Cerebellar information processing in relapsing-remitting multiple sclerosis (RRMS).

Abstract:

:Recent research has characterized the anatomical connectivity of the cortico-cerebellar system - a large and important fibre system in the primate brain. Within this system, there are reciprocal projections between the prefrontal cortex and Crus II of the cerebellar cortex, which both play important roles in the acquisition and execution of cognitive skills. Here, we propose that this system also plays a particular role in sustaining skilled cognitive performance in patients with Relapsing-Remitting Multiple Sclerosis (RRMS), in whom advancing neuropathology causes increasingly inefficient information processing. We scanned RRMS patients and closely matched healthy subjects while they performed the Paced Auditory Serial Addition Test (PASAT), a demanding test of information processing speed, and a control task. This enabled us to localize differences between conditions that change as a function of group (group-by-condition interactions). Hemodynamic activity in some patient populations with CNS pathology are not well understood and may be atypical, so we avoided analysis strategies that rely exclusively on models of hemodynamic activity derived from the healthy brain, using instead an approach that combined a 'model-free' analysis technique (Tensor Independent Component Analysis, TICA) that was relatively free of such assumptions, with a post-hoc 'model-based' approach (General Linear Model, GLM). Our results showed group-by-condition interactions in cerebellar cortical Crus II. We suggest that this area may have in role maintaining performance in working memory tasks by compensating for inefficient data transfer associated with white matter lesions in MS.

journal_name

Behav Neurol

journal_title

Behavioural neurology

authors

Lesage E,Apps MA,Hayter AL,Beckmann CF,Barnes D,Langdon DW,Ramnani N

doi

10.3233/BEN-2010-0267

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

39-49

issue

1-2

eissn

0953-4180

issn

1875-8584

pii

5046K4K208H88648

journal_volume

23

pub_type

杂志文章
  • The role of dopamine and glutamate modulation in Huntington disease.

    abstract:BACKGROUND:Huntington disease (HD) is an inherited neuropsychiatric condition with progressive neurodegenerative changes, mainly affecting the striatum. Pathological processes within the striatum are likely to lead to alterations in dopamine and glutamate activity in frontostriatal circuitry, resulting in characteristi...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.3233/BEN-2012-120268

    authors: Mittal SK,Eddy C

    更新日期:2013-01-01 00:00:00

  • Gilles de la Tourette syndrome-a case report from Guyana in South America.

    abstract::A case of the Gilles de la Tourette syndrome from Guyana in South America is presented. The patient had a positive family history as well as coprolalia, echolalia, and attention deficit disorder with hyperactivity. The family history and cross-cultural similarity emphasise the biological factors in the aetiology of th...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1992-5107

    authors: Eapen V,Robertson MM

    更新日期:1992-01-01 00:00:00

  • Thalamic lesions: a radiological review.

    abstract:BACKGROUND:Thalamic lesions are seen in a multitude of disorders including vascular diseases, metabolic disorders, inflammatory diseases, trauma, tumours, and infections. In some diseases, thalamic involvement is typical and sometimes isolated, while in other diseases thalamic lesions are observed only occasionally (of...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.1155/2014/154631

    authors: Renard D,Castelnovo G,Campello C,Bouly S,Le Floch A,Thouvenot E,Waconge A,Taieb G

    更新日期:2014-01-01 00:00:00

  • Body concept, disability, and depression in patients with spasmodic torticollis.

    abstract::Eighty-five patients with idiopathic spasmodic torticollis were compared with an equally chronic group of 49 cervical spondylosis sufferers in terms of body concept, depression, and disability. The torticollis patients were significantly more depressed and disabled and had a more negative body concept. Depression had ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1990-3206

    authors: Jahanshahi M,Marsden CD

    更新日期:1990-01-01 00:00:00

  • The Effects of Gender Differences in Patients with Depression on Their Emotional Working Memory and Emotional Experience.

    abstract::A large amount of research has been conducted on the effects of sex hormones on gender differences in patients with depression, yet research on cognitive differences between male and female patients with depression is insufficient. This study uses emotion pictures to investigate the differences of the emotional workin...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2015/807343

    authors: Li M,Lu S,Wang G,Zhong N

    更新日期:2015-01-01 00:00:00

  • Neuroprotective Effect of DAHP via Antiapoptosis in Cerebral Ischemia.

