Abstract:
:The global workspace (GW) theory proposes that conscious processing results from coherent neuronal activity between widely distributed brain regions, with fronto-parietal associative cortices as key elements. In this model, transition between conscious and non conscious states are predicted to be caused by abrupt non-linear massive changes of the level of coherence within this distributed neural space. Epileptic seizures offer a unique model to explore the validity of this central hypothesis. Seizures are often characterized by the occurrence of brutal alterations of consciousness (AOC) which are largely negatively impacting patients' lives. Recently, we have shown that these sudden AOC are contemporary to non-linear increases of neural synchrony within distant cortico-cortical and cortico-thalamic networks. We interpreted these results in the light of GW theory, and suggested that excessive synchrony could prevent this distributed network to reach the minimal level of differentiation and complexity necessary to the coding of conscious representations. These observations both confirm some predictions of the GW model, and further specify the physiological window of neural coherence (minimum and maximum) associated with conscious processing.
journal_name
Behav Neuroljournal_title
Behavioural neurologyauthors
Bartolomei F,Naccache Ldoi
10.3233/BEN-2011-0313subject
Has Abstractpub_date
2011-01-01 00:00:00pages
67-74issue
1eissn
0953-4180issn
1875-8584pii
J622M6V172627200journal_volume
24pub_type
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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更新日期:2007-01-01 00:00:00
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doi:10.1155/2008/814846
更新日期:2008-01-01 00:00:00
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journal_title:Behavioural neurology
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