Mapping remote subcortical ramifications of injury after ischemic strokes.

Abstract:

BACKGROUND:The extent of brain damage in chronic stroke patients is traditionally defined as the necrotic tissue observed on magnetic resonance image (MRI). However, patients often exhibit symptoms suggesting that functional impairment may affect areas beyond the cortical necrotic lesion, for example, when cortical symptoms ensue after subcortical damage. This observation suggests that disconnection or diaschisis can lead to remote cortical dysfunction that can be functionally equivalent to direct cortical lesions. Objective. To directly measure subcortical disconnection after stroke. METHODS:We describe a principled approach utilizing the whole brain connectome reconstructed from diffusion MRI to evaluate the reduction of apparent white matter fiber density in the hemisphere affected by the stroke compared with the spared hemisphere. RESULTS:In eight chronic stroke patients, we observed subcortical disconnection extending beyond the location of tissue necrosis and affecting major white matter pathways underlying the necrotic area. CONCLUSIONS:We suggest that it is possible to detect and quantify previously unappreciated areas of subcortical and cortical disconnection. Specifically, this method can be used to evaluate the relationship between lesion location and symptoms, with emphasis on a connectivity-based approach.

journal_name

Behav Neurol

journal_title

Behavioural neurology

authors

Bonilha L,Nesland T,Rorden C,Fillmore P,Ratnayake RP,Fridriksson J

doi

10.1155/2014/215380

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

215380

eissn

0953-4180

issn

1875-8584

journal_volume

2014

pub_type

杂志文章
  • Lack of noradrenergic modulation of indirect semantic priming.

    abstract::Norepinephrine and dopamine are both believed to affect signal-to-noise in the cerebral cortex. Dopaminergic agents appear to modulate semantic networks during indirect semantic priming, but do not appear to affect problem solving dependent on access to semantic networks. Noradrenergic agents, though, do affect semant...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-2009-0236

    authors: Cios JS,Miller RF,Hillier A,Tivarus ME,Beversdorf DQ

    更新日期:2009-01-01 00:00:00

  • Unpicking the semantic impairment in Alzheimer's disease: qualitative changes with disease severity.

    abstract::Despite a vast literature examining semantic impairment in Alzheimer's disease (AD), consensus regarding the nature of the deficit remains elusive. We re-considered this issue in the context of a framework that assumes semantic cognition can break down in two ways: (1) core semantic representations can degrade or (2) ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-2012-0346

    authors: Corbett F,Jefferies E,Burns A,Ralph MA

    更新日期:2012-01-01 00:00:00

  • Is there a place for ipsilesional eye patching in neglect rehabilitation?

    abstract::Neglect behavior of experimental animals with unilateral posterior cortical lesions improves with the placement of a second lesion in the contralesional superior colliculus or in the intercollicular commissure. Given that the retinotectal fibers are mainly crossed, it has been speculated that ipsilesional eye patching...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1994-73-408

    authors: Soroker N,Cohen T,Baratz C,Glicksohn J,Myslobodsky MS

    更新日期:1994-01-01 00:00:00

  • Analysis of HMPAO SPECT scans in head injury using Statistical Parametric Mapping.

    abstract::The paper examines the ability of Statistical Parametric Mapping (SPM) to contribute towards the quantitative analysis of HMPAO SPECT images containing lesions. A validation study is described in which SPECT images were created that contained synthetic lesions and were analysed with SPM. The study established a set of...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2000/681916

    authors: Stamatakis EA,Wilson JT,Wyper DJ

    更新日期:2000-01-01 00:00:00

  • Dementia of frontal lobe type and amyotrophy.

    abstract::Dementia of frontal lobe type may precede motor signs in a number of adult patients with amyotrophy. Neuropathological studies have shown neuron loss, spongiosis and gliosis mainly in layers II and III of the frontal and temporal lobes, together with myelin pallor of the subcortical white matter. Golgi studies reveale...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1992-5204

    authors: Ferrer I

    更新日期:1992-01-01 00:00:00

  • Undifferentiation of somatic responses to emotions in a case of functional amnesia.

    abstract::The term functional amnesia (FA) has been proposed for cases of memory impairment presenting with severe retrograde amnesia in the absence of cerebral injury or history of psychiatric disturbance. Emotional flattening has often been reported alongside FA, however the mechanism of such a modification is unknown. This s...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2008/245495

    authors: Tramoni E,Khalfa S,Felician O,Trebuchon-Da Fonseca A,Poncet M,Ceccaldi M

