Abstract:
:Current research supports the strong potential of structural MRI profiles, even within cross-sectional designs, as a promising method for the discrimination of Alzheimer's Disease (AD) from normal controls and for the prediction of Mild Cognitive Impairment (MCI) progression and conversion to AD. Findings suggest that measures of structural change in mesial and lateral temporal, cingulate, parietal and midfrontal areas may facilitate the assessment of a treatment's ability to halt the progressive structural loss that accompanies clinical decline in MCI. The performance of prediction is likely to continue to improve with the incorporation of measures from other neuroimaging modalities, clinical assessments, and neuromedical biomarkers, as the regional profile of individuals at risk for progression is refined.
journal_name
Behav Neuroljournal_title
Behavioural neurologyauthors
Fennema-Notestine C,McEvoy LK,Hagler DJ Jr,Jacobson MW,Dale AM,The Alzheimer's Disease Neuroimaging Initiative.doi
10.3233/BEN-2009-0230subject
Has Abstractpub_date
2009-01-01 00:00:00pages
3-12issue
1eissn
0953-4180issn
1875-8584pii
1754807741161848journal_volume
21pub_type
杂志文章,评审abstract::Cognitive impairment is frequently encountered in multiple sclerosis (MS) affecting between 40-65% of individuals, irrespective of disease duration and severity of physical disability. In the present multicenter randomized controlled trial, fifty-eight clinically stable RRMS patients with mild to moderate cognitive im...
journal_title:Behavioural neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1155/2017/5919841
更新日期:2017-01-01 00:00:00
abstract::The global workspace (GW) theory proposes that conscious processing results from coherent neuronal activity between widely distributed brain regions, with fronto-parietal associative cortices as key elements. In this model, transition between conscious and non conscious states are predicted to be caused by abrupt non-...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.3233/BEN-2011-0313
更新日期:2011-01-01 00:00:00
abstract::Dementia of frontal lobe type may precede motor signs in a number of adult patients with amyotrophy. Neuropathological studies have shown neuron loss, spongiosis and gliosis mainly in layers II and III of the frontal and temporal lobes, together with myelin pallor of the subcortical white matter. Golgi studies reveale...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1992-5204
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:The prevalence of psychiatric disturbance for patients with multiple sclerosis (MS) is higher than that observed in other chronic health conditions. We report three cases of MS and bipolar disorder and we discuss the possible etiological hypothesis and treatment options. OBSERVATIONS:All patients fulfilled ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/536503
更新日期:2014-01-01 00:00:00
abstract::Neurologists and neuropsychologists are aware that aging men are more at risk than women for brain damage, principally because of the well known male-predominant risk for cardiovascular disease and related cerebrovascular accidents. However, a disproportion in prevalence of brain damage between the sexes in childhood ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2002/634764
更新日期:2001-01-01 00:00:00
abstract::Juxtaposed alongside the ongoing rise in the incidence and prevalence of dementia, is the surge of recent research confirming widespread exposure and bioaccumulation of chemical toxicants. Evidence from sources such as the Centers for Disease Control reveals that most people have accrued varying degrees of assorted to...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/620143
更新日期:2015-01-01 00:00:00
abstract::The aim of the present paper was to investigate the fundamental ethical issues of Deep Brain Stimulation (DBS) on patients remaining in Persistent Vegetative State (PVS). First, the purpose of this analysis was to discuss the nature of this intervention in order to classify it such as an ordinary clinical practice, or...
journal_title:Behavioural neurology
pub_type: 杂志文章,评审
doi:10.1155/2014/641213
更新日期:2014-01-01 00:00:00
abstract::The present study examined the differential contribution of cortical and subcortical brain structures in emotional processing by comparing patients with focal cortical lesions (n = 32) to those with primarily subcortical dysregulation of the basal ganglia (Parkinson's disease n = 14). A standardized measure of emotion...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/1998/579029
更新日期:1998-01-01 00:00:00
abstract::Understanding the mental states of others entails a number of cognitive processes known as Theory of Mind (ToM). A relationship between ToM deficits and executive disorders has been hypothesized in individuals with Parkinson's disease (PD). The present study was aimed at investigating the effect of dysexecutive defici...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-129018
更新日期:2013-01-01 00:00:00
abstract::We describe a right-handed patient who suffered a ruptured aneurysm of the anterior communicating artery (ACoA) which was clipped successfully. Computerized tomography indicated a low density area in the genu of the corpus callosum and the infero-lateral aspect of the left frontal lobe. On recovery the patient's most ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1991-4305
更新日期:1991-01-01 00:00:00
abstract::Pathological laughter is an uncommon symptom usually caused by bilateral, diffuse cerebral lesions. It has rarely been reported in association with isolated cerebral lesions. Midbrain involvement causing pathological laughter is extremely unusual. We describe three patients who developed pathological laughter after mi...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2004/409248
更新日期:2004-01-01 00:00:00
abstract::Norepinephrine and dopamine are both believed to affect signal-to-noise in the cerebral cortex. Dopaminergic agents appear to modulate semantic networks during indirect semantic priming, but do not appear to affect problem solving dependent on access to semantic networks. Noradrenergic agents, though, do affect semant...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2009-0236
更新日期:2009-01-01 00:00:00
abstract:Objective:To compare baseline and 72-hour hormone levels in women with traumatic brain injury (TBI) and controls. Setting:Hospital emergency department. Participants:21 women ages 18-35 with TBI and 21 controls. Design:Repeated measures. Main Measures:Serum samples at baseline and 72 hours; immunoassays for estradi...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2019/7694503
更新日期:2019-02-12 00:00:00
abstract::The serum concentration achieved and maintained following the administration of a fixed drug dosage is a direct consequence of the interactions of a wide variety of interrelated processes, including drug absorption, distribution, metabolism, and excretion, and the physiological status of the patient. These interrelati...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1990-31S102
更新日期:1990-01-01 00:00:00
abstract::We report a right-handed man who developed selective Kana (phonogram) agraphia following an infarct in the non-dominant right cerebral hemisphere. His ability for comprehension, reading and writing of Kanji (ideogram) was unaffected. Kana errors consisted of substitution with another letter and the number of target wo...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1995-8208
更新日期:1995-01-01 00:00:00
abstract::Patients with unilateral neglect are impaired at making saccades to contralesional targets. Whether this problem arises from a deficit in perception, in planning the saccade or in executing the eye movement or some combination thereof remains unclear. We measured several variables related to the initiation and executi...
