Modulation of cell signaling pathways by Kaposi's sarcoma-associated herpesvirus (KSHVHHV-8).


:Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8, has been associated with the development of Kaposi's sarcoma, pleural effusion lymphoma, and multicentric Castleman's disease. KSHV is a double-stranded DNA virus that has been classified as a gammaherpesvirus. The viral genome is approx 160 kb long and encodes for several genes that are involved in cell signaling pathways. These include genes that are unique to the virus as well as viral homologues of cellular genes. The latter are likely to have been usurped from the host genome and include both virokines and viral receptor proteins. This article reviews how these KSHV proteins modulate cellular signal transduction pathways.


Cell Biochem Biophys


Damania B




Has Abstract


2004-01-01 00:00:00














  • Influence of topoisomerase II inhibitors and ionizing radiation on growth arrest and cell death pathways in the breast tumor cell.

    abstract::Promotion of apoptosis (which is frequently dependent on functional p53) is thought to be critical for the effectiveness of chemotherapy or radiotherapy. Studies in this as well as other laboratories have demonstrated that breast tumor cells are relatively refractory to apoptosis in response to modalities that induce ...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,评审


    authors: Gewirtz DA,Sundaram S,Magnet KJ

    更新日期:2000-01-01 00:00:00

  • A Controlled Study of Alprostadil Liposomal Preparation in the Treatment of Blue Toe Syndrome.

    abstract::The aim of this study is to examine the efficacy of alprostadil liposomal preparation in the treatment of blue toe syndrome. As many as 32 patients with blue toe syndrome were randomized into the test group and a control group. Patients out of the test group were treated with alprostadil liposomal preparation, while t...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,随机对照试验


    authors: Xi HL,Li R,Tian ZL,Feng S,Jia GL

    更新日期:2015-05-01 00:00:00

  • Determination of concentration of methotrexate enantiomers in intracellular and extracellular fluids of HepG2 cells by liquid chromatography-tandem mass spectrometry.

    abstract::A rapid and sensitive liquid chromatography-tandem mass spectrometry assay (LC-MS/MS) with electrospray ionization was developed and validated for the quantitative determination of the concentration of methotrexate (MTX) enantiomers in intracellular and extracellular fluids of HepG2 cells. The analytes were extracted ...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Wang R,Guo L,Xie H,Zhang J,Li X,Li W,Wang J,Wu X,Jia Z

    更新日期:2013-01-01 00:00:00

  • Coating and selective deposition of nanofilm on silicone rubber for cell adhesion and growth.

    abstract::A recently developed method for surface modification, layer-by-layer (LbL) assembly, has been applied to silicone, and its ability to encourage endothelial cell growth and control cell growth patterns has been examined. The surfaces studied consisted of a precursor, with alternating cationic polyethyleneimine (PEI) an...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Ai H,Lvov YM,Mills DK,Jennings M,Alexander JS,Jones SA

    更新日期:2003-01-01 00:00:00

  • Construction and Application of a Refined Hospital Management Chain.

    abstract::Gaining large scale success was quite common in the later period of industrialization for hospitals in China. Today, Chinese hospital management face such problems as service inefficiency, high human resources cost, and low rate of capital use. This study analyzes the refined management chain of the Wuxi No. 2 People'...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Yi L,Hao A,Hu M,Huang P,Yuan H,Xing M

    更新日期:2015-05-01 00:00:00

  • Effect of miR-21 on renal fibrosis by regulating MMP-9 and TIMP1 in kk-ay diabetic nephropathy mice.

    abstract::MicroRNAs (miRs) play important roles in initiation and progression of many pathologic processes. However, the roles of miRs in diabetic nephropathy remain unclear. This study was to determine whether miR-21 was involved in diabetic nephropathy and to explore the relationship between miR-21 and MMP9/TIMP1 expression i...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Wang J,Gao Y,Ma M,Li M,Zou D,Yang J,Zhu Z,Zhao X

    更新日期:2013-11-01 00:00:00

  • Better prognosis in newborns with trisomy 13 who received intensive treatments: a retrospective study of 16 patients.

    abstract::Intensive treatment for newborns with trisomy 13 is controversial because of their lethal prognosis. We report the better life prognosis of patients with trisomy 13 who received intensive treatment. At our hospital, we provided an intensive management to such patients including resuscitation and surgical procedures as...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Tsukada K,Imataka G,Suzumura H,Arisaka O

    更新日期:2012-07-01 00:00:00

  • Sorting of peroxisomal and mitochondrial carnitine acetyltransferase isozymes in the diploid yeast, Candida tropicalis.

    abstract::Peroxisomal and mitochondrial carnitine acetyltransferase (CAT; EC isozymes are synthesized from the first and second ATG codons of the open reading frame of one gene, Candida tropicalis CAT. Primer extension analysis and RNase protection assay revealed that the peroxisomal CAT, initiating at the second AUG c...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Tanaka A,Ueda M