    更新日期:2008-01-01 00:00:00

  • Effects of Different Types of Cognitive Training on Cognitive Function, Brain Structure, and Driving Safety in Senior Daily Drivers: A Pilot Study.

    abstract:BACKGROUND:Increasing proportion of the elderly in the driving population raises the importance of assuring their safety. We explored the effects of three different types of cognitive training on the cognitive function, brain structure, and driving safety of the elderly. METHODS:Thirty-seven healthy elderly daily driv...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2015/525901

    authors: Nozawa T,Taki Y,Kanno A,Akimoto Y,Ihara M,Yokoyama R,Kotozaki Y,Nouchi R,Sekiguchi A,Takeuchi H,Miyauchi CM,Ogawa T,Goto T,Sunda T,Shimizu T,Tozuka E,Hirose S,Nanbu T,Kawashima R

    更新日期:2015-01-01 00:00:00

  • Mirror-reversal of a face is perceived as expressing emotions more intensely.

    abstract::This study examined hemispatial bias in a free-viewing condition of the judgement of facial expressions of emotions. Right-handed male subjects were asked to judge the intensity, in terms of expressiveness, of facial emotion in normal and mirror-reversed orientations. Expressions in mirror-reversed orientation were pe...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1996-93-402

    authors: Asthana HS,Mandal MK

    更新日期:1996-01-01 00:00:00

  • Right amygdalar and temporofrontal activation during autobiographic, but not during fictitious memory retrieval.

    abstract::What distinguishes the recall of real-life experiences from that of self-created, fictitious emotionally laden information? Both kinds of information belong to the episodic memory system. Autobiographic memories constitute that part of the episodic memory system that is composed of significant life episodes, primarily...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2000/303651

    authors: Markowitsch HJ,Thiel A,Reinkemeier M,Kessler J,Koyuncu A,Heiss WD

    更新日期:2000-01-01 00:00:00

  • Emotional processing following cortical and subcortical brain damage: contribution of the fronto-striatal circuitry.

    abstract::The present study examined the differential contribution of cortical and subcortical brain structures in emotional processing by comparing patients with focal cortical lesions (n = 32) to those with primarily subcortical dysregulation of the basal ganglia (Parkinson's disease n = 14). A standardized measure of emotion...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/1998/579029

    authors: Breitenstein C,Daum I,Ackermann H

    更新日期:1998-01-01 00:00:00

  • Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo.

    abstract::Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography (PET) with (11)carbon-labelled Pittsburgh Compound-B ((11)C-PIB), ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.3233/BEN-2009-0232

    authors: Rabinovici GD,Jagust WJ

    更新日期:2009-01-01 00:00:00

  • Mediational Model of Multiple Sclerosis Impairments, Family Needs, and Caregiver Mental Health in Guadalajara, Mexico.

    abstract::Individuals with multiple sclerosis (MS), especially those living in Latin America, often require assistance from family caregivers throughout the duration of the disease. Previous research suggests that family caregivers may experience positive and negative outcomes from providing care to individuals with MS, but few...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2018/8929735

    authors: Mickens MN,Perrin PB,Aguayo A,Rabago B,Macías-Islas MA,Arango-Lasprilla JC

    更新日期:2018-01-17 00:00:00

  • Scoping Review of the Driving Behaviour of and Driver Training Programs for People on the Autism Spectrum.

    abstract::Gaining a driver's licence represents increased independence and can lead to improved quality of life for individuals and their families. Learning to drive a motor vehicle and maintaining safe on-road skills are often more difficult for people on the autism spectrum. Many countries currently have no autism-specific li...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.1155/2018/6842306

    authors: Wilson NJ,Lee HC,Vaz S,Vindin P,Cordier R

    更新日期:2018-08-28 00:00:00

  • Computed tomographic density changes in schizophrenic and manic Nigerian subjects.

    abstract::There is paucity of computed tomography (CT) studies from developing countries, where schizophrenia is said to have more favourable outcome and present predominantly with positive symptoms. We highlight the densitometric analysis of frontal and parietal areas, assessed by tracing of regions of interest on the slice th...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1995-8104

    authors: Ohaeri JU,Adeyinka AO,Osuntokun BO

    更新日期:1995-01-01 00:00:00

  • Event related potentials and serial list picture memory in Parkinson's patients.