journal_title:Behavioural neurology
pub_type: 临床试验,杂志文章
doi:10.1155/2002/253201
更新日期:2001-01-01 00:00:00
abstract::Introduction. Antiepileptic drugs are effective in the treatment of epilepsy to the extent that about 70% of people with epilepsy can be seizure-free, but poor adherence to medication is major problem to sustained remission and functional restoration. The aim of this study was to assess the prevalence and associated f...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2016/3189108
更新日期:2016-01-01 00:00:00
abstract::Visual reaction time (RT) studies on patients with right hemisphere (RH) damage have demonstrated that the attentional imbalance to stimuli occupying left and right positions exists even within the "intact" ipsilesional hemifield. The purpose of the present study was to test whether such patients might also exhibit re...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1994-7204
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Increasing proportion of the elderly in the driving population raises the importance of assuring their safety. We explored the effects of three different types of cognitive training on the cognitive function, brain structure, and driving safety of the elderly. METHODS:Thirty-seven healthy elderly daily driv...
journal_title:Behavioural neurology
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/525901
更新日期:2015-01-01 00:00:00
abstract:Objectives:To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods:An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH. The hematoma ...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/6583267
更新日期:2018-08-12 00:00:00
abstract:BACKGROUND:Tacrolimus-associated encephalopathy (TAC-E) is usually described under the term of posterior reversible encephalopathy syndrome (PRES). However, a large amount of data has suggested that TAC-E is not a homogenous entity: indeed, TAC-E which is often presented with atypical and potentially misleading imaging...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2014/931808
更新日期:2014-01-01 00:00:00
abstract::The paper examines the ability of Statistical Parametric Mapping (SPM) to contribute towards the quantitative analysis of HMPAO SPECT images containing lesions. A validation study is described in which SPECT images were created that contained synthetic lesions and were analysed with SPM. The study established a set of...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2000/681916
更新日期:2000-01-01 00:00:00
abstract::A large amount of research has been conducted on the effects of sex hormones on gender differences in patients with depression, yet research on cognitive differences between male and female patients with depression is insufficient. This study uses emotion pictures to investigate the differences of the emotional workin...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2015/807343
更新日期:2015-01-01 00:00:00
abstract::Dementia with Lewy bodies (DLB) is the second most common degenerative dementia of the central nervous system. The technique 18F-fluorodeoxyglucose positron emission tomography (18F FDG PET) was used to investigate brain metabolism patterns in DLB patients. Conventional statistical methods did not consider intern meta...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.1155/2018/8420658
更新日期:2018-05-08 00:00:00
abstract::We describe a cross-sectional study of aggressive behaviour in a sample of patients suffering from Huntington's disease in a residential nursing home. Data were obtained using the RAGE, a behaviourally oriented rating scale for measuring aggressive behaviour in cognitively impaired patients. Nursing staff rated 27 pat...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1993-6107
更新日期:1993-01-01 00:00:00
abstract::Since the Korean language has two distinct writing systems, phonogram (Hangul) and ideogram (Hanja: Chinese characters), alexia can present with dissociative disturbances in reading between the two systems. A 74-year-old right-handed man presented with a prominent reading impairment in Hangul with agraphia of both Han...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-2008-0211
更新日期:2008-01-01 00:00:00
abstract::We present a patient who developed severe ideomotor apraxia (IA) and subcortical aphasia after a hemorrhage involving the posterior part of the left thalamus and the posterior limb of the internal capsule. The cerebral blood flow (CBF) of the left hemisphere as measured by 99Tc-HM-PAO SPECT was initially diminished as...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1991-4102
更新日期:1991-01-01 00:00:00
abstract::All published studies on micrographia, a diminution of letter size, examine handwriting in the horizontal direction. Writing horizontally typically requires increased wrist extension as handwriting progresses from left to right. Chinese characters, however, can be written not only horizontally from left to right, but ...
journal_title:Behavioural neurology
pub_type: 杂志文章,随机对照试验
doi:10.3233/BEN-120285
更新日期:2013-01-01 00:00:00
abstract::A déjà vu experience is a dissociative phenomenon, which can be characterized as a subjectively inappropriate impression of familiarity of the present with an undefined past. This paper reviews empirical studies on déjà vu experiences and summarizes the most salient findings. Overall, the findings appear to be inconsi...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1992-5303
更新日期:1992-01-01 00:00:00
abstract::This study examined hemispatial bias in a free-viewing condition of the judgement of facial expressions of emotions. Right-handed male subjects were asked to judge the intensity, in terms of expressiveness, of facial emotion in normal and mirror-reversed orientations. Expressions in mirror-reversed orientation were pe...
journal_title:Behavioural neurology
pub_type: 杂志文章
doi:10.3233/BEN-1996-93-402
更新日期:1996-01-01 00:00:00