Abstract:
BACKGROUND:Increasing proportion of the elderly in the driving population raises the importance of assuring their safety. We explored the effects of three different types of cognitive training on the cognitive function, brain structure, and driving safety of the elderly. METHODS:Thirty-seven healthy elderly daily drivers were randomly assigned to one of three training groups: Group V trained in a vehicle with a newly developed onboard cognitive training program, Group P trained with a similar program but on a personal computer, and Group C trained to solve a crossword puzzle. Before and after the 8-week training period, they underwent neuropsychological tests, structural brain magnetic resonance imaging, and driving safety tests. RESULTS:For cognitive function, only Group V showed significant improvements in processing speed and working memory. For driving safety, Group V showed significant improvements both in the driving aptitude test and in the on-road evaluations. Group P showed no significant improvements in either test, and Group C showed significant improvements in the driving aptitude but not in the on-road evaluations. CONCLUSION:The results support the effectiveness of the onboard training program in enhancing the elderly's abilities to drive safely and the potential advantages of a multimodal training approach.
journal_name
Behav Neuroljournal_title
Behavioural neurologyauthors
Nozawa T,Taki Y,Kanno A,Akimoto Y,Ihara M,Yokoyama R,Kotozaki Y,Nouchi R,Sekiguchi A,Takeuchi H,Miyauchi CM,Ogawa T,Goto T,Sunda T,Shimizu T,Tozuka E,Hirose S,Nanbu T,Kawashima Rdoi
10.1155/2015/525901subject
Has Abstractpub_date
2015-01-01 00:00:00pages
525901eissn
0953-4180issn
1875-8584journal_volume
2015pub_type
杂志文章,随机对照试验abstract::Eighty-five patients with idiopathic spasmodic torticollis were compared with an equally chronic group of 49 cervical spondylosis sufferers in terms of body concept, depression, and disability. The torticollis patients were significantly more depressed and disabled and had a more negative body concept. Depression had ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1990-3206
更新日期:1990-01-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) was used to study the neural correlates of neutral, stressful, negative and positive autobiographical memories. The brain activity produced by these different kinds of episodic memory did not differ significantly, but a common pattern of activation for different kinds of au...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2005/460745
更新日期:2005-01-01 00:00:00
abstract::Neuroimaging studies and experimental data suggest that symptoms of posttraumatic stress disorder (PTSD) are associated with dysfunctions of neural circuits linking prefrontal cortex and the limbic system that have a role in autobiographic episodic memory. High-frequency repetitive transcranial magnetic stimulation (r...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2006/793256
更新日期:2006-01-01 00:00:00
abstract::The serum concentration achieved and maintained following the administration of a fixed drug dosage is a direct consequence of the interactions of a wide variety of interrelated processes, including drug absorption, distribution, metabolism, and excretion, and the physiological status of the patient. These interrelati...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1990-31S102
更新日期:1990-01-01 00:00:00
abstract::This report presents a syndrome resembling obsessive convulsive disorder (OCD) secondary to a stroke in the left basal ganglia. The patient's syndrome is virtually identical to those that have been described in bilateral damage of the basal ganglia. However, the stroke described in this case report is located unilater...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1997-102-308
更新日期:1997-01-01 00:00:00
abstract::Since the very beginning of the aphasia history it has been well established that there are two major aphasic syndromes (Wernicke's-type and Broca's-type aphasia); each one of them is related to the disturbance at a specific linguistic level (lexical/semantic and grammatical) and associated with a particular brain dam...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2015/872487
更新日期:2015-01-01 00:00:00
abstract:Objective:The aim of this study is to explore the relationship between neuron-specific enolase (NSE) gene polymorphism and delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) and provide a theoretical basis for DEACMP pathogenesis, diagnosis, and prognosis. Methods:To investigate this relationship, w...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/8819210
更新日期:2020-10-14 00:00:00
abstract::Cognitive impairment is frequently encountered in multiple sclerosis (MS) affecting between 40-65% of individuals, irrespective of disease duration and severity of physical disability. In the present multicenter randomized controlled trial, fifty-eight clinically stable RRMS patients with mild to moderate cognitive im...
journal_title:Behavioural neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1155/2017/5919841
更新日期:2017-01-01 00:00:00
abstract::We describe a right-handed patient who suffered a ruptured aneurysm of the anterior communicating artery (ACoA) which was clipped successfully. Computerized tomography indicated a low density area in the genu of the corpus callosum and the infero-lateral aspect of the left frontal lobe. On recovery the patient's most ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1991-4305
更新日期:1991-01-01 00:00:00
abstract::All published studies on micrographia, a diminution of letter size, examine handwriting in the horizontal direction. Writing horizontally typically requires increased wrist extension as handwriting progresses from left to right. Chinese characters, however, can be written not only horizontally from left to right, but ...
