Trials of pharmacological interventions for Tourette syndrome: a systematic review.

Abstract:

INTRODUCTION:Gilles de la Tourette Syndrome (GTS) is a childhood-onset hyperkinetic movement disorder defined by the chronic presence of multiple motor tics and at least one vocal tic and often complicated by co-morbid behavioural problems. The pharmacological treatment of GTS focuses on the modulation of monoaminergic pathways within the cortico-striato-thalamo-cortical circuitry. This paper aims to evaluate the efficacy and safety profiles of pharmacological agents used in the treatment of tics in patients with GTS, in order to provide clinicians with an evidence-based rationale for the pharmacological treatment in GTS. METHOD:In order to ascertain the best level of evidence, we conducted a systematic literature review to identify double-blind randomised controlled trials of medications in GTS populations. RESULTS:We identified a large number of pharmacological agents as potentially effective in improving tic symptoms. The alpha-2 agonist Clonidine is amongst the agents with the most favourable efficacy-versus-adverse events ratio, especially in patients with co-morbid attention-deficit hyperactivity disorder, although effect sizes vary evidence-based studies. DISCUSSION:Our results are in line with the findings of uncontrolled open-label studies. However, most trials have low statistical power due to the small sample sizes, and newer agents, such as Aripiprazole, have not been formally tested in double-blind randomised controlled trials. Further research should focus on better outcome measures, including Quality of Life instruments.

journal_name

Behav Neurol

journal_title

Behavioural neurology

authors

Waldon K,Hill J,Termine C,Balottin U,Cavanna AE

doi

10.3233/BEN-2012-120269

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

265-73

issue

4

eissn

0953-4180

issn

1875-8584

pii

05287001UT3J6260

journal_volume

26

pub_type

杂志文章,评审
  • Gilles de la Tourette syndrome-a case report from Guyana in South America.

    abstract::A case of the Gilles de la Tourette syndrome from Guyana in South America is presented. The patient had a positive family history as well as coprolalia, echolalia, and attention deficit disorder with hyperactivity. The family history and cross-cultural similarity emphasise the biological factors in the aetiology of th...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1992-5107

    authors: Eapen V,Robertson MM

    更新日期:1992-01-01 00:00:00

  • Heterogeneity of radiological spectrum in tacrolimus-associated encephalopathy after lung transplantation.

    abstract:BACKGROUND:Tacrolimus-associated encephalopathy (TAC-E) is usually described under the term of posterior reversible encephalopathy syndrome (PRES). However, a large amount of data has suggested that TAC-E is not a homogenous entity: indeed, TAC-E which is often presented with atypical and potentially misleading imaging...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2014/931808

    authors: Wu Q,Marescaux C,Qin X,Kessler R,Yang J

    更新日期:2014-01-01 00:00:00

  • Event related potentials and serial list picture memory in Parkinson's patients.

    abstract::Two experiments examined short-term memory for order information in six patients diagnosed with Parkinson's disease (PD) and six control subjects while event related potentials (ERPs) were recorded. The subjects were tested for recognition of abstract spatial designs and words after a 5 s retention interval. The PD pa...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1996-9203

    authors: Korsnes MS,Reinvang I

    更新日期:1996-01-01 00:00:00

  • Biomarkers of Eating Disorders Using Support Vector Machine Analysis of Structural Neuroimaging Data: Preliminary Results.

    abstract::Presently, there are no valid biomarkers to identify individuals with eating disorders (ED). The aim of this work was to assess the feasibility of a machine learning method for extracting reliable neuroimaging features allowing individual categorization of patients with ED. Support Vector Machine (SVM) technique, comb...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2015/924814

    authors: Cerasa A,Castiglioni I,Salvatore C,Funaro A,Martino I,Alfano S,Donzuso G,Perrotta P,Gioia MC,Gilardi MC,Quattrone A

    更新日期:2015-01-01 00:00:00

  • Familial comorbidity of bipolar disorder and multiple sclerosis: genetic susceptibility, coexistence or causal relationship?

