Abstract:
Objectives:To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods:An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH. The hematoma volume and hemoglobin level were measured to examine hematoma resolution. A behavior test and brain edema and white matter injury examinations indicated brain injury after ICH. Results:Scriptaid treatment promoted hematoma resolution and reduced the hematoma volume 7 d after ICH compared with the vehicle group (P < 0.05). Scriptaid treatment also alleviated the brain water content in the ipsilateral basal ganglia (P < 0.05) and cortex (P < 0.01) 3 d after ICH. In addition, Scriptaid improved neurological function recovery and alleviated white matter injury 35 d after ICH. Conclusions:Scriptaid can protect against brain injury after ICH and may be considered a new medical therapy method for ICH.
journal_name
Behav Neuroljournal_title
Behavioural neurologyauthors
Yang H,Ni W,Jiang H,Lei Y,Su J,Gu Y,Zhou Ldoi
10.1155/2018/6583267subject
Has Abstractpub_date
2018-08-12 00:00:00pages
6583267eissn
0953-4180issn
1875-8584journal_volume
2018pub_type
杂志文章abstract::Amyotrophic lateral sclerosis (ALS) with dementia (ALS-D) is known to exhibit characteristics of frontotemporal dementia. However, in clinical situations, it is often difficult to evaluate their cognitive functions because of impaired voluntary speech and physical disabilities. In order to identify characteristic and ...
journal_title:Behavioural neurology
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pub_type: 临床试验,杂志文章
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journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1996-93-402
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journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1996-9203
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pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00