Abstract:
:Despite a vast literature examining semantic impairment in Alzheimer's disease (AD), consensus regarding the nature of the deficit remains elusive. We re-considered this issue in the context of a framework that assumes semantic cognition can break down in two ways: (1) core semantic representations can degrade or (2) cognitive control mechanisms can become impaired. We hypothesised and confirmed that the nature of semantic impairment in AD changes with disease severity. Patients at mild or severe stages of the disorder exhibited impairment across various semantic tasks but the nature of those deficits differed qualitatively for the two groups. Commensurate with early dysfunction of the cognitive control, temporoparietal-frontal-cingulate network, characteristics of deregulated semantic cognition were exhibited by the mild AD cases. In contrast, the severe AD group reproduced features of additional degradation of core semantic representations. These results suggest that spread of pathology into lateral anterior temporal lobes in later stage AD produces degradation of semantic representations, exacerbating the already deregulated system. Moreover, the dual nature of severe patients' impairment was highlighted by disproportionately poor performance on tasks placing high demand on both conceptual knowledge and control processes--e.g., category fluency.
journal_name
Behav Neuroljournal_title
Behavioural neurologyauthors
Corbett F,Jefferies E,Burns A,Ralph MAdoi
10.3233/BEN-2012-0346subject
Has Abstractpub_date
2012-01-01 00:00:00pages
23-34issue
1eissn
0953-4180issn
1875-8584pii
962TL159847548V5journal_volume
25pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:Impaired cardiac function can adversely affect the brain via decreased perfusion. The purpose of this study was to determine if cardiac ejection fraction (EF) is associated with cognitive performance, and whether this is modified by low blood pressure. METHODS:Neuropsychological testing evaluati...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2009-0261
更新日期:2010-01-01 00:00:00
abstract::Cannabinoids have been used for hundred of years for medical purposes. To day, the cannabinoid delta-9-tetrahydrocannabinol (THC) and the cannabis extract nabiximols are approved for the treatment of nausea, anorexia and spasticity, respectively. In Tourette syndrome (TS) several anecdotal reports provided evidence th...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-120276
更新日期:2013-01-01 00:00:00
abstract::Psychogenic amnesia is a complex disorder characterised by a wide variety of symptoms. Consequently, in a number of cases it is difficult distinguish it from organic memory impairment. The present study reports a new case of global psychogenic amnesia compared with two patients with amnesia underlain by organic brain ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2007/193140
更新日期:2007-01-01 00:00:00
abstract::Primary sexual dysfunctions (SD) are a direct result of neurological changes that affect the sexual response. Secondary SD result from the symptoms that do not directly involve nervous pathways to the genital system, such as bladder and bowel problems, fatigue, spasticity, or muscle weakness. Tertiary SD are the resul...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/8857516
更新日期:2020-10-10 00:00:00
abstract::A déjà vu experience is a dissociative phenomenon, which can be characterized as a subjectively inappropriate impression of familiarity of the present with an undefined past. This paper reviews empirical studies on déjà vu experiences and summarizes the most salient findings. Overall, the findings appear to be inconsi...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1992-5303
更新日期:1992-01-01 00:00:00
abstract::The importance of tools for the measurement of outcomes and needs in traumatic brain injury is well recognised. The development of tools for these injuries in indigenous communities has been limited despite the well-documented disparity of brain injury. The wairua theory of traumatic brain injury (TBI) in Māori propos...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/137402
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Thalamic lesions are seen in a multitude of disorders including vascular diseases, metabolic disorders, inflammatory diseases, trauma, tumours, and infections. In some diseases, thalamic involvement is typical and sometimes isolated, while in other diseases thalamic lesions are observed only occasionally (of...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2014/154631
更新日期:2014-01-01 00:00:00
abstract::While several studies have detected raised levels of neurological soft signs in patients with obsessive compulsive disorder (OCD), the specificity of these abnormalities remains uncertain. This study used a new standardised measure, the Cambridge Neurological Inventory (CNI), to assess soft signs in 51 subjects with O...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/1999/639045
更新日期:1998-01-01 00:00:00
abstract::Current research supports the strong potential of structural MRI profiles, even within cross-sectional designs, as a promising method for the discrimination of Alzheimer's Disease (AD) from normal controls and for the prediction of Mild Cognitive Impairment (MCI) progression and conversion to AD. Findings suggest that...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-2009-0230
更新日期:2009-01-01 00:00:00
abstract::This paper critically examines three strands of evidence that concern the relationship between type A behaviours and coronary heart disease; prospective epidemiological studies of healthy populations, studies of those at high risk for coronary heart disease, and angiographic studies of atherosclerosis. The first of th...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1990-3405
更新日期:1990-01-01 00:00:00
abstract::We investigated completion phenomenon for proverbs in cases demonstrating transcortical sensory aphasia due to a variety of diseases. Lack of this completion was exclusively observed in patients with focal atrophy. These patients showed a selective and consistent impairment in word comprehension without phonemic cue e...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1993-6304
更新日期:1993-01-01 00:00:00
abstract::The paper examines the ability of Statistical Parametric Mapping (SPM) to contribute towards the quantitative analysis of HMPAO SPECT images containing lesions. A validation study is described in which SPECT images were created that contained synthetic lesions and were analysed with SPM. The study established a set of...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2000/681916
更新日期:2000-01-01 00:00:00
abstract::Patients with Cushing's syndrome (CS) frequently report impairments in cognitive and emotional functioning. Given neuroimaging research that implicates alterations in structure and function in the brain in this population, goals of this study were to investigate neuropsychological and emotional functioning, with parti...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/4064370