    abstract::Two experiments examined short-term memory for order information in six patients diagnosed with Parkinson's disease (PD) and six control subjects while event related potentials (ERPs) were recorded. The subjects were tested for recognition of abstract spatial designs and words after a 5 s retention interval. The PD pa...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1996-9203

    authors: Korsnes MS,Reinvang I

    更新日期:1996-01-01 00:00:00

  • Regional MRI perfusion measures predict motor/executive function in patients with clinically isolated syndrome.

    abstract:BACKGROUND:Patients with clinically isolated syndrome (CIS) demonstrate brain hemodynamic changes and also suffer from difficulties in processing speed, memory, and executive functions. OBJECTIVE:To explore whether brain hemodynamic disturbances in CIS patients correlate with executive functions. METHODS:Thirty CIS p...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2014/252419

    authors: Papadaki EZ,Simos PG,Mastorodemos VC,Panou T,Maris TG,Karantanas AH,Plaitakis A

    更新日期:2014-01-01 00:00:00

  • Late-onset startle syndrome and obsessive compulsive disorder.

    abstract::A case of late onset sporadic startle syndrome in a patient with a right posterior fossa brain tumour is reported. The exaggerated startle response did not respond to treatment with clonazepam. In addition to anxiety and depression, the patient developed obsessive- compulsive symptoms which responded to behavioural th...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/1998/617160

    authors: Gonzalez A,Philpot MP

    更新日期:1998-01-01 00:00:00

  • Nonpharmacologic Interventions for the Self-Management of Anxiety in Parkinson's Disease: A Comprehensive Review.

    abstract::Anxiety in Parkinson's disease (aPD) is underdiagnosed, undertreated, and understudied. As many as 50% of persons diagnosed with Parkinson's disease (PD) are reported to suffer from anxiety. Current treatment is largely pharmacologic, which can result in a myriad of undesirable and unsafe side effects. The aim of this...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.1155/2019/8459579

    authors: Chandler SK,Robins JL,Kinser PA

    更新日期:2019-05-02 00:00:00

  • Progressive micrographia shown in horizontal, but not vertical, writing in Parkinson's disease.

    abstract::All published studies on micrographia, a diminution of letter size, examine handwriting in the horizontal direction. Writing horizontally typically requires increased wrist extension as handwriting progresses from left to right. Chinese characters, however, can be written not only horizontally from left to right, but ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/BEN-120285

    authors: Ma HI,Hwang WJ,Chang SH,Wang TY

    更新日期:2013-01-01 00:00:00

  • Cerebellar information processing in relapsing-remitting multiple sclerosis (RRMS).

    abstract::Recent research has characterized the anatomical connectivity of the cortico-cerebellar system - a large and important fibre system in the primate brain. Within this system, there are reciprocal projections between the prefrontal cortex and Crus II of the cerebellar cortex, which both play important roles in the acqui...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-2010-0267

    authors: Lesage E,Apps MA,Hayter AL,Beckmann CF,Barnes D,Langdon DW,Ramnani N

    更新日期:2010-01-01 00:00:00

  • Therapy efficacy in chronic aphasia.

    abstract::There is good evidence that aphasia therapy is effective if sufficiently prolonged or intensive and that chronic aphasic individuals can also benefit from therapy, but data on chronic aphasia are scanty. The aim of this retrospective study was to investigate whether chronic aphasia benefits from a very intensive thera...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-2011-0342

    authors: Basso A,Macis M

    更新日期:2011-01-01 00:00:00

  • Voice recognition impairment in a blind Capgras patient.

    abstract::We report a case of a blind woman, M.N., who experienced the Capgras delusion. She thought that her pet cat had been replaced by a replica which was "ill-intentioned" towards her. M.N.'s case shows that the basis of the Capgras delusion cannot lie exclusively in damage to the visual system. However, testing of M.N.'s ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1993-6409

    authors: Reid I,Young AW,Hellawell DJ

    更新日期:1993-01-01 00:00:00

  • Mental Fatigue and Executive Dysfunction in Patients with Cushing's Syndrome in Remission.

