Abstract:
:Functional MRI is increasingly recognized for its potential as a powerful new tool in clinical neuropsychology. This is likely due to the fact that, with some degree of innovation, it is possible to convert practically any familiar cognitive test into one that can be performed in the MRI scanning environment. However, like any assessment approach, meaningful interpretation of fMRI data for the purpose of patient evaluation crucially requires normative data derived from a sample of unimpaired persons, against which individual patients may be compared. Currently, no such normative data are available for any fMRI-based cognitive testing protocol. In this paper, we report the first of a series of fMRI-compatible cognitive assessment protocols, a matrix reasoning test (f-MRT), for which normative samples of functional activation have been collected from unimpaired control subjects and structured in a manner that makes individual patient evaluation possible in terms of familiar z-score distributions. Practical application of the f-MRT is demonstrated via a contrastive case-study of two individuals with cognitive impairment in which fMRI data identifies subtleties in patient deficits otherwise missed by conventional measures of performance.
journal_name
Behav Neuroljournal_title
Behavioural neurologyauthors
Allen MD,Fong AKdoi
10.3233/BEN-2008-0223subject
Has Abstractpub_date
2008-01-01 00:00:00pages
127-40issue
3eissn
0953-4180issn
1875-8584pii
MK57K826262P8076journal_volume
20pub_type
杂志文章abstract::We report a case of a blind woman, M.N., who experienced the Capgras delusion. She thought that her pet cat had been replaced by a replica which was "ill-intentioned" towards her. M.N.'s case shows that the basis of the Capgras delusion cannot lie exclusively in damage to the visual system. However, testing of M.N.'s ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1993-6409
更新日期:1993-01-01 00:00:00
abstract:Objective:To explore the effects of sevoflurane on the latency and error times of the passive avoidance and levels of PSD-95 and AMPA receptors in the hippocampus. We evaluated the effects of sevoflurane on short-term memory in adult mice and explored the possible mechanism. Methods:144 Kunming mice (2-3 months, 30-35...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2019/1068260
更新日期:2019-10-21 00:00:00
abstract::We investigated the evolution of the neurological and neuropsychological characteristics in a right-handed woman who was 53-years-old at the onset and who showed personality changes and behavioral disorders accompanied by progressive dysarthria. She had hypernasality and a slow rate of speech with distorted consonants...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2006/320638
更新日期:2006-01-01 00:00:00
abstract::Individuals with multiple sclerosis (MS), especially those living in Latin America, often require assistance from family caregivers throughout the duration of the disease. Previous research suggests that family caregivers may experience positive and negative outcomes from providing care to individuals with MS, but few...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/8929735
更新日期:2018-01-17 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) with dementia (ALS-D) is known to exhibit characteristics of frontotemporal dementia. However, in clinical situations, it is often difficult to evaluate their cognitive functions because of impaired voluntary speech and physical disabilities. In order to identify characteristic and ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2008/814846
更新日期:2008-01-01 00:00:00
abstract::Our purpose in undertaking the present study was to examine the hypotheses proposed for explaining the frequent comorbidity of bipolar disorder and multiple sclerosis. One hypothesis posits that, when there is comorbidity, MS plays a causal role in psychiatric manifestations. Another suggests that both disorders have ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2012-110198
更新日期:2012-01-01 00:00:00
abstract::We report findings from a cognitive neuropsychological and psychophysiological investigation of a patient who displayed an exacerbated acute emotional expression during movement, innocuous, and aversive somatosensory stimulation. The condition developed in the context of non-specific white matter ischaemia along with ...
journal_title:Behavioural neurology
pub_type: 临床试验,杂志文章
doi:10.1155/2004/458327
更新日期:2004-01-01 00:00:00
abstract::Since the Korean language has two distinct writing systems, phonogram (Hangul) and ideogram (Hanja: Chinese characters), alexia can present with dissociative disturbances in reading between the two systems. A 74-year-old right-handed man presented with a prominent reading impairment in Hangul with agraphia of both Han...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2008-0211
更新日期:2008-01-01 00:00:00
abstract::The paper examines the ability of Statistical Parametric Mapping (SPM) to contribute towards the quantitative analysis of HMPAO SPECT images containing lesions. A validation study is described in which SPECT images were created that contained synthetic lesions and were analysed with SPM. The study established a set of...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2000/681916
更新日期:2000-01-01 00:00:00
abstract::Dementia with Lewy bodies (DLB) is the second most common degenerative dementia of the central nervous system. The technique 18F-fluorodeoxyglucose positron emission tomography (18F FDG PET) was used to investigate brain metabolism patterns in DLB patients. Conventional statistical methods did not consider intern meta...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/8420658
更新日期:2018-05-08 00:00:00
abstract::The present study is aimed at identifying the most prominent determinants of OCD along with their strength to classify the OCD patients from healthy controls. The data for this cross-sectional study were collected from 200 diagnosed OCD patients and 400 healthy controls. The respondents were selected through purposive...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/2678718
更新日期:2020-06-22 00:00:00
abstract::The aim of the present paper was to investigate the fundamental ethical issues of Deep Brain Stimulation (DBS) on patients remaining in Persistent Vegetative State (PVS). First, the purpose of this analysis was to discuss the nature of this intervention in order to classify it such as an ordinary clinical practice, or...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2014/641213
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The extent of brain damage in chronic stroke patients is traditionally defined as the necrotic tissue observed on magnetic resonance image (MRI). However, patients often exhibit symptoms suggesting that functional impairment may affect areas beyond the cortical necrotic lesion, for example, when cortical sym...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/215380
更新日期:2014-01-01 00:00:00
