Abstract:
:Presently, there are no valid biomarkers to identify individuals with eating disorders (ED). The aim of this work was to assess the feasibility of a machine learning method for extracting reliable neuroimaging features allowing individual categorization of patients with ED. Support Vector Machine (SVM) technique, combined with a pattern recognition method, was employed utilizing structural magnetic resonance images. Seventeen females with ED (six with diagnosis of anorexia nervosa and 11 with bulimia nervosa) were compared against 17 body mass index-matched healthy controls (HC). Machine learning allowed individual diagnosis of ED versus HC with an Accuracy ≥ 0.80. Voxel-based pattern recognition analysis demonstrated that voxels influencing the classification Accuracy involved the occipital cortex, the posterior cerebellar lobule, precuneus, sensorimotor/premotor cortices, and the medial prefrontal cortex, all critical regions known to be strongly involved in the pathophysiological mechanisms of ED. Although these findings should be considered preliminary given the small size investigated, SVM analysis highlights the role of well-known brain regions as possible biomarkers to distinguish ED from HC at an individual level, thus encouraging the translational implementation of this new multivariate approach in the clinical practice.
journal_name
Behav Neuroljournal_title
Behavioural neurologyauthors
Cerasa A,Castiglioni I,Salvatore C,Funaro A,Martino I,Alfano S,Donzuso G,Perrotta P,Gioia MC,Gilardi MC,Quattrone Adoi
10.1155/2015/924814subject
Has Abstractpub_date
2015-01-01 00:00:00pages
924814eissn
0953-4180issn
1875-8584journal_volume
2015pub_type
杂志文章abstract::The term functional amnesia (FA) has been proposed for cases of memory impairment presenting with severe retrograde amnesia in the absence of cerebral injury or history of psychiatric disturbance. Emotional flattening has often been reported alongside FA, however the mechanism of such a modification is unknown. This s...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2008/245495
更新日期:2008-01-01 00:00:00
abstract:Background:Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) share many risk factors. Evidence suggests that metabolic risk factors are important to AD; however, their association with DLB is unclear. The risk of cardiovascular diseases (CVD) associated with AD and DLB is also uncertain. Thus, this nationwid...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/8312346
更新日期:2018-06-03 00:00:00
abstract:INTRODUCTION:Gilles de la Tourette Syndrome (GTS) is a childhood-onset hyperkinetic movement disorder defined by the chronic presence of multiple motor tics and at least one vocal tic and often complicated by co-morbid behavioural problems. The pharmacological treatment of GTS focuses on the modulation of monoaminergic...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-2012-120269
更新日期:2013-01-01 00:00:00
abstract::Aiming and tapping movements were analysed repeatedly over a three-week period in a patient who was hemideafferented due to an ischaemic posterior thalamic lesion. Contrasting behaviour observed in six healthy subjects, nine hemiparetic patients and one patient with hemianopic stroke, allowed the determination of beha...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1997-10103
更新日期:1997-01-01 00:00:00
abstract::Tardive dystonia was identified in 25 patients: involvement of the face and neck was most common; truncal and limb dystonia were also observed. There were 3 cases of laryngospasm and 2 of spasmodic dysphonia. The latter has not been previously reported as a manifestation of tardive dystonia. In all cases, movements ty...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1988-1106
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to analyze the effect of a neuropsychological rehabilitation (NR) program on patients with Alzheimer's disease (AD). METHODS:The sample was composed of 16 elderly outpatients who participated in an open trial with rivastigmine (6 to 12 mg/day) for 4 months and were randomized to...
journal_title:Behavioural neurology
pub_type: 杂志文章,随机对照试验
doi:10.1155/2007/915816
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Thalamic lesions are seen in a multitude of disorders including vascular diseases, metabolic disorders, inflammatory diseases, trauma, tumours, and infections. In some diseases, thalamic involvement is typical and sometimes isolated, while in other diseases thalamic lesions are observed only occasionally (of...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2014/154631
更新日期:2014-01-01 00:00:00
abstract::Despite a vast literature examining semantic impairment in Alzheimer's disease (AD), consensus regarding the nature of the deficit remains elusive. We re-considered this issue in the context of a framework that assumes semantic cognition can break down in two ways: (1) core semantic representations can degrade or (2) ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2012-0346
更新日期:2012-01-01 00:00:00
abstract::The present study is aimed at identifying the most prominent determinants of OCD along with their strength to classify the OCD patients from healthy controls. The data for this cross-sectional study were collected from 200 diagnosed OCD patients and 400 healthy controls. The respondents were selected through purposive...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/2678718
更新日期:2020-06-22 00:00:00
abstract::Juxtaposed alongside the ongoing rise in the incidence and prevalence of dementia, is the surge of recent research confirming widespread exposure and bioaccumulation of chemical toxicants. Evidence from sources such as the Centers for Disease Control reveals that most people have accrued varying degrees of assorted to...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/620143
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The extent of brain damage in chronic stroke patients is traditionally defined as the necrotic tissue observed on magnetic resonance image (MRI). However, patients often exhibit symptoms suggesting that functional impairment may affect areas beyond the cortical necrotic lesion, for example, when cortical sym...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/215380
更新日期:2014-01-01 00:00:00
abstract::Three points of interest lie in considering how Alzheimer, and more significantly Perusini, struggled to throw light on the cause of this devastating disease. There is a stimulating possibility that Perusini believed presenile forms of Alzheimer's disease described the same disease as senile forms. If so this would an...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1997-10401
更新日期:1997-01-01 00:00:00
abstract::Understanding the mental states of others entails a number of cognitive processes known as Theory of Mind (ToM). A relationship between ToM deficits and executive disorders has been hypothesized in individuals with Parkinson's disease (PD). The present study was aimed at investigating the effect of dysexecutive defici...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-129018