journal_title:Behavioural neurology
pub_type: 杂志文章,随机对照试验
doi:10.3233/BEN-120285
更新日期:2013-01-01 00:00:00
abstract::Introduction. Antiepileptic drugs are effective in the treatment of epilepsy to the extent that about 70% of people with epilepsy can be seizure-free, but poor adherence to medication is major problem to sustained remission and functional restoration. The aim of this study was to assess the prevalence and associated f...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2016/3189108
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To study risk factors related to ischemic stroke (IS) in youth and the influence of sleep quality on youth ischemic stroke incidence. METHODS:223 patients aged 18 to 45 years who were admitted to Puyang People's Hospital from June 2011 to February 2013 with a first-ever ischemic stroke were selected as the r...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/246841
更新日期:2014-01-01 00:00:00
abstract::Thirteen patients with idiopathic Parkinson's disease of recent onset (mean age 63·2 years) and a group of 10 young healthy volunteers (mean age 26·1 years) underwent a series of neuropsychological tests for assessment of memory, learning ability and mental processing speed before and during treatment with trihexyphen...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1991-4206
更新日期:1991-01-01 00:00:00
abstract::Patients with Cushing's syndrome (CS) in remission often suffer from impaired quality of life and cognitive dysfunction. The primary aim was to investigate the occurrence of mental fatigue, characterized by mental exhaustion and long recovery time following mentally strenuous tasks, in patients with CS in remission. T...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/173653
更新日期:2015-01-01 00:00:00
abstract::Subjects with Alzheimer's disease (AD) show loss of cognitive functions and change in behavioral and functional state affecting the quality of their daily life and that of their families and caregivers. A neuropsychological assessment plays a crucial role in detecting such changes from normal conditions. However, desp...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2017/1850909
更新日期:2017-01-01 00:00:00
abstract::What distinguishes the recall of real-life experiences from that of self-created, fictitious emotionally laden information? Both kinds of information belong to the episodic memory system. Autobiographic memories constitute that part of the episodic memory system that is composed of significant life episodes, primarily...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2000/303651
更新日期:2000-01-01 00:00:00
abstract::Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography (PET) with (11)carbon-labelled Pittsburgh Compound-B ((11)C-PIB), ...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-2009-0232
更新日期:2009-01-01 00:00:00
abstract::When assessing for the presence of hemianesthesia, the examiner touches the body of the patients, and requests that they report verbally the location of the delivered tactile stimulus. Contralesional omissions of single tactile stimuli, however, might be due to either primary somatosensory deficits or to spatial atten...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2012-110225
更新日期:2013-01-01 00:00:00
abstract:Background:Epilepsy is a chronic neurological disorder characterized by unprovoked recurrent seizure episodes. The disease has detrimental effects on social, cognitive, psychological, and physical components of life consequently quality of life of the patients. The level of the effect of the disease on quality life is ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/7593573
更新日期:2018-12-02 00:00:00
abstract::Current research supports the strong potential of structural MRI profiles, even within cross-sectional designs, as a promising method for the discrimination of Alzheimer's Disease (AD) from normal controls and for the prediction of Mild Cognitive Impairment (MCI) progression and conversion to AD. Findings suggest that...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-2009-0230
更新日期:2009-01-01 00:00:00
abstract::Patients with unilateral neglect are impaired at making saccades to contralesional targets. Whether this problem arises from a deficit in perception, in planning the saccade or in executing the eye movement or some combination thereof remains unclear. We measured several variables related to the initiation and executi...
journal_title:Behavioural neurology
pub_type: 临床试验,杂志文章
doi:10.1155/2002/253201
更新日期:2001-01-01 00:00:00
abstract::There is paucity of computed tomography (CT) studies from developing countries, where schizophrenia is said to have more favourable outcome and present predominantly with positive symptoms. We highlight the densitometric analysis of frontal and parietal areas, assessed by tracing of regions of interest on the slice th...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1995-8104
更新日期:1995-01-01 00:00:00
abstract::We present a patient who developed severe ideomotor apraxia (IA) and subcortical aphasia after a hemorrhage involving the posterior part of the left thalamus and the posterior limb of the internal capsule. The cerebral blood flow (CBF) of the left hemisphere as measured by 99Tc-HM-PAO SPECT was initially diminished as...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1991-4102
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Thalamic lesions are seen in a multitude of disorders including vascular diseases, metabolic disorders, inflammatory diseases, trauma, tumours, and infections. In some diseases, thalamic involvement is typical and sometimes isolated, while in other diseases thalamic lesions are observed only occasionally (of...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2014/154631
更新日期:2014-01-01 00:00:00
abstract::Three points of interest lie in considering how Alzheimer, and more significantly Perusini, struggled to throw light on the cause of this devastating disease. There is a stimulating possibility that Perusini believed presenile forms of Alzheimer's disease described the same disease as senile forms. If so this would an...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1997-10401
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Poststroke depression (PSD) is a common complication after stroke. There is no adequate treatment for PSD. This study examined efficacy of cognitive rehabilitation therapy (CRT) in the treatment of PSD among stroke survivors. METHODS:An experimental design, 30 participants with poststroke depres...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2017/4058124
更新日期:2017-01-01 00:00:00
abstract::Norepinephrine and dopamine are both believed to affect signal-to-noise in the cerebral cortex. Dopaminergic agents appear to modulate semantic networks during indirect semantic priming, but do not appear to affect problem solving dependent on access to semantic networks. Noradrenergic agents, though, do affect semant...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2009-0236
更新日期:2009-01-01 00:00:00
abstract::Psychogenic amnesia is a complex disorder characterised by a wide variety of symptoms. Consequently, in a number of cases it is difficult distinguish it from organic memory impairment. The present study reports a new case of global psychogenic amnesia compared with two patients with amnesia underlain by organic brain ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2007/193140
更新日期:2007-01-01 00:00:00
abstract:Objective:To explore the effects of sevoflurane on the latency and error times of the passive avoidance and levels of PSD-95 and AMPA receptors in the hippocampus. We evaluated the effects of sevoflurane on short-term memory in adult mice and explored the possible mechanism. Methods:144 Kunming mice (2-3 months, 30-35...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2019/1068260
更新日期:2019-10-21 00:00:00
abstract::Dementia with Lewy bodies (DLB) is the second most common degenerative dementia of the central nervous system. The technique 18F-fluorodeoxyglucose positron emission tomography (18F FDG PET) was used to investigate brain metabolism patterns in DLB patients. Conventional statistical methods did not consider intern meta...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/8420658
更新日期:2018-05-08 00:00:00