    abstract::Aberrant production of nitric oxide following inducible nitric oxide synthase (iNOS) expression has been implicated in cell death and contributes to ischemic brain injury. Tetrahydrobiopterin (BH4) is an essential cofactor of NOS activity. Herein, we evaluated antiapoptotic and anti-inflammatory effects of diamino-6-h...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2018/5050469

    authors: Qin Y,Hu W,Yang Y,Hu Z,Li W,Fang M

    更新日期:2018-06-19 00:00:00

  • Improving Cognitive Function after Traumatic Brain Injury: A Clinical Trial on the Potential Use of the Semi-Immersive Virtual Reality.

    abstract::Traumatic brain injury (TBI) is the most common cause of long-term disability and death among young adults, and it represents an enormous socioeconomic and healthcare burden. Our purpose is to evaluate the effects of a virtual reality training with BTs-Nirvana (BTs-N) on the recovery of cognitive functions in TBI subj...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2019/9268179

    authors: De Luca R,Maggio MG,Maresca G,Latella D,Cannavò A,Sciarrone F,Lo Voi E,Accorinti M,Bramanti P,Calabrò RS

    更新日期:2019-07-30 00:00:00

  • Aggressive behaviour in Huntington's disease: a cross-sectional study in a nursing home population.

    abstract::We describe a cross-sectional study of aggressive behaviour in a sample of patients suffering from Huntington's disease in a residential nursing home. Data were obtained using the RAGE, a behaviourally oriented rating scale for measuring aggressive behaviour in cognitively impaired patients. Nursing staff rated 27 pat...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1993-6107

    authors: Shiwach RS,Patel V

    更新日期:1993-01-01 00:00:00

  • Mirror-reversal of a face is perceived as expressing emotions more intensely.

    abstract::This study examined hemispatial bias in a free-viewing condition of the judgement of facial expressions of emotions. Right-handed male subjects were asked to judge the intensity, in terms of expressiveness, of facial emotion in normal and mirror-reversed orientations. Expressions in mirror-reversed orientation were pe...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1996-93-402

    authors: Asthana HS,Mandal MK

    更新日期:1996-01-01 00:00:00

  • Clinical application of standardized cognitive assessment using fMRI. I. Matrix reasoning.

    abstract::Functional MRI is increasingly recognized for its potential as a powerful new tool in clinical neuropsychology. This is likely due to the fact that, with some degree of innovation, it is possible to convert practically any familiar cognitive test into one that can be performed in the MRI scanning environment. However,...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-2008-0223

    authors: Allen MD,Fong AK

    更新日期:2008-01-01 00:00:00

  • Trials of pharmacological interventions for Tourette syndrome: a systematic review.

    abstract:INTRODUCTION:Gilles de la Tourette Syndrome (GTS) is a childhood-onset hyperkinetic movement disorder defined by the chronic presence of multiple motor tics and at least one vocal tic and often complicated by co-morbid behavioural problems. The pharmacological treatment of GTS focuses on the modulation of monoaminergic...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.3233/BEN-2012-120269

    authors: Waldon K,Hill J,Termine C,Balottin U,Cavanna AE

    更新日期:2013-01-01 00:00:00

  • Impaired initiation but not execution of contralesional saccades in hemispatial neglect.

    abstract::Patients with unilateral neglect are impaired at making saccades to contralesional targets. Whether this problem arises from a deficit in perception, in planning the saccade or in executing the eye movement or some combination thereof remains unclear. We measured several variables related to the initiation and executi...

    journal_title:Behavioural neurology

    pub_type: 临床试验,杂志文章

    doi:10.1155/2002/253201

    authors: Behrmann M,Ghiselli-Crippa T,Dimatteo I

    更新日期:2001-01-01 00:00:00

  • Right amygdalar and temporofrontal activation during autobiographic, but not during fictitious memory retrieval.

    abstract::What distinguishes the recall of real-life experiences from that of self-created, fictitious emotionally laden information? Both kinds of information belong to the episodic memory system. Autobiographic memories constitute that part of the episodic memory system that is composed of significant life episodes, primarily...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2000/303651

    authors: Markowitsch HJ,Thiel A,Reinkemeier M,Kessler J,Koyuncu A,Heiss WD

    更新日期:2000-01-01 00:00:00

  • Dementia of frontal lobe type and amyotrophy.