    abstract::Patients with Cushing's syndrome (CS) in remission often suffer from impaired quality of life and cognitive dysfunction. The primary aim was to investigate the occurrence of mental fatigue, characterized by mental exhaustion and long recovery time following mentally strenuous tasks, in patients with CS in remission. T...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2015/173653

    authors: Papakokkinou E,Johansson B,Berglund P,Ragnarsson O

    更新日期:2015-01-01 00:00:00

  • Functional Connectivity Changes in Behavioral, Semantic, and Nonfluent Variants of Frontotemporal Dementia.

    abstract::Frontotemporal dementia (FTD) affects behavior, language, and personality. This study aims to explore functional connectivity changes in three FTD variants: behavioral (bvFTD), semantic (svPPA), and nonfluent variant (nfvPPA). Seventy-six patients diagnosed with FTD by international criteria and thirty-two controls we...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2018/9684129

    authors: Reyes P,Ortega-Merchan MP,Rueda A,Uriza F,Santamaria-García H,Rojas-Serrano N,Rodriguez-Santos J,Velasco-Leon MC,Rodriguez-Parra JD,Mora-Diaz DE,Matallana D

    更新日期:2018-04-01 00:00:00

  • Studying social cognition in patients with schizophrenia and patients with frontotemporal dementia: theory of mind and the perception of sarcasm.

    abstract::We investigated social cognition and theory of mind in patients with schizophrenia and in patients with frontotemporal dementia in order to elucidate the cognitive mechanisms involved in the breakdown of these skills in psychiatric and neurological patients. Our tasks included videotaped scenarios of social interactio...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2008/157356

    authors: Kosmidis MH,Aretouli E,Bozikas VP,Giannakou M,Ioannidis P

    更新日期:2008-01-01 00:00:00

  • Completion phenomenon in transcortical sensory aphasia.

    abstract::We investigated completion phenomenon for proverbs in cases demonstrating transcortical sensory aphasia due to a variety of diseases. Lack of this completion was exclusively observed in patients with focal atrophy. These patients showed a selective and consistent impairment in word comprehension without phonemic cue e...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1993-6304

    authors: Nakagawa Y,Tanabe H,Ikeda M,Kazui H,Ito K,Inoue N,Hatakenaka Y,Sawada T,Ikeda H,Shiraishi J

    更新日期:1993-01-01 00:00:00

  • Ideomotor Apraxia in Left Thalamic Hemorrhage: Discrepancy between Clinical Course and SPECT.

    abstract::We present a patient who developed severe ideomotor apraxia (IA) and subcortical aphasia after a hemorrhage involving the posterior part of the left thalamus and the posterior limb of the internal capsule. The cerebral blood flow (CBF) of the left hemisphere as measured by 99Tc-HM-PAO SPECT was initially diminished as...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1991-4102

    authors: Schnider A,Landis T,Rösler HR

    更新日期:1991-01-01 00:00:00

  • Body concept, disability, and depression in patients with spasmodic torticollis.

    abstract::Eighty-five patients with idiopathic spasmodic torticollis were compared with an equally chronic group of 49 cervical spondylosis sufferers in terms of body concept, depression, and disability. The torticollis patients were significantly more depressed and disabled and had a more negative body concept. Depression had ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1990-3206

    authors: Jahanshahi M,Marsden CD

    更新日期:1990-01-01 00:00:00

  • Tardive dystonia: clinical spectrum and novel manifestations.

    abstract::Tardive dystonia was identified in 25 patients: involvement of the face and neck was most common; truncal and limb dystonia were also observed. There were 3 cases of laryngospasm and 2 of spasmodic dysphonia. The latter has not been previously reported as a manifestation of tardive dystonia. In all cases, movements ty...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1988-1106

    authors: Davis RJ,Cummings JL,Hierholzer RW

    更新日期:1988-01-01 00:00:00

  • Sexual Satisfaction in Fully Ambulatory People with Multiple Sclerosis: Does Disability Matter?

    abstract::Primary sexual dysfunctions (SD) are a direct result of neurological changes that affect the sexual response. Secondary SD result from the symptoms that do not directly involve nervous pathways to the genital system, such as bladder and bowel problems, fatigue, spasticity, or muscle weakness. Tertiary SD are the resul...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2020/8857516

    authors: Dobrakowski P,Machowska-Majchrzak A,Labuz-Roszak B,Niewiadomska E,Pierzchala K

    更新日期:2020-10-10 00:00:00