Abstract:
BACKGROUND:Little is known about physical activity and its association with volumes of whole brain gray matter and white matter and deep gray matter structures in persons with multiple sclerosis (MS). PURPOSE:This study examined the association between levels of physical activity and brain volumetric measures from magnetic resonance imaging (MRI) in MS. METHOD:39 persons with MS wore an accelerometer for a 7-day period and underwent a brain MRI. Normalized GM volume (NGMV), normalized WM volume (NWMV), and deep GM structures were calculated from 3D T1-weighted structural brain images. We conducted partial correlations (pr) controlling for demographic and clinical variables. RESULTS:Moderate-to-vigorous physical activity (MVPA) was significantly associated with NGMV (pr = 0.370, p < 0.05), NWMV (pr = 0.433, p < 0.01), hippocampus (pr = 0.499, p < 0.01), thalamus (pr = 0.380, p < 0.05), caudate (pr = 0.539, p < 0.01), putamen (pr = 0.369, p < 0.05), and pallidum (pr = 0.498, p < 0.01) volumes, when controlling for sex, age, clinical course of MS, and Expanded Disability Status Scale score. There were no associations between sedentary and light physical activity with MRI outcomes. CONCLUSION:Our results provide the first evidence that MVPA is associated with volumes of whole brain GM and WM and deep GM structures that are involved in motor and cognitive functions in MS.
journal_name
Behav Neuroljournal_title
Behavioural neurologyauthors
Klaren RE,Hubbard EA,Motl RW,Pilutti LA,Wetter NC,Sutton BPdoi
10.1155/2015/482536subject
Has Abstractpub_date
2015-01-01 00:00:00pages
482536eissn
0953-4180issn
1875-8584journal_volume
2015pub_type
杂志文章abstract:BACKGROUND:The prevalence of psychiatric disturbance for patients with multiple sclerosis (MS) is higher than that observed in other chronic health conditions. We report three cases of MS and bipolar disorder and we discuss the possible etiological hypothesis and treatment options. OBSERVATIONS:All patients fulfilled ...
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