    abstract::Our purpose in undertaking the present study was to examine the hypotheses proposed for explaining the frequent comorbidity of bipolar disorder and multiple sclerosis. One hypothesis posits that, when there is comorbidity, MS plays a causal role in psychiatric manifestations. Another suggests that both disorders have ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-2012-110198

    authors: Kosmidis MH,Bozikas VP,Giannouli V,Karavatos A,Fokas K

    更新日期:2012-01-01 00:00:00

  • Neuropsychological and Emotional Functioning in Patients with Cushing's Syndrome.

    abstract::Patients with Cushing's syndrome (CS) frequently report impairments in cognitive and emotional functioning. Given neuroimaging research that implicates alterations in structure and function in the brain in this population, goals of this study were to investigate neuropsychological and emotional functioning, with parti...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2020/4064370

    authors: Na S,Fernandes MA,Ioachimescu AG,Penna S

    更新日期:2020-08-07 00:00:00

  • Whakawhiti Kōrero, a Method for the Development of a Cultural Assessment Tool, Te Waka Kuaka, in Māori Traumatic Brain Injury.

    abstract::The importance of tools for the measurement of outcomes and needs in traumatic brain injury is well recognised. The development of tools for these injuries in indigenous communities has been limited despite the well-documented disparity of brain injury. The wairua theory of traumatic brain injury (TBI) in Māori propos...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2015/137402

    authors: Elder H,Kersten P

    更新日期:2015-01-01 00:00:00

  • Progressive micrographia shown in horizontal, but not vertical, writing in Parkinson's disease.

    abstract::All published studies on micrographia, a diminution of letter size, examine handwriting in the horizontal direction. Writing horizontally typically requires increased wrist extension as handwriting progresses from left to right. Chinese characters, however, can be written not only horizontally from left to right, but ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/BEN-120285

    authors: Ma HI,Hwang WJ,Chang SH,Wang TY

    更新日期:2013-01-01 00:00:00

  • Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice.

    abstract:Objectives:To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods:An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH. The hematoma ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2018/6583267

    authors: Yang H,Ni W,Jiang H,Lei Y,Su J,Gu Y,Zhou L

    更新日期:2018-08-12 00:00:00

  • The global workspace (GW) theory of consciousness and epilepsy.

    abstract::The global workspace (GW) theory proposes that conscious processing results from coherent neuronal activity between widely distributed brain regions, with fronto-parietal associative cortices as key elements. In this model, transition between conscious and non conscious states are predicted to be caused by abrupt non-...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.3233/BEN-2011-0313

    authors: Bartolomei F,Naccache L

    更新日期:2011-01-01 00:00:00

  • Letter form as a constraint for errors in neglect dyslexia and letter position dyslexia.

    abstract::Does letter-form constrain errors in peripheral dyslexia? In Hebrew, 5 of the 22 letters have two different letter forms, one is used only when the letter occurs in word-final position, the other form is used in initial and middle positions. Is the information on final-forms encoded in the letter identity information ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2005/635634

    authors: Friedmann N,Gvion A

    更新日期:2005-01-01 00:00:00

  • Allographic agraphia for single letters.

    abstract::The case is reported of a patient (PS) who, following acute encephalitis with residual occipito-temporal damage, showed a selective deficit in writing cursive letters in isolation, but no difficulty to write cursive-case words and non-words. Notably, he was able to recognize the same allographs he could not write and ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-2012-119008

    authors: Menichelli A,Machetta F,Zadini A,Semenza C

    更新日期:2012-01-01 00:00:00

  • Mediational Model of Multiple Sclerosis Impairments, Family Needs, and Caregiver Mental Health in Guadalajara, Mexico.

    abstract::Individuals with multiple sclerosis (MS), especially those living in Latin America, often require assistance from family caregivers throughout the duration of the disease. Previous research suggests that family caregivers may experience positive and negative outcomes from providing care to individuals with MS, but few...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2018/8929735

    authors: Mickens MN,Perrin PB,Aguayo A,Rabago B,Macías-Islas MA,Arango-Lasprilla JC

    更新日期:2018-01-17 00:00:00

  • Different views about the nature of gender-related asymmetries in tasks based on biological or artefact categories.

    abstract::Sex-related asymmetries in the ability to process different semantic categories have been reported both in normal subjects and in brain-damaged patients, but the nature of these asymmetries is still controversial. Some authors suggest that these differences might be due to social-role related familiarity factors, wher...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/ben-2009-0247

    authors: Gainotti G,Ciaraffa F,Silveri MC,Marra C

    更新日期:2010-01-01 00:00:00

  • Functional Connectivity Changes in Behavioral, Semantic, and Nonfluent Variants of Frontotemporal Dementia.