更新日期:2013-01-01 00:00:00
abstract::We describe a cross-sectional study of aggressive behaviour in a sample of patients suffering from Huntington's disease in a residential nursing home. Data were obtained using the RAGE, a behaviourally oriented rating scale for measuring aggressive behaviour in cognitively impaired patients. Nursing staff rated 27 pat...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1993-6107
更新日期:1993-01-01 00:00:00
abstract::Frontotemporal dementia (FTD) affects behavior, language, and personality. This study aims to explore functional connectivity changes in three FTD variants: behavioral (bvFTD), semantic (svPPA), and nonfluent variant (nfvPPA). Seventy-six patients diagnosed with FTD by international criteria and thirty-two controls we...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/9684129
更新日期:2018-04-01 00:00:00
abstract::Psychogenic amnesia is a complex disorder characterised by a wide variety of symptoms. Consequently, in a number of cases it is difficult distinguish it from organic memory impairment. The present study reports a new case of global psychogenic amnesia compared with two patients with amnesia underlain by organic brain ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2007/193140
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Apathy and reduced emotion-based decision-making are two behavioral modifications independently described in Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). OBJECTIVES:The aims of this study were to investigate decision-making based on emotional feedback processing in AD and aMCI and...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/231469
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Increasing proportion of the elderly in the driving population raises the importance of assuring their safety. We explored the effects of three different types of cognitive training on the cognitive function, brain structure, and driving safety of the elderly. METHODS:Thirty-seven healthy elderly daily driv...
journal_title:Behavioural neurology
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/525901
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Tourette syndrome (TS) is a neuropsychiatric disorder with childhood onset characterized by chronic motor and vocal tics. The typical clinical course of an attenuation of symptoms during adolescence in parallel with the emerging self-regulatory control during development suggests that plastic processes may p...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-120294
更新日期:2013-01-01 00:00:00
abstract:Objective:To compare baseline and 72-hour hormone levels in women with traumatic brain injury (TBI) and controls. Setting:Hospital emergency department. Participants:21 women ages 18-35 with TBI and 21 controls. Design:Repeated measures. Main Measures:Serum samples at baseline and 72 hours; immunoassays for estradi...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2019/7694503
更新日期:2019-02-12 00:00:00
abstract:Objectives:To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods:An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH. The hematoma ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/6583267
更新日期:2018-08-12 00:00:00
abstract:BACKGROUND:Patients with clinically isolated syndrome (CIS) demonstrate brain hemodynamic changes and also suffer from difficulties in processing speed, memory, and executive functions. OBJECTIVE:To explore whether brain hemodynamic disturbances in CIS patients correlate with executive functions. METHODS:Thirty CIS p...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/252419
更新日期:2014-01-01 00:00:00
abstract::Neuropsychological studies of memory disorders have played a prominent role in the development of theories of memory. To test and refine such theories in future, it will be advantageous to include research that utilizes physiological measures of the neural events responsible for memory. Measures of the electrical acti...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2000/865250
更新日期:2000-01-01 00:00:00
abstract::A case of late onset sporadic startle syndrome in a patient with a right posterior fossa brain tumour is reported. The exaggerated startle response did not respond to treatment with clonazepam. In addition to anxiety and depression, the patient developed obsessive- compulsive symptoms which responded to behavioural th...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/1998/617160
更新日期:1998-01-01 00:00:00
abstract::We report findings from a cognitive neuropsychological and psychophysiological investigation of a patient who displayed an exacerbated acute emotional expression during movement, innocuous, and aversive somatosensory stimulation. The condition developed in the context of non-specific white matter ischaemia along with ...
journal_title:Behavioural neurology
pub_type: 临床试验,杂志文章
doi:10.1155/2004/458327
更新日期:2004-01-01 00:00:00
abstract::Gaining a driver's licence represents increased independence and can lead to improved quality of life for individuals and their families. Learning to drive a motor vehicle and maintaining safe on-road skills are often more difficult for people on the autism spectrum. Many countries currently have no autism-specific li...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2018/6842306
更新日期:2018-08-28 00:00:00
abstract::A large amount of research has been conducted on the effects of sex hormones on gender differences in patients with depression, yet research on cognitive differences between male and female patients with depression is insufficient. This study uses emotion pictures to investigate the differences of the emotional workin...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/807343
更新日期:2015-01-01 00:00:00
abstract::The case is reported of a patient (PS) who, following acute encephalitis with residual occipito-temporal damage, showed a selective deficit in writing cursive letters in isolation, but no difficulty to write cursive-case words and non-words. Notably, he was able to recognize the same allographs he could not write and ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2012-119008
更新日期:2012-01-01 00:00:00
abstract::The jugular venous pulse (JVP) provides valuable information about cardiac haemodynamics and filling pressures and is an indirect estimate of the central venous pressure (CVP). Recently it has been proven that JVP can be obtained by measuring the cross-sectional area (CSA) of the IJV on each sonogram of an ultrasound ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/170756
更新日期:2015-01-01 00:00:00
abstract:Objective:The aim of this study is to explore the relationship between neuron-specific enolase (NSE) gene polymorphism and delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) and provide a theoretical basis for DEACMP pathogenesis, diagnosis, and prognosis. Methods:To investigate this relationship, w...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2020/8819210
更新日期:2020-10-14 00:00:00