Abstract:
Background:Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) share many risk factors. Evidence suggests that metabolic risk factors are important to AD; however, their association with DLB is unclear. The risk of cardiovascular diseases (CVD) associated with AD and DLB is also uncertain. Thus, this nationwide, population-based study was designed to evaluate the metabolic and CVD risks in AD and DLB. Materials and Methods:Data were obtained from the Taiwan National Health Insurance Research Database. AD patients, DLB patients, and normal control (NC) individuals from 1996 to 2013 were enrolled for risk assessment. Results:In total, 7544 NC individuals, 1324 AD patients, and 562 DLB patients were enrolled. Participants with one or more metabolic risk factors had significantly higher odds of AD or DLB. No significant differences in metabolic risk factors were observed between DLB and AD patients. AD patients had a lower risk of CVD (aHR = 0.67, 95% CI = 0.59-0.76, p value < 0.001) and coronary artery disease (CAD) (aHR = 0.59, 95% CI = 0.51-0.69, p value < 0.001) than NC. DLB patients had a higher risk of ischemic stroke (aHR = 2.27, 95% CI = 1.68-3.06, p value < 0.001) than NC. Conclusion:Metabolic risk factors are important in AD and DLB. Patients with AD might have a lower risk of CAD and ischemic strokes. Patients with DLB might have a higher risk of ischemic stroke.
journal_name
Behav Neuroljournal_title
Behavioural neurologyauthors
Cheng CK,Tsao YC,Su YC,Sung FC,Tai HC,Kung WMdoi
10.1155/2018/8312346subject
Has Abstractpub_date
2018-06-03 00:00:00pages
8312346eissn
0953-4180issn
1875-8584journal_volume
2018pub_type
杂志文章abstract::When assessing for the presence of hemianesthesia, the examiner touches the body of the patients, and requests that they report verbally the location of the delivered tactile stimulus. Contralesional omissions of single tactile stimuli, however, might be due to either primary somatosensory deficits or to spatial atten...
journal_title:Behavioural neurology
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Behavioural neurology
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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