    abstract::Frontotemporal dementia (FTD) affects behavior, language, and personality. This study aims to explore functional connectivity changes in three FTD variants: behavioral (bvFTD), semantic (svPPA), and nonfluent variant (nfvPPA). Seventy-six patients diagnosed with FTD by international criteria and thirty-two controls we...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2018/9684129

    authors: Reyes P,Ortega-Merchan MP,Rueda A,Uriza F,Santamaria-García H,Rojas-Serrano N,Rodriguez-Santos J,Velasco-Leon MC,Rodriguez-Parra JD,Mora-Diaz DE,Matallana D

    更新日期:2018-04-01 00:00:00

  • Type a behaviours and heart disease: epidemiological and experimental foundations.

    abstract::This paper critically examines three strands of evidence that concern the relationship between type A behaviours and coronary heart disease; prospective epidemiological studies of healthy populations, studies of those at high risk for coronary heart disease, and angiographic studies of atherosclerosis. The first of th...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1990-3405

    authors: Bennett P,Carroll D

    更新日期:1990-01-01 00:00:00

  • How to differentiate hemianesthesia from left tactile neglect: a preliminary case report.

    abstract::When assessing for the presence of hemianesthesia, the examiner touches the body of the patients, and requests that they report verbally the location of the delivered tactile stimulus. Contralesional omissions of single tactile stimuli, however, might be due to either primary somatosensory deficits or to spatial atten...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-2012-110225

    authors: Pitteri M,Venneri A,Meneghello F,Priftis K

    更新日期:2013-01-01 00:00:00

  • Pharmacokinetics of Anti-epileptic Drugs and their Clinical Significance.

    abstract::The serum concentration achieved and maintained following the administration of a fixed drug dosage is a direct consequence of the interactions of a wide variety of interrelated processes, including drug absorption, distribution, metabolism, and excretion, and the physiological status of the patient. These interrelati...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1990-31S102

    authors: Johannessen SI

    更新日期:1990-01-01 00:00:00

  • Parkinsonian patients with deficits in the dysexecutive spectrum are impaired on theory of mind tasks.

    abstract::Understanding the mental states of others entails a number of cognitive processes known as Theory of Mind (ToM). A relationship between ToM deficits and executive disorders has been hypothesized in individuals with Parkinson's disease (PD). The present study was aimed at investigating the effect of dysexecutive defici...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-129018

    authors: Costa A,Peppe A,Martini M,Coletta K,Oliveri M,Caltagirone C,Carlesimo GA

    更新日期:2013-01-01 00:00:00

  • Metabolic Risk Factors of Alzheimer's Disease, Dementia with Lewy Bodies, and Normal Elderly: A Population-Based Study.

    abstract:Background:Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) share many risk factors. Evidence suggests that metabolic risk factors are important to AD; however, their association with DLB is unclear. The risk of cardiovascular diseases (CVD) associated with AD and DLB is also uncertain. Thus, this nationwid...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2018/8312346

    authors: Cheng CK,Tsao YC,Su YC,Sung FC,Tai HC,Kung WM

    更新日期:2018-06-03 00:00:00

  • Lack of noradrenergic modulation of indirect semantic priming.

    abstract::Norepinephrine and dopamine are both believed to affect signal-to-noise in the cerebral cortex. Dopaminergic agents appear to modulate semantic networks during indirect semantic priming, but do not appear to affect problem solving dependent on access to semantic networks. Noradrenergic agents, though, do affect semant...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-2009-0236

    authors: Cios JS,Miller RF,Hillier A,Tivarus ME,Beversdorf DQ

    更新日期:2009-01-01 00:00:00

  • Prevalence and Associated Factors of Depressive Symptoms in Patients with Myasthenia Gravis: A Cross-Sectional Study of Two Tertiary Hospitals in Riyadh, Saudi Arabia.

    abstract:Objectives:This study is aimed at elucidating the prevalence of depression in patients with myasthenia gravis (MG) and examining the risk factors associated with depression. Methods:We evaluated adult patients with MG who were recruited from two tertiary hospitals in the central region (Riyadh) of Saudi Arabia. Data w...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2019/9367453

    authors: Alanazy MH

    更新日期:2019-09-15 00:00:00

  • Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo.

