Abstract:
:Pathological laughter is an uncommon symptom usually caused by bilateral, diffuse cerebral lesions. It has rarely been reported in association with isolated cerebral lesions. Midbrain involvement causing pathological laughter is extremely unusual. We describe three patients who developed pathological laughter after midbrain and pontine-midbrain infarction. In two patients a small infarction in the left paramedian midbrain was detected, whereas the third one sustained a massive bilateral pontine infarction extending to the midbrain. Laughter heralded stroke by one day in one patient and occurred as a delayed phenomenon three months after stroke in another. Pathological laughter ceased within a few days in two patients and was still present at a two year follow-up in the patient with delayed-onset laughter. Pathological laughter can herald midbrain infarction or follow stroke either shortly after onset of symptoms or as a delayed phenomenon. Furthermore, small unilateral midbrain infarctions can cause this rare complication.
journal_name
Behav Neuroljournal_title
Behavioural neurologyauthors
Dabby R,Watemberg N,Lampl Y,Eilam A,Rapaport A,Sadeh Mdoi
10.1155/2004/409248subject
Has Abstractpub_date
2004-01-01 00:00:00pages
73-6issue
3-4eissn
0953-4180issn
1875-8584journal_volume
15pub_type
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