Abstract:
:Cognitive impairment is frequently encountered in multiple sclerosis (MS) affecting between 40-65% of individuals, irrespective of disease duration and severity of physical disability. In the present multicenter randomized controlled trial, fifty-eight clinically stable RRMS patients with mild to moderate cognitive impairment and relatively low disability status were randomized to receive either computer-assisted (RehaCom) functional cognitive training with an emphasis on episodic memory, information processing speed/attention, and executive functions for 10 weeks (IG; n = 32) or standard clinical care (CG; n = 26). Outcome measures included a flexible comprehensive neuropsychological battery of tests sensitive to MS patient deficits and feedback regarding personal benefit gained from the intervention on four verbal questions. Only the IG group showed significant improvements in verbal and visuospatial episodic memory, processing speed/attention, and executive functioning from pre - to postassessment. Moreover, the improvement obtained on attention was retained over 6 months providing evidence on the long-term benefits of this intervention. Group by time interactions revealed significant improvements in composite cognitive domain scores in the IG relative to the demographically and clinically matched CG for verbal episodic memory, processing speed, verbal fluency, and attention. Treated patients rated the intervention positively and were more confident about their cognitive abilities following treatment.
journal_name
Behav Neuroljournal_title
Behavioural neurologyauthors
Messinis L,Nasios G,Kosmidis MH,Zampakis P,Malefaki S,Ntoskou K,Nousia A,Bakirtzis C,Grigoriadis N,Gourzis P,Papathanasopoulos Pdoi
10.1155/2017/5919841subject
Has Abstractpub_date
2017-01-01 00:00:00pages
5919841eissn
0953-4180issn
1875-8584journal_volume
2017pub_type
杂志文章,多中心研究,随机对照试验abstract::Dementia with Lewy bodies (DLB) is the second most common degenerative dementia of the central nervous system. The technique 18F-fluorodeoxyglucose positron emission tomography (18F FDG PET) was used to investigate brain metabolism patterns in DLB patients. Conventional statistical methods did not consider intern meta...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/8420658
更新日期:2018-05-08 00:00:00
abstract::Frontotemporal dementia (FTD) affects behavior, language, and personality. This study aims to explore functional connectivity changes in three FTD variants: behavioral (bvFTD), semantic (svPPA), and nonfluent variant (nfvPPA). Seventy-six patients diagnosed with FTD by international criteria and thirty-two controls we...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/9684129
更新日期:2018-04-01 00:00:00
abstract:Objective:To compare baseline and 72-hour hormone levels in women with traumatic brain injury (TBI) and controls. Setting:Hospital emergency department. Participants:21 women ages 18-35 with TBI and 21 controls. Design:Repeated measures. Main Measures:Serum samples at baseline and 72 hours; immunoassays for estradi...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2019/7694503
更新日期:2019-02-12 00:00:00
abstract::When assessing for the presence of hemianesthesia, the examiner touches the body of the patients, and requests that they report verbally the location of the delivered tactile stimulus. Contralesional omissions of single tactile stimuli, however, might be due to either primary somatosensory deficits or to spatial atten...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2012-110225
更新日期:2013-01-01 00:00:00
abstract::The serum concentration achieved and maintained following the administration of a fixed drug dosage is a direct consequence of the interactions of a wide variety of interrelated processes, including drug absorption, distribution, metabolism, and excretion, and the physiological status of the patient. These interrelati...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1990-31S102
更新日期:1990-01-01 00:00:00
abstract::Three points of interest lie in considering how Alzheimer, and more significantly Perusini, struggled to throw light on the cause of this devastating disease. There is a stimulating possibility that Perusini believed presenile forms of Alzheimer's disease described the same disease as senile forms. If so this would an...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1997-10401
更新日期:1997-01-01 00:00:00
abstract::Dementia of frontal lobe type may precede motor signs in a number of adult patients with amyotrophy. Neuropathological studies have shown neuron loss, spongiosis and gliosis mainly in layers II and III of the frontal and temporal lobes, together with myelin pallor of the subcortical white matter. Golgi studies reveale...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1992-5204
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Tourette syndrome (TS) is a neuropsychiatric disorder with childhood onset characterized by chronic motor and vocal tics. The typical clinical course of an attenuation of symptoms during adolescence in parallel with the emerging self-regulatory control during development suggests that plastic processes may p...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-120294
更新日期:2013-01-01 00:00:00
abstract:Objective:To explore the effects of sevoflurane on the latency and error times of the passive avoidance and levels of PSD-95 and AMPA receptors in the hippocampus. We evaluated the effects of sevoflurane on short-term memory in adult mice and explored the possible mechanism. Methods:144 Kunming mice (2-3 months, 30-35...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2019/1068260
更新日期:2019-10-21 00:00:00
abstract::We present a patient who developed severe ideomotor apraxia (IA) and subcortical aphasia after a hemorrhage involving the posterior part of the left thalamus and the posterior limb of the internal capsule. The cerebral blood flow (CBF) of the left hemisphere as measured by 99Tc-HM-PAO SPECT was initially diminished as...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1991-4102
更新日期:1991-01-01 00:00:00
abstract::Two experiments examined short-term memory for order information in six patients diagnosed with Parkinson's disease (PD) and six control subjects while event related potentials (ERPs) were recorded. The subjects were tested for recognition of abstract spatial designs and words after a 5 s retention interval. The PD pa...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1996-9203
更新日期:1996-01-01 00:00:00
abstract:Background:Medication adherence and belief are crucial to achieving the desired goal of therapy in epileptic patients. However, there is a lack of study regarding medication adherence and belief in our setting. Therefore, the purpose of this study was to investigate medication adherence and belief and associated factor...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2019/2806341
更新日期:2019-04-23 00:00:00
abstract::Eighty-five patients with idiopathic spasmodic torticollis were compared with an equally chronic group of 49 cervical spondylosis sufferers in terms of body concept, depression, and disability. The torticollis patients were significantly more depressed and disabled and had a more negative body concept. Depression had ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1990-3206