更新日期:2020-08-07 00:00:00
abstract:Background:Epilepsy is a chronic neurological disorder characterized by unprovoked recurrent seizure episodes. The disease has detrimental effects on social, cognitive, psychological, and physical components of life consequently quality of life of the patients. The level of the effect of the disease on quality life is ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/7593573
更新日期:2018-12-02 00:00:00
abstract::Aiming and tapping movements were analysed repeatedly over a three-week period in a patient who was hemideafferented due to an ischaemic posterior thalamic lesion. Contrasting behaviour observed in six healthy subjects, nine hemiparetic patients and one patient with hemianopic stroke, allowed the determination of beha...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1997-10103
更新日期:1997-01-01 00:00:00
abstract:Objectives:To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods:An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH. The hematoma ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/6583267
更新日期:2018-08-12 00:00:00
abstract::Presently, there are no valid biomarkers to identify individuals with eating disorders (ED). The aim of this work was to assess the feasibility of a machine learning method for extracting reliable neuroimaging features allowing individual categorization of patients with ED. Support Vector Machine (SVM) technique, comb...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/924814
更新日期:2015-01-01 00:00:00
abstract::Visual reaction time (RT) studies on patients with right hemisphere (RH) damage have demonstrated that the attentional imbalance to stimuli occupying left and right positions exists even within the "intact" ipsilesional hemifield. The purpose of the present study was to test whether such patients might also exhibit re...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1994-7204
更新日期:1994-01-01 00:00:00
abstract::The present study is aimed at identifying the most prominent determinants of OCD along with their strength to classify the OCD patients from healthy controls. The data for this cross-sectional study were collected from 200 diagnosed OCD patients and 400 healthy controls. The respondents were selected through purposive...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/2678718
更新日期:2020-06-22 00:00:00
abstract::Recent research has characterized the anatomical connectivity of the cortico-cerebellar system - a large and important fibre system in the primate brain. Within this system, there are reciprocal projections between the prefrontal cortex and Crus II of the cerebellar cortex, which both play important roles in the acqui...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2010-0267
更新日期:2010-01-01 00:00:00
abstract::Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography (PET) with (11)carbon-labelled Pittsburgh Compound-B ((11)C-PIB), ...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-2009-0232
更新日期:2009-01-01 00:00:00
abstract::Since the Korean language has two distinct writing systems, phonogram (Hangul) and ideogram (Hanja: Chinese characters), alexia can present with dissociative disturbances in reading between the two systems. A 74-year-old right-handed man presented with a prominent reading impairment in Hangul with agraphia of both Han...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2008-0211
更新日期:2008-01-01 00:00:00
abstract::We investigated the evolution of the neurological and neuropsychological characteristics in a right-handed woman who was 53-years-old at the onset and who showed personality changes and behavioral disorders accompanied by progressive dysarthria. She had hypernasality and a slow rate of speech with distorted consonants...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2006/320638
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Apathy and reduced emotion-based decision-making are two behavioral modifications independently described in Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). OBJECTIVES:The aims of this study were to investigate decision-making based on emotional feedback processing in AD and aMCI and...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/231469
更新日期:2014-01-01 00:00:00
abstract::Physiological behaviours such as the sleep-wake cycle and exploratory behaviours are important parameters in intact and sham-operated animals and are usually thought to be unaffected by experimental protocols in which neurosurgery is performed. However, there is insufficient evidence in the literature on the behaviour...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/4385706
更新日期:2020-03-09 00:00:00
abstract::Anxiety in Parkinson's disease (aPD) is underdiagnosed, undertreated, and understudied. As many as 50% of persons diagnosed with Parkinson's disease (PD) are reported to suffer from anxiety. Current treatment is largely pharmacologic, which can result in a myriad of undesirable and unsafe side effects. The aim of this...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2019/8459579
更新日期:2019-05-02 00:00:00
abstract::Although proverb tests are commonly used in the mental status examination surprisingly little is known about either normal comprehension or the interpretation of proverbial expressions. Current proverbs tests have conceptual and linguistic shortcomings, and few studies have been done to investigate the specific effect...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1990-3304
更新日期:1990-01-01 00:00:00
abstract::Dementia of frontal lobe type may precede motor signs in a number of adult patients with amyotrophy. Neuropathological studies have shown neuron loss, spongiosis and gliosis mainly in layers II and III of the frontal and temporal lobes, together with myelin pallor of the subcortical white matter. Golgi studies reveale...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1992-5204
更新日期:1992-01-01 00:00:00
abstract::Patients with Cushing's syndrome (CS) in remission often suffer from impaired quality of life and cognitive dysfunction. The primary aim was to investigate the occurrence of mental fatigue, characterized by mental exhaustion and long recovery time following mentally strenuous tasks, in patients with CS in remission. T...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/173653
更新日期:2015-01-01 00:00:00
abstract:Background:Medication adherence and belief are crucial to achieving the desired goal of therapy in epileptic patients. However, there is a lack of study regarding medication adherence and belief in our setting. Therefore, the purpose of this study was to investigate medication adherence and belief and associated factor...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2019/2806341
更新日期:2019-04-23 00:00:00