Functional Connectivity Changes in Behavioral, Semantic, and Nonfluent Variants of Frontotemporal Dementia.

Abstract:

:Frontotemporal dementia (FTD) affects behavior, language, and personality. This study aims to explore functional connectivity changes in three FTD variants: behavioral (bvFTD), semantic (svPPA), and nonfluent variant (nfvPPA). Seventy-six patients diagnosed with FTD by international criteria and thirty-two controls were investigated. Functional connectivity from resting functional magnetic resonance imaging (fMRI) was estimated for the whole brain. Two types of analysis were done: network basic statistic and topological measures by graph theory. Several hubs in the limbic system and basal ganglia were compromised in the behavioral variant apart from frontal networks. Nonfluent variants showed a major disconnection with respect to the behavioral variant in operculum and parietal inferior. The global efficiency had lower coefficients in nonfluent variants than behavioral variants and controls. Our results support an extensive disconnection among frontal, limbic, basal ganglia, and parietal hubs.

journal_name

Behav Neurol

journal_title

Behavioural neurology

authors

Reyes P,Ortega-Merchan MP,Rueda A,Uriza F,Santamaria-García H,Rojas-Serrano N,Rodriguez-Santos J,Velasco-Leon MC,Rodriguez-Parra JD,Mora-Diaz DE,Matallana D

doi

10.1155/2018/9684129

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

9684129

eissn

0953-4180

issn

1875-8584

journal_volume

2018

pub_type

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