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The extent of brain damage in chronic stroke patients is traditionally defined as the necrotic tissue observed on magnetic resonance image (MRI). However, patients often exhibit symptoms suggesting that functional impairment may affect areas beyond the cortical necrotic lesion, for example, when cortical sym...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/215380
更新日期:2014-01-01 00:00:00
abstract::While several studies have detected raised levels of neurological soft signs in patients with obsessive compulsive disorder (OCD), the specificity of these abnormalities remains uncertain. This study used a new standardised measure, the Cambridge Neurological Inventory (CNI), to assess soft signs in 51 subjects with O...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/1999/639045
更新日期:1998-01-01 00:00:00
abstract::This report presents a syndrome resembling obsessive convulsive disorder (OCD) secondary to a stroke in the left basal ganglia. The patient's syndrome is virtually identical to those that have been described in bilateral damage of the basal ganglia. However, the stroke described in this case report is located unilater...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1997-102-308
更新日期:1997-01-01 00:00:00
abstract::Cannabinoids have been used for hundred of years for medical purposes. To day, the cannabinoid delta-9-tetrahydrocannabinol (THC) and the cannabis extract nabiximols are approved for the treatment of nausea, anorexia and spasticity, respectively. In Tourette syndrome (TS) several anecdotal reports provided evidence th...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-120276
更新日期:2013-01-01 00:00:00
abstract::Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography (PET) with (11)carbon-labelled Pittsburgh Compound-B ((11)C-PIB), ...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-2009-0232
更新日期:2009-01-01 00:00:00
abstract::Neuroimaging studies and experimental data suggest that symptoms of posttraumatic stress disorder (PTSD) are associated with dysfunctions of neural circuits linking prefrontal cortex and the limbic system that have a role in autobiographic episodic memory. High-frequency repetitive transcranial magnetic stimulation (r...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2006/793256
更新日期:2006-01-01 00:00:00
abstract::A déjà vu experience is a dissociative phenomenon, which can be characterized as a subjectively inappropriate impression of familiarity of the present with an undefined past. This paper reviews empirical studies on déjà vu experiences and summarizes the most salient findings. Overall, the findings appear to be inconsi...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1992-5303
更新日期:1992-01-01 00:00:00
abstract::With the increase in the elderly, stroke has become a common disease, often leading to motor dysfunction and even permanent disability. Lower-limb rehabilitation robots can help patients to carry out reasonable and effective training to improve the motor function of paralyzed extremity. In this paper, the developments...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2017/3731802
更新日期:2017-01-01 00:00:00
abstract::What distinguishes the recall of real-life experiences from that of self-created, fictitious emotionally laden information? Both kinds of information belong to the episodic memory system. Autobiographic memories constitute that part of the episodic memory system that is composed of significant life episodes, primarily...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2000/303651
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to analyze the effect of a neuropsychological rehabilitation (NR) program on patients with Alzheimer's disease (AD). METHODS:The sample was composed of 16 elderly outpatients who participated in an open trial with rivastigmine (6 to 12 mg/day) for 4 months and were randomized to...
journal_title:Behavioural neurology
pub_type: 杂志文章,随机对照试验
doi:10.1155/2007/915816
更新日期:2007-01-01 00:00:00
abstract:Objective:The aim of this study is to explore the relationship between neuron-specific enolase (NSE) gene polymorphism and delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) and provide a theoretical basis for DEACMP pathogenesis, diagnosis, and prognosis. Methods:To investigate this relationship, w...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/8819210
更新日期:2020-10-14 00:00:00
abstract::The term functional amnesia (FA) has been proposed for cases of memory impairment presenting with severe retrograde amnesia in the absence of cerebral injury or history of psychiatric disturbance. Emotional flattening has often been reported alongside FA, however the mechanism of such a modification is unknown. This s...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2008/245495
更新日期:2008-01-01 00:00:00
abstract::Thirteen patients with idiopathic Parkinson's disease of recent onset (mean age 63·2 years) and a group of 10 young healthy volunteers (mean age 26·1 years) underwent a series of neuropsychological tests for assessment of memory, learning ability and mental processing speed before and during treatment with trihexyphen...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1991-4206
更新日期:1991-01-01 00:00:00
abstract::Aiming and tapping movements were analysed repeatedly over a three-week period in a patient who was hemideafferented due to an ischaemic posterior thalamic lesion. Contrasting behaviour observed in six healthy subjects, nine hemiparetic patients and one patient with hemianopic stroke, allowed the determination of beha...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1997-10103
更新日期:1997-01-01 00:00:00
abstract::This paper critically examines three strands of evidence that concern the relationship between type A behaviours and coronary heart disease; prospective epidemiological studies of healthy populations, studies of those at high risk for coronary heart disease, and angiographic studies of atherosclerosis. The first of th...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1990-3405
更新日期:1990-01-01 00:00:00
abstract::In addition to motor symptomatology, idiopathic Parkinson's disease is characterized by emotional dysfunction. Depression affects some 30 to 40 percent of Parkinson patients and other psychiatric co-morbidities include anxiety and apathy. Neuropsychological and neuroimaging studies of emotional dysfunction in Parkinso...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-2011-0329
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Gilles de la Tourette Syndrome (GTS) is a childhood-onset hyperkinetic movement disorder defined by the chronic presence of multiple motor tics and at least one vocal tic and often complicated by co-morbid behavioural problems. The pharmacological treatment of GTS focuses on the modulation of monoaminergic...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-2012-120269
更新日期:2013-01-01 00:00:00