Abstract:
:Patients with Cushing's syndrome (CS) frequently report impairments in cognitive and emotional functioning. Given neuroimaging research that implicates alterations in structure and function in the brain in this population, goals of this study were to investigate neuropsychological and emotional functioning, with particular emphasis on complex attention and memory. In a clinical sample of 18 adults with CS referred for neuropsychological evaluation (age 41.6 ± 10.6, 72% Caucasian), patients' most common subjective complaints were in attention and increased irritability. On objective testing, patients exhibited significant declines in the consistency of their sustained attention and visual-spatial functioning compared to normative peers. Patients exhibited on average significantly reduced initial learning following first exposure to visual and verbal stimuli but intact retention of information learned. Patients with CS endorsed highly elevated levels of somatization, depression, and anxiety, and 59% of them scored in the clinically elevated range for somatization and depressive symptomatology. Exploratory analyses suggested that the 11 patients with active Cushing's exhibited lower processing speed, poorer sustained attention, naming, and cognitive flexibility compared to the 7 patients who achieved biochemical remission. Patients with active Cushing's also reported higher levels of somatization and anxiety compared to patients in biochemical remission. Overall, this study provides new insights into complex attention and memory deficits in patients with CS and concern regarding cognitive and emotional issues despite resolution of hypercortisolism. Our study opens several avenues for further exploration.
journal_name
Behav Neuroljournal_title
Behavioural neurologyauthors
Na S,Fernandes MA,Ioachimescu AG,Penna Sdoi
10.1155/2020/4064370subject
Has Abstractpub_date
2020-08-07 00:00:00pages
4064370eissn
0953-4180issn
1875-8584journal_volume
2020pub_type
杂志文章abstract:Objectives:To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods:An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH. The hematoma ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/6583267
更新日期:2018-08-12 00:00:00
abstract::Cannabinoids have been used for hundred of years for medical purposes. To day, the cannabinoid delta-9-tetrahydrocannabinol (THC) and the cannabis extract nabiximols are approved for the treatment of nausea, anorexia and spasticity, respectively. In Tourette syndrome (TS) several anecdotal reports provided evidence th...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-120276
更新日期:2013-01-01 00:00:00
abstract::We report a right-handed man who developed selective Kana (phonogram) agraphia following an infarct in the non-dominant right cerebral hemisphere. His ability for comprehension, reading and writing of Kanji (ideogram) was unaffected. Kana errors consisted of substitution with another letter and the number of target wo...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1995-8208
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Thalamic lesions are seen in a multitude of disorders including vascular diseases, metabolic disorders, inflammatory diseases, trauma, tumours, and infections. In some diseases, thalamic involvement is typical and sometimes isolated, while in other diseases thalamic lesions are observed only occasionally (of...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2014/154631
更新日期:2014-01-01 00:00:00
abstract::Gaining a driver's licence represents increased independence and can lead to improved quality of life for individuals and their families. Learning to drive a motor vehicle and maintaining safe on-road skills are often more difficult for people on the autism spectrum. Many countries currently have no autism-specific li...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2018/6842306
更新日期:2018-08-28 00:00:00
abstract::Tardive dystonia was identified in 25 patients: involvement of the face and neck was most common; truncal and limb dystonia were also observed. There were 3 cases of laryngospasm and 2 of spasmodic dysphonia. The latter has not been previously reported as a manifestation of tardive dystonia. In all cases, movements ty...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1988-1106
更新日期:1988-01-01 00:00:00
abstract::A case of late onset sporadic startle syndrome in a patient with a right posterior fossa brain tumour is reported. The exaggerated startle response did not respond to treatment with clonazepam. In addition to anxiety and depression, the patient developed obsessive- compulsive symptoms which responded to behavioural th...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/1998/617160
更新日期:1998-01-01 00:00:00
abstract::All published studies on micrographia, a diminution of letter size, examine handwriting in the horizontal direction. Writing horizontally typically requires increased wrist extension as handwriting progresses from left to right. Chinese characters, however, can be written not only horizontally from left to right, but ...
