Abstract:
:The serum concentration achieved and maintained following the administration of a fixed drug dosage is a direct consequence of the interactions of a wide variety of interrelated processes, including drug absorption, distribution, metabolism, and excretion, and the physiological status of the patient. These interrelationships are reviewed with specific reference to the major anti-epileptic drugs, phenobarbitone, phenytoin, sodium valproate, and carbamazepine, as well as a new first-line antiepileptic, oxcarbazepine.Both older drugs, such as phenobarbitone and phenytoin, and newer drugs, such as carbamazepine (CBZ) and sodium valproate, have been studied extensively over the past years giving valuable information for drug treatment. An important feature of oxcarbazepine (OXC) , which was developed through minimal changes in the structure of CBZ in order to improve on the tolerability of CBZ without sacrificing efficacy, is that its metabolites do not include the 11-epoxide which has been implicated in the side-effects of CBZ. In man, OXC is metabolized to a monohydroxy derivative which has independent anti-epileptic properties. OXC seems to lack several disadavantageous pharmacokinetic properties common to other major anti-epileptic drugs. OXC does not influence its own metabolism after repeated administration, in contrast to the auto-induction displayed by CBZ. The metabolism of OXC is not influenced by anti-epileptic co-medication and does not influence the kinetics of other anti-epileptic drugs - or if it does, then to a lesser extent than CBZ.
journal_name
Behav Neuroljournal_title
Behavioural neurologyauthors
Johannessen SIdoi
10.3233/BEN-1990-31S102subject
Has Abstractpub_date
1990-01-01 00:00:00pages
1-11issue
1eissn
0953-4180issn
1875-8584pii
0434P153G10450X2journal_volume
3pub_type
杂志文章abstract::This report presents a syndrome resembling obsessive convulsive disorder (OCD) secondary to a stroke in the left basal ganglia. The patient's syndrome is virtually identical to those that have been described in bilateral damage of the basal ganglia. However, the stroke described in this case report is located unilater...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1997-102-308
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Little is known about physical activity and its association with volumes of whole brain gray matter and white matter and deep gray matter structures in persons with multiple sclerosis (MS). PURPOSE:This study examined the association between levels of physical activity and brain volumetric measures from mag...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/482536
更新日期:2015-01-01 00:00:00
abstract::The jugular venous pulse (JVP) provides valuable information about cardiac haemodynamics and filling pressures and is an indirect estimate of the central venous pressure (CVP). Recently it has been proven that JVP can be obtained by measuring the cross-sectional area (CSA) of the IJV on each sonogram of an ultrasound ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/170756
更新日期:2015-01-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) with dementia (ALS-D) is known to exhibit characteristics of frontotemporal dementia. However, in clinical situations, it is often difficult to evaluate their cognitive functions because of impaired voluntary speech and physical disabilities. In order to identify characteristic and ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2008/814846
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Increasing proportion of the elderly in the driving population raises the importance of assuring their safety. We explored the effects of three different types of cognitive training on the cognitive function, brain structure, and driving safety of the elderly. METHODS:Thirty-seven healthy elderly daily driv...
journal_title:Behavioural neurology
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/525901
更新日期:2015-01-01 00:00:00
abstract::Current research supports the strong potential of structural MRI profiles, even within cross-sectional designs, as a promising method for the discrimination of Alzheimer's Disease (AD) from normal controls and for the prediction of Mild Cognitive Impairment (MCI) progression and conversion to AD. Findings suggest that...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-2009-0230
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Thalamic lesions are seen in a multitude of disorders including vascular diseases, metabolic disorders, inflammatory diseases, trauma, tumours, and infections. In some diseases, thalamic involvement is typical and sometimes isolated, while in other diseases thalamic lesions are observed only occasionally (of...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2014/154631
更新日期:2014-01-01 00:00:00
abstract:Objective:To compare baseline and 72-hour hormone levels in women with traumatic brain injury (TBI) and controls. Setting:Hospital emergency department. Participants:21 women ages 18-35 with TBI and 21 controls. Design:Repeated measures. Main Measures:Serum samples at baseline and 72 hours; immunoassays for estradi...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2019/7694503
更新日期:2019-02-12 00:00:00
abstract:Objectives:To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods:An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH. The hematoma ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/6583267
更新日期:2018-08-12 00:00:00
abstract:BACKGROUND:Tacrolimus-associated encephalopathy (TAC-E) is usually described under the term of posterior reversible encephalopathy syndrome (PRES). However, a large amount of data has suggested that TAC-E is not a homogenous entity: indeed, TAC-E which is often presented with atypical and potentially misleading imaging...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/931808
更新日期:2014-01-01 00:00:00
abstract::Cannabinoids have been used for hundred of years for medical purposes. To day, the cannabinoid delta-9-tetrahydrocannabinol (THC) and the cannabis extract nabiximols are approved for the treatment of nausea, anorexia and spasticity, respectively. In Tourette syndrome (TS) several anecdotal reports provided evidence th...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-120276
更新日期:2013-01-01 00:00:00
abstract::We report a case of a blind woman, M.N., who experienced the Capgras delusion. She thought that her pet cat had been replaced by a replica which was "ill-intentioned" towards her. M.N.'s case shows that the basis of the Capgras delusion cannot lie exclusively in damage to the visual system. However, testing of M.N.'s ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1993-6409
更新日期:1993-01-01 00:00:00
abstract::Aiming and tapping movements were analysed repeatedly over a three-week period in a patient who was hemideafferented due to an ischaemic posterior thalamic lesion. Contrasting behaviour observed in six healthy subjects, nine hemiparetic patients and one patient with hemianopic stroke, allowed the determination of beha...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1997-10103
更新日期:1997-01-01 00:00:00
abstract::The case is reported of a patient (PS) who, following acute encephalitis with residual occipito-temporal damage, showed a selective deficit in writing cursive letters in isolation, but no difficulty to write cursive-case words and non-words. Notably, he was able to recognize the same allographs he could not write and ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2012-119008
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to analyze the effect of a neuropsychological rehabilitation (NR) program on patients with Alzheimer's disease (AD). METHODS:The sample was composed of 16 elderly outpatients who participated in an open trial with rivastigmine (6 to 12 mg/day) for 4 months and were randomized to...