    abstract::Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography (PET) with (11)carbon-labelled Pittsburgh Compound-B ((11)C-PIB), ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.3233/BEN-2009-0232

    authors: Rabinovici GD,Jagust WJ

    更新日期:2009-01-01 00:00:00

  • Antiepileptic Drug Nonadherence and Its Predictors among People with Epilepsy.

    abstract::Introduction. Antiepileptic drugs are effective in the treatment of epilepsy to the extent that about 70% of people with epilepsy can be seizure-free, but poor adherence to medication is major problem to sustained remission and functional restoration. The aim of this study was to assess the prevalence and associated f...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2016/3189108

    authors: Getnet A,Woldeyohannes SM,Bekana L,Mekonen T,Fekadu W,Menberu M,Yimer S,Assaye A,Belete A,Belete H

    更新日期:2016-01-01 00:00:00

  • A Proposed Neurological Interpretation of Language Evolution.

    abstract::Since the very beginning of the aphasia history it has been well established that there are two major aphasic syndromes (Wernicke's-type and Broca's-type aphasia); each one of them is related to the disturbance at a specific linguistic level (lexical/semantic and grammatical) and associated with a particular brain dam...

    journal_title:Behavioural neurology

    pub_type: 杂志文章,评审

    doi:10.1155/2015/872487

    authors: Ardila A

    更新日期:2015-01-01 00:00:00

  • Computed tomographic density changes in schizophrenic and manic Nigerian subjects.

    abstract::There is paucity of computed tomography (CT) studies from developing countries, where schizophrenia is said to have more favourable outcome and present predominantly with positive symptoms. We highlight the densitometric analysis of frontal and parietal areas, assessed by tracing of regions of interest on the slice th...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1995-8104

    authors: Ohaeri JU,Adeyinka AO,Osuntokun BO

    更新日期:1995-01-01 00:00:00

  • Objectively Measured Physical Activity Is Associated with Brain Volumetric Measurements in Multiple Sclerosis.

    abstract:BACKGROUND:Little is known about physical activity and its association with volumes of whole brain gray matter and white matter and deep gray matter structures in persons with multiple sclerosis (MS). PURPOSE:This study examined the association between levels of physical activity and brain volumetric measures from mag...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2015/482536

    authors: Klaren RE,Hubbard EA,Motl RW,Pilutti LA,Wetter NC,Sutton BP

    更新日期:2015-01-01 00:00:00

  • Efficacy of Cognitive Rehabilitation Therapy on Poststroke Depression among Survivors of First Stroke Attack in Ibadan, Nigeria.

    abstract:BACKGROUND AND PURPOSE:Poststroke depression (PSD) is a common complication after stroke. There is no adequate treatment for PSD. This study examined efficacy of cognitive rehabilitation therapy (CRT) in the treatment of PSD among stroke survivors. METHODS:An experimental design, 30 participants with poststroke depres...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.1155/2017/4058124

    authors: Olukolade O,Osinowo HO

    更新日期:2017-01-01 00:00:00

  • Empirical research on déjà vu experiences: a review.

    abstract::A déjà vu experience is a dissociative phenomenon, which can be characterized as a subjectively inappropriate impression of familiarity of the present with an undefined past. This paper reviews empirical studies on déjà vu experiences and summarizes the most salient findings. Overall, the findings appear to be inconsi...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1992-5303

    authors: Sno HN,Schalken HF,de Jonghe F

    更新日期:1992-01-01 00:00:00

  • Alien Hand Sign and Other Cognitive Deficits following Ruptured Aneurysm of the Anterior Communicating Artery.

    abstract::We describe a right-handed patient who suffered a ruptured aneurysm of the anterior communicating artery (ACoA) which was clipped successfully. Computerized tomography indicated a low density area in the genu of the corpus callosum and the infero-lateral aspect of the left frontal lobe. On recovery the patient's most ...

    journal_title:Behavioural neurology

    pub_type: 杂志文章

    doi:10.3233/BEN-1991-4305

    authors: Parkin AJ,Barry C

    更新日期:1991-01-01 00:00:00