is a sensitive marker for Abeta pathology in cognitively normal older individuals and patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). PIB-PET provides us with a powerful tool to examine in vivo the relationship between amyloid deposition, clinical symptoms, and structural and functional brain changes in the continuum between normal aging and AD. Amyloid imaging studies support a model in which amyloid deposition is an early event on the path to dementia, beginning insidiously in cognitively normal individuals, and accompanied by subtle cognitive decline and functional and structural brain changes suggestive of incipient AD. As patients progress to dementia, clinical decline and neurodegeneration accelerate and proceed independently of amyloid accumulation. In the future, amyloid imaging is likely to supplement clinical evaluation in selecting patients for anti-amyloid therapies, while MRI and FDG-PET may be more appropriate markers of clinical progression.
journal_name
Behav Neuroljournal_title
Behavioural neurologyauthors
Rabinovici GD,Jagust WJdoi
10.3233/BEN-2009-0232subject
Has Abstractpub_date
2009-01-01 00:00:00pages
117-28issue
1eissn
0953-4180issn
1875-8584pii
23338Q121V142311journal_volume
21pub_type
杂志文章,评审abstract::Despite a vast literature examining semantic impairment in Alzheimer's disease (AD), consensus regarding the nature of the deficit remains elusive. We re-considered this issue in the context of a framework that assumes semantic cognition can break down in two ways: (1) core semantic representations can degrade or (2) ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2012-0346
更新日期:2012-01-01 00:00:00
abstract::Neglect behavior of experimental animals with unilateral posterior cortical lesions improves with the placement of a second lesion in the contralesional superior colliculus or in the intercollicular commissure. Given that the retinotectal fibers are mainly crossed, it has been speculated that ipsilesional eye patching...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1994-73-408
更新日期:1994-01-01 00:00:00
abstract::The paper examines the ability of Statistical Parametric Mapping (SPM) to contribute towards the quantitative analysis of HMPAO SPECT images containing lesions. A validation study is described in which SPECT images were created that contained synthetic lesions and were analysed with SPM. The study established a set of...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2000/681916
更新日期:2000-01-01 00:00:00
abstract::The global workspace (GW) theory proposes that conscious processing results from coherent neuronal activity between widely distributed brain regions, with fronto-parietal associative cortices as key elements. In this model, transition between conscious and non conscious states are predicted to be caused by abrupt non-...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-2011-0313
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To study risk factors related to ischemic stroke (IS) in youth and the influence of sleep quality on youth ischemic stroke incidence. METHODS:223 patients aged 18 to 45 years who were admitted to Puyang People's Hospital from June 2011 to February 2013 with a first-ever ischemic stroke were selected as the r...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/246841
更新日期:2014-01-01 00:00:00
abstract::We investigated the evolution of the neurological and neuropsychological characteristics in a right-handed woman who was 53-years-old at the onset and who showed personality changes and behavioral disorders accompanied by progressive dysarthria. She had hypernasality and a slow rate of speech with distorted consonants...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2006/320638
更新日期:2006-01-01 00:00:00
abstract::The importance of tools for the measurement of outcomes and needs in traumatic brain injury is well recognised. The development of tools for these injuries in indigenous communities has been limited despite the well-documented disparity of brain injury. The wairua theory of traumatic brain injury (TBI) in Māori propos...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/137402
更新日期:2015-01-01 00:00:00
abstract::We describe a cross-sectional study of aggressive behaviour in a sample of patients suffering from Huntington's disease in a residential nursing home. Data were obtained using the RAGE, a behaviourally oriented rating scale for measuring aggressive behaviour in cognitively impaired patients. Nursing staff rated 27 pat...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1993-6107
更新日期:1993-01-01 00:00:00
abstract::The aim of the present paper was to investigate the fundamental ethical issues of Deep Brain Stimulation (DBS) on patients remaining in Persistent Vegetative State (PVS). First, the purpose of this analysis was to discuss the nature of this intervention in order to classify it such as an ordinary clinical practice, or...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2014/641213
更新日期:2014-01-01 00:00:00
abstract::The neuroanatomical region that has most prominently altered with the advancing cognitive competency of the human is the prefrontal cortex, particularly the rostral extreme. While the prefrontal cortex does not appear to contain the neural networks that carry out cognitive activities, the management of these high leve...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1993-6202
更新日期:1993-01-01 00:00:00
abstract::In addition to motor symptomatology, idiopathic Parkinson's disease is characterized by emotional dysfunction. Depression affects some 30 to 40 percent of Parkinson patients and other psychiatric co-morbidities include anxiety and apathy. Neuropsychological and neuroimaging studies of emotional dysfunction in Parkinso...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-2011-0329
更新日期:2011-01-01 00:00:00
abstract::Traumatic brain injury (TBI) is the most common cause of long-term disability and death among young adults, and it represents an enormous socioeconomic and healthcare burden. Our purpose is to evaluate the effects of a virtual reality training with BTs-Nirvana (BTs-N) on the recovery of cognitive functions in TBI subj...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2019/9268179
更新日期:2019-07-30 00:00:00
abstract::Neurologists and neuropsychologists are aware that aging men are more at risk than women for brain damage, principally because of the well known male-predominant risk for cardiovascular disease and related cerebrovascular accidents. However, a disproportion in prevalence of brain damage between the sexes in childhood ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2002/634764
更新日期:2001-01-01 00:00:00
abstract::The case is reported of a patient (PS) who, following acute encephalitis with residual occipito-temporal damage, showed a selective deficit in writing cursive letters in isolation, but no difficulty to write cursive-case words and non-words. Notably, he was able to recognize the same allographs he could not write and ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2012-119008
