Emotional dysfunction in Parkinson's disease.

Abstract:

:In addition to motor symptomatology, idiopathic Parkinson's disease is characterized by emotional dysfunction. Depression affects some 30 to 40 percent of Parkinson patients and other psychiatric co-morbidities include anxiety and apathy. Neuropsychological and neuroimaging studies of emotional dysfunction in Parkinson patients suggest abnormalities involving mesolimbic and mesocortical dopaminergic pathways. There is also evidence suggesting that the interaction between serotonin and dopamine systems is important in the understanding and treatment of mood disorders in Parkinson's disease. In this review we discuss the neuropsychiatric abnormalities that accompany Parkinson's disease and describe their neuropsychological, neuropharmacologic, and neuroimaging concomitants.

journal_name

Behav Neurol

journal_title

Behavioural neurology

authors

Blonder LX,Slevin JT

doi

10.3233/BEN-2011-0329

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

201-17

issue

3

eissn

0953-4180

issn

1875-8584

pii

62H2345P40KW8297

journal_volume

24

pub_type

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