Structural neuroimaging in the detection and prognosis of pre-clinical and early AD.

Abstract:

:Current research supports the strong potential of structural MRI profiles, even within cross-sectional designs, as a promising method for the discrimination of Alzheimer's Disease (AD) from normal controls and for the prediction of Mild Cognitive Impairment (MCI) progression and conversion to AD. Findings suggest that measures of structural change in mesial and lateral temporal, cingulate, parietal and midfrontal areas may facilitate the assessment of a treatment's ability to halt the progressive structural loss that accompanies clinical decline in MCI. The performance of prediction is likely to continue to improve with the incorporation of measures from other neuroimaging modalities, clinical assessments, and neuromedical biomarkers, as the regional profile of individuals at risk for progression is refined.

journal_name

Behav Neurol

journal_title

Behavioural neurology

authors

Fennema-Notestine C,McEvoy LK,Hagler DJ Jr,Jacobson MW,Dale AM,The Alzheimer's Disease Neuroimaging Initiative.

doi

10.3233/BEN-2009-0230

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

3-12

issue

1

eissn

0953-4180

issn

1875-8584

pii

1754807741161848

journal_volume

21

pub_type

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