Treatment of cognitive impairment in multiple sclerosis.


:Cognitive impairment in multiple sclerosis is an increasingly recognized entity. This article reviews the cognitive impairment of multiple sclerosis, its prevalence, its relationship to different types of multiple sclerosis, and its contribution to long-term functional prognosis. The discussion also focuses on the key elements of cognitive dysfunction in multiple sclerosis which distinguish it from other forms of cognitive impairment. Therapeutic interventions potentially effective for the cognitive impairment of multiple sclerosis are reviewed including the effects of disease modifying therapies and the use of physical and cognitive interventions.


Behav Neurol


Behavioural neurology


Pierson SH,Griffith N




Has Abstract


2006-01-01 00:00:00












  • Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy Control.

    abstract::Dementia with Lewy bodies (DLB) is the second most common degenerative dementia of the central nervous system. The technique 18F-fluorodeoxyglucose positron emission tomography (18F FDG PET) was used to investigate brain metabolism patterns in DLB patients. Conventional statistical methods did not consider intern meta...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Chen D,Lu J,Zhou H,Jiang J,Wu P,Guo Q,Ge J,Zhang H,Shi K,Zuo C

    更新日期:2018-05-08 00:00:00

  • Association between hypotension, low ejection fraction and cognitive performance in cardiac patients.

    abstract:BACKGROUND AND PURPOSE:Impaired cardiac function can adversely affect the brain via decreased perfusion. The purpose of this study was to determine if cardiac ejection fraction (EF) is associated with cognitive performance, and whether this is modified by low blood pressure. METHODS:Neuropsychological testing evaluati...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Gottesman RF,Grega MA,Bailey MM,Zeger SL,Baumgartner WA,McKhann GM,Selnes OA

    更新日期:2010-01-01 00:00:00

  • Impaired initiation but not execution of contralesional saccades in hemispatial neglect.

    abstract::Patients with unilateral neglect are impaired at making saccades to contralesional targets. Whether this problem arises from a deficit in perception, in planning the saccade or in executing the eye movement or some combination thereof remains unclear. We measured several variables related to the initiation and executi...

    journal_title:Behavioural neurology

    pub_type: 临床试验,杂志文章


    authors: Behrmann M,Ghiselli-Crippa T,Dimatteo I

    更新日期:2001-01-01 00:00:00

  • Mental Fatigue and Executive Dysfunction in Patients with Cushing's Syndrome in Remission.

    abstract::Patients with Cushing's syndrome (CS) in remission often suffer from impaired quality of life and cognitive dysfunction. The primary aim was to investigate the occurrence of mental fatigue, characterized by mental exhaustion and long recovery time following mentally strenuous tasks, in patients with CS in remission. T...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Papakokkinou E,Johansson B,Berglund P,Ragnarsson O

    更新日期:2015-01-01 00:00:00

  • The neurology of proverbs.

    abstract::Although proverb tests are commonly used in the mental status examination surprisingly little is known about either normal comprehension or the interpretation of proverbial expressions. Current proverbs tests have conceptual and linguistic shortcomings, and few studies have been done to investigate the specific effect...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Van Lancker D

    更新日期:1990-01-01 00:00:00

  • Neural measures of conscious and unconscious memory.

    abstract::Neuropsychological studies of memory disorders have played a prominent role in the development of theories of memory. To test and refine such theories in future, it will be advantageous to include research that utilizes physiological measures of the neural events responsible for memory. Measures of the electrical acti...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Paller KA

    更新日期:2000-01-01 00:00:00

  • Completion phenomenon in transcortical sensory aphasia.

    abstract::We investigated completion phenomenon for proverbs in cases demonstrating transcortical sensory aphasia due to a variety of diseases. Lack of this completion was exclusively observed in patients with focal atrophy. These patients showed a selective and consistent impairment in word comprehension without phonemic cue e...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Nakagawa Y,Tanabe H,Ikeda M,Kazui H,Ito K,Inoue N,Hatakenaka Y,Sawada T,Ikeda H,Shiraishi J

    更新日期:1993-01-01 00:00:00

  • Allographic agraphia for single letters.

    abstract::The case is reported of a patient (PS) who, following acute encephalitis with residual occipito-temporal damage, showed a selective deficit in writing cursive letters in isolation, but no difficulty to write cursive-case words and non-words. Notably, he was able to recognize the same allographs he could not write and ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Menichelli A,Machetta F,Zadini A,Semenza C

    更新日期:2012-01-01 00:00:00

  • The global workspace (GW) theory of consciousness and epilepsy.

    abstract::The global workspace (GW) theory proposes that conscious processing results from coherent neuronal activity between widely distributed brain regions, with fronto-parietal associative cortices as key elements. In this model, transition between conscious and non conscious states are predicted to be caused by abrupt non-...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审


    authors: Bartolomei F,Naccache L

    更新日期:2011-01-01 00:00:00

  • How to differentiate hemianesthesia from left tactile neglect: a preliminary case report.

    abstract::When assessing for the presence of hemianesthesia, the examiner touches the body of the patients, and requests that they report verbally the location of the delivered tactile stimulus. Contralesional omissions of single tactile stimuli, however, might be due to either primary somatosensory deficits or to spatial atten...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Pitteri M,Venneri A,Meneghello F,Priftis K

