Abstract:
:Zirconia-based ceramics is widely used in dentistry. Different compositions of ceramics have different features. Our self-renovated ceramics become more machinable without scarifying its dental restoration properties after adjusting ratio of lanthanum phosphate (LaPO4)/yttrium oxide (Y2O3). In order to evaluate its safety, here, we tested its genotoxicity in primary human peripheral lymphocytes. The human lymphocytes cultured on three groups of different ratios of LaPO4/Y2O3 diphase ceramics for 6 days showed little effect of growth inhibition and similar effect of growth trend to the negative control. Furthermore, single-cell gel electrophoresis (comet assay) indicated that there was no significant difference of the value of tail moment between the tested ceramics and negative control, the IPS Empress II (P > 0.05). Our findings implicate that our self-renovated ceramics do not induce DNA damages in human peripheral lymphocytes and support their future clinic application.
journal_name
Cell Biochem Biophysjournal_title
Cell biochemistry and biophysicsauthors
Hua N,Zhu H,Zhuang J,Chen Ldoi
10.1007/s12013-014-0127-xsubject
Has Abstractpub_date
2014-12-01 00:00:00pages
1773-7issue
3eissn
1085-9195issn
1559-0283journal_volume
70pub_type
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