journal_title:Behavioural neurology
pub_type: 杂志文章,随机对照试验
doi:10.3233/BEN-120285
更新日期:2013-01-01 00:00:00
abstract::Since the very beginning of the aphasia history it has been well established that there are two major aphasic syndromes (Wernicke's-type and Broca's-type aphasia); each one of them is related to the disturbance at a specific linguistic level (lexical/semantic and grammatical) and associated with a particular brain dam...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2015/872487
更新日期:2015-01-01 00:00:00
abstract::Neuropsychological studies of memory disorders have played a prominent role in the development of theories of memory. To test and refine such theories in future, it will be advantageous to include research that utilizes physiological measures of the neural events responsible for memory. Measures of the electrical acti...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2000/865250
更新日期:2000-01-01 00:00:00
abstract::Patients with brain function disorders due to stroke or dementia may show inability to recognize themselves in the mirror. Although the cognitive ability to recognize mirror images has been investigated in many animal species, the animal species that can be used for experimentation and the mechanisms involved in recog...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/4071315
更新日期:2020-02-03 00:00:00
abstract::Understanding the mental states of others entails a number of cognitive processes known as Theory of Mind (ToM). A relationship between ToM deficits and executive disorders has been hypothesized in individuals with Parkinson's disease (PD). The present study was aimed at investigating the effect of dysexecutive defici...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-129018
更新日期:2013-01-01 00:00:00
abstract::Subjects with Alzheimer's disease (AD) show loss of cognitive functions and change in behavioral and functional state affecting the quality of their daily life and that of their families and caregivers. A neuropsychological assessment plays a crucial role in detecting such changes from normal conditions. However, desp...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2017/1850909
更新日期:2017-01-01 00:00:00
abstract::Recent research has characterized the anatomical connectivity of the cortico-cerebellar system - a large and important fibre system in the primate brain. Within this system, there are reciprocal projections between the prefrontal cortex and Crus II of the cerebellar cortex, which both play important roles in the acqui...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2010-0267
更新日期:2010-01-01 00:00:00
abstract::Since the Korean language has two distinct writing systems, phonogram (Hangul) and ideogram (Hanja: Chinese characters), alexia can present with dissociative disturbances in reading between the two systems. A 74-year-old right-handed man presented with a prominent reading impairment in Hangul with agraphia of both Han...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2008-0211
更新日期:2008-01-01 00:00:00
abstract::Neuroimaging studies and experimental data suggest that symptoms of posttraumatic stress disorder (PTSD) are associated with dysfunctions of neural circuits linking prefrontal cortex and the limbic system that have a role in autobiographic episodic memory. High-frequency repetitive transcranial magnetic stimulation (r...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2006/793256
更新日期:2006-01-01 00:00:00
abstract::Anxiety in Parkinson's disease (aPD) is underdiagnosed, undertreated, and understudied. As many as 50% of persons diagnosed with Parkinson's disease (PD) are reported to suffer from anxiety. Current treatment is largely pharmacologic, which can result in a myriad of undesirable and unsafe side effects. The aim of this...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2019/8459579
更新日期:2019-05-02 00:00:00
abstract:OBJECTIVE:To study risk factors related to ischemic stroke (IS) in youth and the influence of sleep quality on youth ischemic stroke incidence. METHODS:223 patients aged 18 to 45 years who were admitted to Puyang People's Hospital from June 2011 to February 2013 with a first-ever ischemic stroke were selected as the r...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/246841
更新日期:2014-01-01 00:00:00
abstract::Current research supports the strong potential of structural MRI profiles, even within cross-sectional designs, as a promising method for the discrimination of Alzheimer's Disease (AD) from normal controls and for the prediction of Mild Cognitive Impairment (MCI) progression and conversion to AD. Findings suggest that...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-2009-0230
更新日期:2009-01-01 00:00:00
abstract::Frontotemporal dementia (FTD) affects behavior, language, and personality. This study aims to explore functional connectivity changes in three FTD variants: behavioral (bvFTD), semantic (svPPA), and nonfluent variant (nfvPPA). Seventy-six patients diagnosed with FTD by international criteria and thirty-two controls we...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/9684129
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The extent of brain damage in chronic stroke patients is traditionally defined as the necrotic tissue observed on magnetic resonance image (MRI). However, patients often exhibit symptoms suggesting that functional impairment may affect areas beyond the cortical necrotic lesion, for example, when cortical sym...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/215380
更新日期:2014-01-01 00:00:00
abstract::The present study is aimed at identifying the most prominent determinants of OCD along with their strength to classify the OCD patients from healthy controls. The data for this cross-sectional study were collected from 200 diagnosed OCD patients and 400 healthy controls. The respondents were selected through purposive...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/2678718
更新日期:2020-06-22 00:00:00
abstract::Eighty-five patients with idiopathic spasmodic torticollis were compared with an equally chronic group of 49 cervical spondylosis sufferers in terms of body concept, depression, and disability. The torticollis patients were significantly more depressed and disabled and had a more negative body concept. Depression had ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1990-3206
更新日期:1990-01-01 00:00:00
abstract:Background:Medication adherence and belief are crucial to achieving the desired goal of therapy in epileptic patients. However, there is a lack of study regarding medication adherence and belief in our setting. Therefore, the purpose of this study was to investigate medication adherence and belief and associated factor...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2019/2806341
更新日期:2019-04-23 00:00:00
abstract:BACKGROUND:Increasing proportion of the elderly in the driving population raises the importance of assuring their safety. We explored the effects of three different types of cognitive training on the cognitive function, brain structure, and driving safety of the elderly. METHODS:Thirty-seven healthy elderly daily driv...
journal_title:Behavioural neurology
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/525901
更新日期:2015-01-01 00:00:00
abstract::Aiming and tapping movements were analysed repeatedly over a three-week period in a patient who was hemideafferented due to an ischaemic posterior thalamic lesion. Contrasting behaviour observed in six healthy subjects, nine hemiparetic patients and one patient with hemianopic stroke, allowed the determination of beha...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1997-10103
更新日期:1997-01-01 00:00:00
abstract::We describe a cross-sectional study of aggressive behaviour in a sample of patients suffering from Huntington's disease in a residential nursing home. Data were obtained using the RAGE, a behaviourally oriented rating scale for measuring aggressive behaviour in cognitively impaired patients. Nursing staff rated 27 pat...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1993-6107
更新日期:1993-01-01 00:00:00
abstract:Background:Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) share many risk factors. Evidence suggests that metabolic risk factors are important to AD; however, their association with DLB is unclear. The risk of cardiovascular diseases (CVD) associated with AD and DLB is also uncertain. Thus, this nationwid...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/8312346
更新日期:2018-06-03 00:00:00
abstract::The term functional amnesia (FA) has been proposed for cases of memory impairment presenting with severe retrograde amnesia in the absence of cerebral injury or history of psychiatric disturbance. Emotional flattening has often been reported alongside FA, however the mechanism of such a modification is unknown. This s...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2008/245495
更新日期:2008-01-01 00:00:00
abstract::This study examined hemispatial bias in a free-viewing condition of the judgement of facial expressions of emotions. Right-handed male subjects were asked to judge the intensity, in terms of expressiveness, of facial emotion in normal and mirror-reversed orientations. Expressions in mirror-reversed orientation were pe...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1996-93-402
更新日期:1996-01-01 00:00:00