Lack of selective vulnerability to anticholinergic induced cognitive impairment in early Parkinson's disease.

Abstract:

:Thirteen patients with idiopathic Parkinson's disease of recent onset (mean age 63·2 years) and a group of 10 young healthy volunteers (mean age 26·1 years) underwent a series of neuropsychological tests for assessment of memory, learning ability and mental processing speed before and during treatment with trihexyphenidyl. Retesting after anticholinergic exposure (mean of 2 weeks for patients and 1 week for controls) revealed in young healthy controls the same pattern and magnitude of decline in memory function as in Parkinson patients. Non-demented subjects with Parkinson's disease of recent onset thus do riot seem to be selectively vulnerable to cognitive side-effects of anticholinergic treatment.

journal_name

Behav Neurol

journal_title

Behavioural neurology

authors

Schelosky L,Benke T,Poewe W

doi

10.3233/BEN-1991-4206

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

103-11

issue

2

eissn

0953-4180

issn

1875-8584

pii

R6318X6021157R72

journal_volume

4

pub_type

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