abstract::The serum concentration achieved and maintained following the administration of a fixed drug dosage is a direct consequence of the interactions of a wide variety of interrelated processes, including drug absorption, distribution, metabolism, and excretion, and the physiological status of the patient. These interrelati...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1990-31S102
更新日期:1990-01-01 00:00:00
abstract::We report a right-handed man who developed selective Kana (phonogram) agraphia following an infarct in the non-dominant right cerebral hemisphere. His ability for comprehension, reading and writing of Kanji (ideogram) was unaffected. Kana errors consisted of substitution with another letter and the number of target wo...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1995-8208
更新日期:1995-01-01 00:00:00
abstract::Neurologists and neuropsychologists are aware that aging men are more at risk than women for brain damage, principally because of the well known male-predominant risk for cardiovascular disease and related cerebrovascular accidents. However, a disproportion in prevalence of brain damage between the sexes in childhood ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2002/634764
更新日期:2001-01-01 00:00:00
abstract::The importance of tools for the measurement of outcomes and needs in traumatic brain injury is well recognised. The development of tools for these injuries in indigenous communities has been limited despite the well-documented disparity of brain injury. The wairua theory of traumatic brain injury (TBI) in Māori propos...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/137402
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To study risk factors related to ischemic stroke (IS) in youth and the influence of sleep quality on youth ischemic stroke incidence. METHODS:223 patients aged 18 to 45 years who were admitted to Puyang People's Hospital from June 2011 to February 2013 with a first-ever ischemic stroke were selected as the r...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/246841
更新日期:2014-01-01 00:00:00
abstract::Gaining a driver's licence represents increased independence and can lead to improved quality of life for individuals and their families. Learning to drive a motor vehicle and maintaining safe on-road skills are often more difficult for people on the autism spectrum. Many countries currently have no autism-specific li...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2018/6842306
更新日期:2018-08-28 00:00:00
abstract::Dementia of frontal lobe type may precede motor signs in a number of adult patients with amyotrophy. Neuropathological studies have shown neuron loss, spongiosis and gliosis mainly in layers II and III of the frontal and temporal lobes, together with myelin pallor of the subcortical white matter. Golgi studies reveale...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1992-5204
更新日期:1992-01-01 00:00:00
abstract:Background:Epilepsy is a chronic neurological disorder characterized by unprovoked recurrent seizure episodes. The disease has detrimental effects on social, cognitive, psychological, and physical components of life consequently quality of life of the patients. The level of the effect of the disease on quality life is ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/7593573
更新日期:2018-12-02 00:00:00
abstract::Patients with unilateral neglect are impaired at making saccades to contralesional targets. Whether this problem arises from a deficit in perception, in planning the saccade or in executing the eye movement or some combination thereof remains unclear. We measured several variables related to the initiation and executi...
journal_title:Behavioural neurology
pub_type: 临床试验,杂志文章
doi:10.1155/2002/253201
更新日期:2001-01-01 00:00:00
abstract::Cannabinoids have been used for hundred of years for medical purposes. To day, the cannabinoid delta-9-tetrahydrocannabinol (THC) and the cannabis extract nabiximols are approved for the treatment of nausea, anorexia and spasticity, respectively. In Tourette syndrome (TS) several anecdotal reports provided evidence th...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-120276
更新日期:2013-01-01 00:00:00
abstract::Cognitive impairment is frequently encountered in multiple sclerosis (MS) affecting between 40-65% of individuals, irrespective of disease duration and severity of physical disability. In the present multicenter randomized controlled trial, fifty-eight clinically stable RRMS patients with mild to moderate cognitive im...
journal_title:Behavioural neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1155/2017/5919841
更新日期:2017-01-01 00:00:00
abstract:Objectives:To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods:An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH. The hematoma ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/6583267
更新日期:2018-08-12 00:00:00
abstract:OBJECTIVE:The purpose of this study was to analyze the effect of a neuropsychological rehabilitation (NR) program on patients with Alzheimer's disease (AD). METHODS:The sample was composed of 16 elderly outpatients who participated in an open trial with rivastigmine (6 to 12 mg/day) for 4 months and were randomized to...
journal_title:Behavioural neurology
pub_type: 杂志文章,随机对照试验
doi:10.1155/2007/915816
更新日期:2007-01-01 00:00:00
abstract::Anxiety in Parkinson's disease (aPD) is underdiagnosed, undertreated, and understudied. As many as 50% of persons diagnosed with Parkinson's disease (PD) are reported to suffer from anxiety. Current treatment is largely pharmacologic, which can result in a myriad of undesirable and unsafe side effects. The aim of this...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2019/8459579
更新日期:2019-05-02 00:00:00
abstract::Neuropsychological studies of memory disorders have played a prominent role in the development of theories of memory. To test and refine such theories in future, it will be advantageous to include research that utilizes physiological measures of the neural events responsible for memory. Measures of the electrical acti...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2000/865250
更新日期:2000-01-01 00:00:00
abstract::The case is reported of a patient (PS) who, following acute encephalitis with residual occipito-temporal damage, showed a selective deficit in writing cursive letters in isolation, but no difficulty to write cursive-case words and non-words. Notably, he was able to recognize the same allographs he could not write and ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2012-119008
更新日期:2012-01-01 00:00:00
abstract::Primary sexual dysfunctions (SD) are a direct result of neurological changes that affect the sexual response. Secondary SD result from the symptoms that do not directly involve nervous pathways to the genital system, such as bladder and bowel problems, fatigue, spasticity, or muscle weakness. Tertiary SD are the resul...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/8857516
更新日期:2020-10-10 00:00:00