    更新日期:2013-01-01 00:00:00

  • Bipolar disorder and multiple sclerosis: a case series.

    abstract:BACKGROUND:The prevalence of psychiatric disturbance for patients with multiple sclerosis (MS) is higher than that observed in other chronic health conditions. We report three cases of MS and bipolar disorder and we discuss the possible etiological hypothesis and treatment options. OBSERVATIONS:All patients fulfilled ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Sidhom Y,Ben Djebara M,Hizem Y,Abdelkefi I,Kacem I,Gargouri A,Gouider R

    更新日期:2014-01-01 00:00:00

  • Neuroprotective Effect of DAHP via Antiapoptosis in Cerebral Ischemia.

    abstract::Aberrant production of nitric oxide following inducible nitric oxide synthase (iNOS) expression has been implicated in cell death and contributes to ischemic brain injury. Tetrahydrobiopterin (BH4) is an essential cofactor of NOS activity. Herein, we evaluated antiapoptotic and anti-inflammatory effects of diamino-6-h...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Qin Y,Hu W,Yang Y,Hu Z,Li W,Fang M

    更新日期:2018-06-19 00:00:00

  • Behavioural Changes in Mice after Getting Accustomed to the Mirror.

    abstract::Patients with brain function disorders due to stroke or dementia may show inability to recognize themselves in the mirror. Although the cognitive ability to recognize mirror images has been investigated in many animal species, the animal species that can be used for experimentation and the mechanisms involved in recog...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Ueno H,Suemitsu S,Murakami S,Kitamura N,Wani K,Takahashi Y,Matsumoto Y,Okamoto M,Ishihara T

    更新日期:2020-02-03 00:00:00

  • Neuropsychological and Emotional Functioning in Patients with Cushing's Syndrome.

    abstract::Patients with Cushing's syndrome (CS) frequently report impairments in cognitive and emotional functioning. Given neuroimaging research that implicates alterations in structure and function in the brain in this population, goals of this study were to investigate neuropsychological and emotional functioning, with parti...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Na S,Fernandes MA,Ioachimescu AG,Penna S

    更新日期:2020-08-07 00:00:00

  • Unpicking the semantic impairment in Alzheimer's disease: qualitative changes with disease severity.

    abstract::Despite a vast literature examining semantic impairment in Alzheimer's disease (AD), consensus regarding the nature of the deficit remains elusive. We re-considered this issue in the context of a framework that assumes semantic cognition can break down in two ways: (1) core semantic representations can degrade or (2) ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Corbett F,Jefferies E,Burns A,Ralph MA

    更新日期:2012-01-01 00:00:00

  • Pathological laughter as a symptom of midbrain infarction.

    abstract::Pathological laughter is an uncommon symptom usually caused by bilateral, diffuse cerebral lesions. It has rarely been reported in association with isolated cerebral lesions. Midbrain involvement causing pathological laughter is extremely unusual. We describe three patients who developed pathological laughter after mi...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Dabby R,Watemberg N,Lampl Y,Eilam A,Rapaport A,Sadeh M

    更新日期:2004-01-01 00:00:00

  • A crossed Kana agraphia.

    abstract::We report a right-handed man who developed selective Kana (phonogram) agraphia following an infarct in the non-dominant right cerebral hemisphere. His ability for comprehension, reading and writing of Kanji (ideogram) was unaffected. Kana errors consisted of substitution with another letter and the number of target wo...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Abe K,Yokoyama R,Yanagihara T

    更新日期:1995-01-01 00:00:00

  • Antiepileptic Drug Nonadherence and Its Predictors among People with Epilepsy.

    abstract::Introduction. Antiepileptic drugs are effective in the treatment of epilepsy to the extent that about 70% of people with epilepsy can be seizure-free, but poor adherence to medication is major problem to sustained remission and functional restoration. The aim of this study was to assess the prevalence and associated f...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Getnet A,Woldeyohannes SM,Bekana L,Mekonen T,Fekadu W,Menberu M,Yimer S,Assaye A,Belete A,Belete H

    更新日期:2016-01-01 00:00:00

  • Emotional dysfunction in Parkinson's disease.

    abstract::In addition to motor symptomatology, idiopathic Parkinson's disease is characterized by emotional dysfunction. Depression affects some 30 to 40 percent of Parkinson patients and other psychiatric co-morbidities include anxiety and apathy. Neuropsychological and neuroimaging studies of emotional dysfunction in Parkinso...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审


    authors: Blonder LX,Slevin JT

    更新日期:2011-01-01 00:00:00

  • Emotional processing following cortical and subcortical brain damage: contribution of the fronto-striatal circuitry.

    abstract::The present study examined the differential contribution of cortical and subcortical brain structures in emotional processing by comparing patients with focal cortical lesions (n = 32) to those with primarily subcortical dysregulation of the basal ganglia (Parkinson's disease n = 14). A standardized measure of emotion...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Breitenstein C,Daum I,Ackermann H

