rTMS for PTSD: induced merciful oblivion or elimination of abnormal hypermnesia?

Abstract:

:Neuroimaging studies and experimental data suggest that symptoms of posttraumatic stress disorder (PTSD) are associated with dysfunctions of neural circuits linking prefrontal cortex and the limbic system that have a role in autobiographic episodic memory. High-frequency repetitive transcranial magnetic stimulation (rTMS) of the right dorsolateral prefrontal cortex (DLPFC) has been suggested to be beneficial to patients with PTSD, transiently alleviating re-experiencing as well as avoidance reactions and associated anxiety symptoms. In healthy humans, converging evidence suggests that rTMS of the right DLPFC interferes with episodic memory retrieval. Hence, we hypothesize that daily applications of rTMS in PTSD patients may reduce access to the set of autobiographical stored events, that, if re-experienced, may cause the overt PTSD symptoms.

journal_name

Behav Neurol

journal_title

Behavioural neurology

authors

Rossi S,Cappa SF,Ulivelli M,De Capua A,Bartalini S,Rossini PM

doi

10.1155/2006/793256

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

195-9

issue

3-4

eissn

0953-4180

issn

1875-8584

journal_volume

17

pub_type

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