The Role of Arachidonic Acid Metabolism in Myocardial Ischemia-Reperfusion Injury.

Abstract:

:Patients with myocardial ischemic diseases or who are undergoing one of various heart treatments, such as open heart surgery, coronary artery bypass grafting, percutaneous coronary artery intervention or drug thrombolysis, face myocardial ischemia-reperfusion injury (MIRI). However, no effective treatment is currently available for MIRI. To improve the prognosis of people with cardiovascular disease, it is important to research the mechanism of MIRI. Arachidonic acid (AA) is one of the focuses of current research. The various metabolic pathways of AA are closely related to the development of cardiovascular disease, and the roles of various metabolites in ischemia-reperfusion injury have gradually been confirmed. AA is mainly metabolized in the cyclooxygenase (COX) pathway, lipoxygenase (LOX) pathway, and cytochrome P450 monooxygenase (CYP) pathway. This paper summarizes the progress of research on these three major AA metabolic pathways with respect to MIRI.

journal_name

Cell Biochem Biophys

authors

Zhang C,He M,Ni L,He K,Su K,Deng Y,Li Y,Xia H

doi

10.1007/s12013-020-00928-z

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

255-265

issue

3

eissn

1085-9195

issn

1559-0283

pii

10.1007/s12013-020-00928-z

journal_volume

78

pub_type

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