journal_title:Behavioural neurology
pub_type: 杂志文章,随机对照试验
doi:10.1155/2007/915816
更新日期:2007-01-01 00:00:00
abstract::Patients with brain function disorders due to stroke or dementia may show inability to recognize themselves in the mirror. Although the cognitive ability to recognize mirror images has been investigated in many animal species, the animal species that can be used for experimentation and the mechanisms involved in recog...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/4071315
更新日期:2020-02-03 00:00:00
abstract:Background:Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) share many risk factors. Evidence suggests that metabolic risk factors are important to AD; however, their association with DLB is unclear. The risk of cardiovascular diseases (CVD) associated with AD and DLB is also uncertain. Thus, this nationwid...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/8312346
更新日期:2018-06-03 00:00:00
abstract::Psychogenic amnesia is a complex disorder characterised by a wide variety of symptoms. Consequently, in a number of cases it is difficult distinguish it from organic memory impairment. The present study reports a new case of global psychogenic amnesia compared with two patients with amnesia underlain by organic brain ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2007/193140
更新日期:2007-01-01 00:00:00
abstract::Patients with Cushing's syndrome (CS) in remission often suffer from impaired quality of life and cognitive dysfunction. The primary aim was to investigate the occurrence of mental fatigue, characterized by mental exhaustion and long recovery time following mentally strenuous tasks, in patients with CS in remission. T...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/173653
更新日期:2015-01-01 00:00:00
abstract::The aim of the present paper was to investigate the fundamental ethical issues of Deep Brain Stimulation (DBS) on patients remaining in Persistent Vegetative State (PVS). First, the purpose of this analysis was to discuss the nature of this intervention in order to classify it such as an ordinary clinical practice, or...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2014/641213
更新日期:2014-01-01 00:00:00
abstract::We investigated completion phenomenon for proverbs in cases demonstrating transcortical sensory aphasia due to a variety of diseases. Lack of this completion was exclusively observed in patients with focal atrophy. These patients showed a selective and consistent impairment in word comprehension without phonemic cue e...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1993-6304
更新日期:1993-01-01 00:00:00
abstract::We describe a cross-sectional study of aggressive behaviour in a sample of patients suffering from Huntington's disease in a residential nursing home. Data were obtained using the RAGE, a behaviourally oriented rating scale for measuring aggressive behaviour in cognitively impaired patients. Nursing staff rated 27 pat...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1993-6107
更新日期:1993-01-01 00:00:00
abstract::A large amount of research has been conducted on the effects of sex hormones on gender differences in patients with depression, yet research on cognitive differences between male and female patients with depression is insufficient. This study uses emotion pictures to investigate the differences of the emotional workin...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/807343
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Gilles de la Tourette Syndrome (GTS) is a childhood-onset hyperkinetic movement disorder defined by the chronic presence of multiple motor tics and at least one vocal tic and often complicated by co-morbid behavioural problems. The pharmacological treatment of GTS focuses on the modulation of monoaminergic...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-2012-120269
更新日期:2013-01-01 00:00:00
abstract::Two experiments examined short-term memory for order information in six patients diagnosed with Parkinson's disease (PD) and six control subjects while event related potentials (ERPs) were recorded. The subjects were tested for recognition of abstract spatial designs and words after a 5 s retention interval. The PD pa...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1996-9203
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Apathy and reduced emotion-based decision-making are two behavioral modifications independently described in Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). OBJECTIVES:The aims of this study were to investigate decision-making based on emotional feedback processing in AD and aMCI and...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/231469
更新日期:2014-01-01 00:00:00
abstract::Traumatic brain injury (TBI) is the most common cause of long-term disability and death among young adults, and it represents an enormous socioeconomic and healthcare burden. Our purpose is to evaluate the effects of a virtual reality training with BTs-Nirvana (BTs-N) on the recovery of cognitive functions in TBI subj...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2019/9268179
更新日期:2019-07-30 00:00:00
abstract::Primary sexual dysfunctions (SD) are a direct result of neurological changes that affect the sexual response. Secondary SD result from the symptoms that do not directly involve nervous pathways to the genital system, such as bladder and bowel problems, fatigue, spasticity, or muscle weakness. Tertiary SD are the resul...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/8857516
更新日期:2020-10-10 00:00:00
abstract::A case of late onset sporadic startle syndrome in a patient with a right posterior fossa brain tumour is reported. The exaggerated startle response did not respond to treatment with clonazepam. In addition to anxiety and depression, the patient developed obsessive- compulsive symptoms which responded to behavioural th...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/1998/617160
更新日期:1998-01-01 00:00:00
abstract::Although proverb tests are commonly used in the mental status examination surprisingly little is known about either normal comprehension or the interpretation of proverbial expressions. Current proverbs tests have conceptual and linguistic shortcomings, and few studies have been done to investigate the specific effect...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1990-3304
更新日期:1990-01-01 00:00:00