    abstract::Dementia of frontal lobe type may precede motor signs in a number of adult patients with amyotrophy. Neuropathological studies have shown neuron loss, spongiosis and gliosis mainly in layers II and III of the frontal and temporal lobes, together with myelin pallor of the subcortical white matter. Golgi studies reveale...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1992-5204

    authors: Ferrer I

    更新日期:1992-01-01 00:00:00

  • Bipolar disorder and multiple sclerosis: a case series.

    abstract:BACKGROUND:The prevalence of psychiatric disturbance for patients with multiple sclerosis (MS) is higher than that observed in other chronic health conditions. We report three cases of MS and bipolar disorder and we discuss the possible etiological hypothesis and treatment options. OBSERVATIONS:All patients fulfilled ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2014/536503

    authors: Sidhom Y,Ben Djebara M,Hizem Y,Abdelkefi I,Kacem I,Gargouri A,Gouider R

    更新日期:2014-01-01 00:00:00

  • The global workspace (GW) theory of consciousness and epilepsy.

    abstract::The global workspace (GW) theory proposes that conscious processing results from coherent neuronal activity between widely distributed brain regions, with fronto-parietal associative cortices as key elements. In this model, transition between conscious and non conscious states are predicted to be caused by abrupt non-...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.3233/BEN-2011-0313

    authors: Bartolomei F,Naccache L

    更新日期:2011-01-01 00:00:00

  • Neurological soft signs in obsessive compulsive disorder: standardised assessment and comparison with schizophrenia.

    abstract::While several studies have detected raised levels of neurological soft signs in patients with obsessive compulsive disorder (OCD), the specificity of these abnormalities remains uncertain. This study used a new standardised measure, the Cambridge Neurological Inventory (CNI), to assess soft signs in 51 subjects with O...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/1999/639045

    authors: Bolton D,Gibb W,Lees A,Raven P,Gray JA,Chen E,Shafran R

    更新日期:1998-01-01 00:00:00

  • Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice.

    abstract:Objectives:To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods:An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH. The hematoma ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2018/6583267

    authors: Yang H,Ni W,Jiang H,Lei Y,Su J,Gu Y,Zhou L

    更新日期:2018-08-12 00:00:00

  • Can tactile neglect occur at an intra-limb level? Vibrotactile reaction times in patients with right hemisphere damage.

    abstract::Visual reaction time (RT) studies on patients with right hemisphere (RH) damage have demonstrated that the attentional imbalance to stimuli occupying left and right positions exists even within the "intact" ipsilesional hemifield. The purpose of the present study was to test whether such patients might also exhibit re...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1994-7204

    authors: Mattingley JB,Bradshaw JL

    更新日期:1994-01-01 00:00:00

  • Prevalence, and intellectual outcome of unilateral focal cortical brain damage as a function of age, sex and aetiology.

    abstract::Neurologists and neuropsychologists are aware that aging men are more at risk than women for brain damage, principally because of the well known male-predominant risk for cardiovascular disease and related cerebrovascular accidents. However, a disproportion in prevalence of brain damage between the sexes in childhood ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2002/634764

    authors: Braun CM,Montour-Proulx I,Daigneault S,Rouleau I,Kuehn S,Piskopos M,Desmarais G,Lussier F,Rainville C

    更新日期:2001-01-01 00:00:00

  • Analysis of HMPAO SPECT scans in head injury using Statistical Parametric Mapping.

    abstract::The paper examines the ability of Statistical Parametric Mapping (SPM) to contribute towards the quantitative analysis of HMPAO SPECT images containing lesions. A validation study is described in which SPECT images were created that contained synthetic lesions and were analysed with SPM. The study established a set of...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2000/681916

    authors: Stamatakis EA,Wilson JT,Wyper DJ

    更新日期:2000-01-01 00:00:00

  • Progressive micrographia shown in horizontal, but not vertical, writing in Parkinson's disease.

