Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice.

Abstract:

Objectives:To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods:An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH. The hematoma volume and hemoglobin level were measured to examine hematoma resolution. A behavior test and brain edema and white matter injury examinations indicated brain injury after ICH. Results:Scriptaid treatment promoted hematoma resolution and reduced the hematoma volume 7 d after ICH compared with the vehicle group (P < 0.05). Scriptaid treatment also alleviated the brain water content in the ipsilateral basal ganglia (P < 0.05) and cortex (P < 0.01) 3 d after ICH. In addition, Scriptaid improved neurological function recovery and alleviated white matter injury 35 d after ICH. Conclusions:Scriptaid can protect against brain injury after ICH and may be considered a new medical therapy method for ICH.

journal_name

Behav Neurol

journal_title

Behavioural neurology

authors

Yang H,Ni W,Jiang H,Lei Y,Su J,Gu Y,Zhou L

doi

10.1155/2018/6583267

subject

Has Abstract

pub_date

2018-08-12 00:00:00

pages

6583267

eissn

0953-4180

issn

1875-8584

journal_volume

2018

pub_type

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