更新日期:2012-01-01 00:00:00
abstract::Patients with Cushing's syndrome (CS) frequently report impairments in cognitive and emotional functioning. Given neuroimaging research that implicates alterations in structure and function in the brain in this population, goals of this study were to investigate neuropsychological and emotional functioning, with parti...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/4064370
更新日期:2020-08-07 00:00:00
abstract:Aim:To identify the factors protecting Abeta-positive subjects with normal cognition (NC) or mild cognitive impairment (MCI) from conversion to Alzheimer's disease (AD). Methods:Subjects with MCI in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, with baseline data for neuropsychological tests, brain ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/7029642
更新日期:2020-10-29 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) with dementia (ALS-D) is known to exhibit characteristics of frontotemporal dementia. However, in clinical situations, it is often difficult to evaluate their cognitive functions because of impaired voluntary speech and physical disabilities. In order to identify characteristic and ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2008/814846
更新日期:2008-01-01 00:00:00
abstract::Subjects with Alzheimer's disease (AD) show loss of cognitive functions and change in behavioral and functional state affecting the quality of their daily life and that of their families and caregivers. A neuropsychological assessment plays a crucial role in detecting such changes from normal conditions. However, desp...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2017/1850909
更新日期:2017-01-01 00:00:00
abstract:Objective:The aim of this study is to explore the relationship between neuron-specific enolase (NSE) gene polymorphism and delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) and provide a theoretical basis for DEACMP pathogenesis, diagnosis, and prognosis. Methods:To investigate this relationship, w...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/8819210
更新日期:2020-10-14 00:00:00
abstract:Background:Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) share many risk factors. Evidence suggests that metabolic risk factors are important to AD; however, their association with DLB is unclear. The risk of cardiovascular diseases (CVD) associated with AD and DLB is also uncertain. Thus, this nationwid...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/8312346
更新日期:2018-06-03 00:00:00
abstract::Sex-related asymmetries in the ability to process different semantic categories have been reported both in normal subjects and in brain-damaged patients, but the nature of these asymmetries is still controversial. Some authors suggest that these differences might be due to social-role related familiarity factors, wher...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/ben-2009-0247
更新日期:2010-01-01 00:00:00
abstract::Communication in humans activates almost every part of the brain. Of course, the use of language predominates, but other cognitive functions such as attention, memory, emotion, and executive processes are also involved. However, in order to explain how our brain "understands," "speaks," and "writes," and in order to r...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2019/9894571
更新日期:2019-07-22 00:00:00
abstract::We describe a right-handed patient who suffered a ruptured aneurysm of the anterior communicating artery (ACoA) which was clipped successfully. Computerized tomography indicated a low density area in the genu of the corpus callosum and the infero-lateral aspect of the left frontal lobe. On recovery the patient's most ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1991-4305
更新日期:1991-01-01 00:00:00
abstract::We investigated social cognition and theory of mind in patients with schizophrenia and in patients with frontotemporal dementia in order to elucidate the cognitive mechanisms involved in the breakdown of these skills in psychiatric and neurological patients. Our tasks included videotaped scenarios of social interactio...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2008/157356
更新日期:2008-01-01 00:00:00
abstract::Understanding the mental states of others entails a number of cognitive processes known as Theory of Mind (ToM). A relationship between ToM deficits and executive disorders has been hypothesized in individuals with Parkinson's disease (PD). The present study was aimed at investigating the effect of dysexecutive defici...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-129018
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Patients with clinically isolated syndrome (CIS) demonstrate brain hemodynamic changes and also suffer from difficulties in processing speed, memory, and executive functions. OBJECTIVE:To explore whether brain hemodynamic disturbances in CIS patients correlate with executive functions. METHODS:Thirty CIS p...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/252419
更新日期:2014-01-01 00:00:00
abstract::This study examined hemispatial bias in a free-viewing condition of the judgement of facial expressions of emotions. Right-handed male subjects were asked to judge the intensity, in terms of expressiveness, of facial emotion in normal and mirror-reversed orientations. Expressions in mirror-reversed orientation were pe...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1996-93-402
更新日期:1996-01-01 00:00:00
abstract:Objective:To explore the effects of sevoflurane on the latency and error times of the passive avoidance and levels of PSD-95 and AMPA receptors in the hippocampus. We evaluated the effects of sevoflurane on short-term memory in adult mice and explored the possible mechanism. Methods:144 Kunming mice (2-3 months, 30-35...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2019/1068260
更新日期:2019-10-21 00:00:00
abstract::Neuropsychological studies of memory disorders have played a prominent role in the development of theories of memory. To test and refine such theories in future, it will be advantageous to include research that utilizes physiological measures of the neural events responsible for memory. Measures of the electrical acti...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2000/865250
更新日期:2000-01-01 00:00:00
abstract::Cognitive impairment in multiple sclerosis is an increasingly recognized entity. This article reviews the cognitive impairment of multiple sclerosis, its prevalence, its relationship to different types of multiple sclerosis, and its contribution to long-term functional prognosis. The discussion also focuses on the key...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2006/545860
更新日期:2006-01-01 00:00:00