    更新日期:2000-01-01 00:00:00

  • Curcumin Mediates a Protective Effect Via TLR-4/NF-κB Signaling Pathway in Rat Model of Severe Acute Pancreatitis.

    abstract::Severe acute pancreatitis (SAP) is a common acute abdominal disease. This study was designed to investigate the preventive effects of curcumin on SAP and its possible mechanism of action. We observed increased volume of ascites, serum AMY, IL-6, and TNF-α levels, and expression of TLR-4 and NF-κB mRNA and protein in a...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Zhong K

    更新日期:2015-09-01 00:00:00

  • Structural adaptation in adult rabbit ventricular myocytes: influence of dynamic physical interaction with fibroblasts.

    abstract::The mechanism of induction of cardiomyocyte (CM) dedifferentiation, as seen in chronic hibernating myocardium, is largely unknown. Recently, a cellular model was proposed consisting of long-term cocultures of adult rabbit CMs and cardiac fibroblasts in which typical structural characteristics of hibernation-like dedif...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Driesen RB,Verheyen FK,Dispersyn GD,Thoné F,Lenders MH,Ramaekers FC,Borgers M

    更新日期:2006-01-01 00:00:00

  • Activation of p38 MAPK pathway by hepatitis C virus E2 in cells transiently expressing DC-SIGN.

    abstract::Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) is a cellular receptor for hepatitis C virus for the binding of viral envelope glycoprotein E2. Interaction of DC-SIGN with the E2 may evoke cellular signal transduction implicated in viral pathogenesis. We developed a cell model ...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Chen QL,Zhu SY,Bian ZQ,Zhao LJ,Cao J,Pan W,Qi ZT

    更新日期:2010-01-01 00:00:00

  • Simultaneous Determination of Human Erythrocyte Deformability and Adhesion Energy: A Novel Approach Using a Microfluidic Chamber and the "Glass Effect".

    abstract::The simultaneous determination of adhesion and deformability parameters of erythrocytes was carried out through a microfluidic device, which uses an inverted optical microscope with new image acquisition and analysis technologies. Also, an update of the models describing erythrocyte adhesion and deformation was propos...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Londero CM,Riquelme BD

    更新日期:2020-11-07 00:00:00

  • Novel c.2216T > C (p.I739T) mutation in exon 13 and c.1481T > A (p.L494X) mutation in exon 8 of MUT gene in a female with methylmalonic acidemia.

    abstract::We report herein a 1.5-year-old girl with methylmalonic acidemia (MMA) in whom two missense mutations were found: a novel I739T mutation located in exon 13 and the L494X mutation in exon 8. The results of organic acid test showed a pronounced increase in methylmalonate excretion with increased methylcitrate and 3-OH-p...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Imataka G,Sakamoto O,Yamanouchi H,Yoshihara S,Omura-Hasegawa Y,Tajima G,Arisaka O

    更新日期:2013-09-01 00:00:00

  • On the analysis of large-scale genomic structures.

    abstract::We apply methods from statistical physics (histograms, correlation functions, fractal dimensions, and singularity spectra) to characterize large-scale structure of the distribution of nucleotides along genomic sequences. We discuss the role of the extension of noncoding segments ("junk DNA") for the genomic organizati...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Oiwa NN,Goldman C

    更新日期:2005-01-01 00:00:00

  • Correlations between CT perfusion parameters and vascular endothelial growth factor expression and microvessel density in implanted VX2 lung tumors.

    abstract::To evaluate the correlation between CT perfusion parameters and tumor angiogenesis, expression of VEGF is implanted in VX2 lung tumor. VX2 tumor cells were injected in 15 healthy New Zealand rabbits. After 20 days, tumors with diameter over 7 mm were scanned with 16 row spiral CT. Using Software Perfusion 3, blood flo...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Ling S,Deng D,Mo Y,Zhang X,Guan X,Wei Q

    更新日期:2014-09-01 00:00:00

  • Endothelial signaling in leukocyte transmigration.

    abstract::Leukocyte transendothelial migration is a multistep process coordinated by chemokine receptors, integrins and cell adhesion molecules. The interaction between leukocytes and endothelial cells is accompanied by bidirectional signaling in both cell types, which is initiated following formation of specialized, "docking" ...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,评审


    authors: Hordijk P

    更新日期:2003-01-01 00:00:00

  • The Use of Calcium Channel Blockers in the Treatment of Coronary Spasm and Atrioventricular Block.

    abstract::Calcium channel blockers have been used in the treatment of coronary artery spasm for many years. However, there is insufficient knowledge about their application to treat atrioventricular block caused by coronary spasm. Clinical data of five patients who were diagnosed with coronary spasm caused by atrioventricular b...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Gao B,Zhang Z,Qian J,Cao C,Hua X,Chu M,He X,Zeng H