    abstract::All published studies on micrographia, a diminution of letter size, examine handwriting in the horizontal direction. Writing horizontally typically requires increased wrist extension as handwriting progresses from left to right. Chinese characters, however, can be written not only horizontally from left to right, but ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/BEN-120285

    authors: Ma HI,Hwang WJ,Chang SH,Wang TY

    更新日期:2013-01-01 00:00:00

  • Late-onset startle syndrome and obsessive compulsive disorder.

    abstract::A case of late onset sporadic startle syndrome in a patient with a right posterior fossa brain tumour is reported. The exaggerated startle response did not respond to treatment with clonazepam. In addition to anxiety and depression, the patient developed obsessive- compulsive symptoms which responded to behavioural th...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/1998/617160

    authors: Gonzalez A,Philpot MP

    更新日期:1998-01-01 00:00:00

  • A case of frontotemporal lobar degeneration with progressive dysarthria.

    abstract::We investigated the evolution of the neurological and neuropsychological characteristics in a right-handed woman who was 53-years-old at the onset and who showed personality changes and behavioral disorders accompanied by progressive dysarthria. She had hypernasality and a slow rate of speech with distorted consonants...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2006/320638

    authors: Ihori N,Araki S,Ishihara K,Kawamura M

    更新日期:2006-01-01 00:00:00

  • Pathological laughter as a symptom of midbrain infarction.

    abstract::Pathological laughter is an uncommon symptom usually caused by bilateral, diffuse cerebral lesions. It has rarely been reported in association with isolated cerebral lesions. Midbrain involvement causing pathological laughter is extremely unusual. We describe three patients who developed pathological laughter after mi...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2004/409248

    authors: Dabby R,Watemberg N,Lampl Y,Eilam A,Rapaport A,Sadeh M

    更新日期:2004-01-01 00:00:00

  • Whakawhiti Kōrero, a Method for the Development of a Cultural Assessment Tool, Te Waka Kuaka, in Māori Traumatic Brain Injury.

    abstract::The importance of tools for the measurement of outcomes and needs in traumatic brain injury is well recognised. The development of tools for these injuries in indigenous communities has been limited despite the well-documented disparity of brain injury. The wairua theory of traumatic brain injury (TBI) in Māori propos...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2015/137402

    authors: Elder H,Kersten P

    更新日期:2015-01-01 00:00:00

  • The neurology of proverbs.

    abstract::Although proverb tests are commonly used in the mental status examination surprisingly little is known about either normal comprehension or the interpretation of proverbial expressions. Current proverbs tests have conceptual and linguistic shortcomings, and few studies have been done to investigate the specific effect...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1990-3304

    authors: Van Lancker D

    更新日期:1990-01-01 00:00:00

  • A Repeated Measures Pilot Comparison of Trajectories of Fluctuating Endogenous Hormones in Young Women with Traumatic Brain Injury, Healthy Controls.

    abstract:Objective:To compare baseline and 72-hour hormone levels in women with traumatic brain injury (TBI) and controls. Setting:Hospital emergency department. Participants:21 women ages 18-35 with TBI and 21 controls. Design:Repeated measures. Main Measures:Serum samples at baseline and 72 hours; immunoassays for estradi...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2019/7694503

    authors: Niemeier JP,Perrin PB,Hurst BS,Foureau DM,Huynh TT,Evans SL,Silverman JE,Elise McClannahan M,Brusch BD,Newman M,Mougeot JL,Wagner AK

    更新日期:2019-02-12 00:00:00

  • Emotional dysfunction in Parkinson's disease.

    abstract::In addition to motor symptomatology, idiopathic Parkinson's disease is characterized by emotional dysfunction. Depression affects some 30 to 40 percent of Parkinson patients and other psychiatric co-morbidities include anxiety and apathy. Neuropsychological and neuroimaging studies of emotional dysfunction in Parkinso...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.3233/BEN-2011-0329

    authors: Blonder LX,Slevin JT

    更新日期:2011-01-01 00:00:00

  • Neuropsychological and Emotional Functioning in Patients with Cushing's Syndrome.

    abstract::Patients with Cushing's syndrome (CS) frequently report impairments in cognitive and emotional functioning. Given neuroimaging research that implicates alterations in structure and function in the brain in this population, goals of this study were to investigate neuropsychological and emotional functioning, with parti...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2020/4064370

    authors: Na S,Fernandes MA,Ioachimescu AG,Penna S

    更新日期:2020-08-07 00:00:00