    更新日期:1998-01-01 00:00:00

  • Neural plasticity in functional and anatomical MRI studies of children with Tourette syndrome.

    abstract:BACKGROUND:Tourette syndrome (TS) is a neuropsychiatric disorder with childhood onset characterized by chronic motor and vocal tics. The typical clinical course of an attenuation of symptoms during adolescence in parallel with the emerging self-regulatory control during development suggests that plastic processes may p...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审


    authors: Eichele H,Plessen KJ

    更新日期:2013-01-01 00:00:00

  • Familial comorbidity of bipolar disorder and multiple sclerosis: genetic susceptibility, coexistence or causal relationship?

    abstract::Our purpose in undertaking the present study was to examine the hypotheses proposed for explaining the frequent comorbidity of bipolar disorder and multiple sclerosis. One hypothesis posits that, when there is comorbidity, MS plays a causal role in psychiatric manifestations. Another suggests that both disorders have ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Kosmidis MH,Bozikas VP,Giannouli V,Karavatos A,Fokas K

    更新日期:2012-01-01 00:00:00

  • The Effect of Task-Irrelevant Fearful-Face Distractor on Working Memory Processing in Mild Cognitive Impairment versus Healthy Controls: An Exploratory fMRI Study in Female Participants.

    abstract::In mild cognitive impairment (MCI), a risk state for Alzheimer's disease, patients have objective cognitive deficits with relatively preserved functioning. fMRI studies have identified anomalies during working memory (WM) processing in individuals with MCI. The effect of task-irrelevant emotional face distractor on WM...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Burhan AM,Anazodo UC,Chung JK,Arena A,Graff-Guerrero A,Mitchell DG

    更新日期:2016-01-01 00:00:00

  • Correlation analysis of sleep quality and youth ischemic stroke.

    abstract:OBJECTIVE:To study risk factors related to ischemic stroke (IS) in youth and the influence of sleep quality on youth ischemic stroke incidence. METHODS:223 patients aged 18 to 45 years who were admitted to Puyang People's Hospital from June 2011 to February 2013 with a first-ever ischemic stroke were selected as the r...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Zhang S,Chang C,Zhang J,Song B,Fang H,Xu Y

    更新日期:2014-01-01 00:00:00

  • Optimizing Neuropsychological Assessments for Cognitive, Behavioral, and Functional Impairment Classification: A Machine Learning Study.

    abstract::Subjects with Alzheimer's disease (AD) show loss of cognitive functions and change in behavioral and functional state affecting the quality of their daily life and that of their families and caregivers. A neuropsychological assessment plays a crucial role in detecting such changes from normal conditions. However, desp...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Battista P,Salvatore C,Castiglioni I

    更新日期:2017-01-01 00:00:00

  • Is there a place for ipsilesional eye patching in neglect rehabilitation?

    abstract::Neglect behavior of experimental animals with unilateral posterior cortical lesions improves with the placement of a second lesion in the contralesional superior colliculus or in the intercollicular commissure. Given that the retinotectal fibers are mainly crossed, it has been speculated that ipsilesional eye patching...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Soroker N,Cohen T,Baratz C,Glicksohn J,Myslobodsky MS

    更新日期:1994-01-01 00:00:00

  • Obsessive compulsive disorder in a woman with left basal ganglia infarct: A case report.

    abstract::This report presents a syndrome resembling obsessive convulsive disorder (OCD) secondary to a stroke in the left basal ganglia. The patient's syndrome is virtually identical to those that have been described in bilateral damage of the basal ganglia. However, the stroke described in this case report is located unilater...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Lopez-Rodriguez F,Gunay I,Glaser N

    更新日期:1997-01-01 00:00:00

  • Mirror-reversal of a face is perceived as expressing emotions more intensely.

    abstract::This study examined hemispatial bias in a free-viewing condition of the judgement of facial expressions of emotions. Right-handed male subjects were asked to judge the intensity, in terms of expressiveness, of facial emotion in normal and mirror-reversed orientations. Expressions in mirror-reversed orientation were pe...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Asthana HS,Mandal MK

    更新日期:1996-01-01 00:00:00

  • Tardive dystonia: clinical spectrum and novel manifestations.

    abstract::Tardive dystonia was identified in 25 patients: involvement of the face and neck was most common; truncal and limb dystonia were also observed. There were 3 cases of laryngospasm and 2 of spasmodic dysphonia. The latter has not been previously reported as a manifestation of tardive dystonia. In all cases, movements ty...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Davis RJ,Cummings JL,Hierholzer RW

    更新日期:1988-01-01 00:00:00

  • Identifying the Symptom Severity in Obsessive-Compulsive Disorder for Classification and Prediction: An Artificial Neural Network Approach.

    abstract::The present study is aimed at identifying the most prominent determinants of OCD along with their strength to classify the OCD patients from healthy controls. The data for this cross-sectional study were collected from 200 diagnosed OCD patients and 400 healthy controls. The respondents were selected through purposive...

    journal_title:Behavioural neurology

    pub_type: 杂志文章


    authors: Shahzad MN,Suleman M,Ahmed MA,Riaz A,Fatima K

    更新日期:2020-06-22 00:00:00