    更新日期:2015-06-01 00:00:00

  • Expression and localization of estrogen receptor in human breast cancer and its clinical significance.

    abstract::The aim of this study was to analyze the clinicopathologic significance of ERα protein that localized in the cell cytoplasm and/or cell membrane of human breast cancer and explore what kind of protein that the cytoplasm/membrane ERα belongs to. ERα expressions in 61 cases of breast cancer are detected by immunohistoch...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Li L,Wang Q,Lv X,Sha L,Qin H,Wang L,Li L

    更新日期:2015-01-01 00:00:00

  • Danggui sini decoction ameliorates myelosuppression in animal model by upregulating Thrombopoietin expression.

    abstract::Danggui Sini decoction (DSD), a famous Chinese medicine, has been used therapeutically in various diseases. In this study, we tried to investigate whether and how DSD could ameliorate myelosuppression in an animal model, in which myelosuppression is induced by cyclophosphamide treatment. The myelosuppression model was...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Chen QQ,Han X,Wang WM,Zhao L,Chen A

    更新日期:2015-03-01 00:00:00

  • Deciphering Biophysical Modulation in Ovarian Cancer Cells.

    abstract::It has been long known that the oncogenic extracellular environment plays an indispensable role in developing and nurturing cancer cell progression and in resistance to standard treatments. However, by how much the biophysical components of tumour extracellular environment contribute to these processes is uncertain. I...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Sarwar M,Sykes PH,Chitcholtan K,Evans JJ

    更新日期:2021-01-12 00:00:00

  • Azithromycin attenuates fibroblast growth factors induced vascular endothelial growth factor via p38(MAPK) signaling in human airway smooth muscle cells.

    abstract::The airways in asthma and COPD are characterized by an increase in airway smooth muscle (ASM) mass and bronchial vascular changes associated with increased expression of pro-angiogenic growth factors, such as fibroblast growth factors (FGF-1 and FGF-2) and vascular endothelial growth factor (VEGF). We investigated the...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Willems-Widyastuti A,Vanaudenaerde BM,Vos R,Dilisen E,Verleden SE,De Vleeschauwer SI,Vaneylen A,Mooi WJ,de Boer WI,Sharma HS,Verleden GM

    更新日期:2013-11-01 00:00:00

  • Protective effect of recombinant human brain natriuretic peptide on acute renal injury induced by endotoxin in canines.

    abstract::The objective of this study was to evaluate the protective effect of recombinant human brain natriuretic peptide (rhBNP) on endotoxin-induced acute kidney injury (AKI) in canine model of septic shock and its potential mechanisms. Dogs with endotoxin-induced septic shock were subjected to intravenous infusion of saline...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Li N,Jin HX,Song Z,Bai CZ,Cui Y,Gao Y

    更新日期:2014-11-01 00:00:00

  • Characterization of 3-iodothyronamine in vitro dynamics by mathematical modeling.

    abstract::3-Iodothyronamine (T1AM) is regarded as a hormone-like substance thanks to its endogenous nature, its interaction with specific receptors trace amine-associated receptor 1 and its biological effects. We characterized T1AM transport and conversion in an in vitro culture of H9c2 murine cells, after a T1AM bolus injectio...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Orsi G,Ghelardoni S,Saba A,Zucchi R,Vozzi G

    更新日期:2014-01-01 00:00:00

  • Insulin signaling and glucose transport in insulin resistant human skeletal muscle.

    abstract::Insulin increases glucose uptake and metabolism in skeletal muscle by signal transduction via protein phosphorylation cascades. Insulin action on signal transduction is impaired in skeletal muscle from Type 2 diabetic subjects, underscoring the contribution of molecular defects to the insulin resistant phenotype. This...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,评审


    authors: Karlsson HK,Zierath JR

    更新日期:2007-01-01 00:00:00

  • Drug-induced modulation of T lymphocytes as a potential mechanism of susceptibility to infections in patients with multiple myeloma during bortezomib therapy.

    abstract::Bortezomib is effective in the therapy of multiple myeloma (MM), but causes infections that are different from those associated with conventional chemotherapy. It is important to identify the risk factors that facilitate infections associated with bortezomib therapy. In the present report, we sought to (1) define the ...

    journal_title:Cell biochemistry and biophysics

    pub_type: 临床试验,杂志文章


    authors: Li J,Li Y,Huang B,Zheng D,Chen M,Zhou Z

    更新日期:2015-01-01 00:00:00

  • Transarterial Chemoembolization of Giant Liver Haemangioma: A Multi-center Study with 836 Cases.

    abstract::The purpose of the study is to evaluate the effectiveness and safety of transarterial chemoembolization (TACE) with pingyangmycin-lipiodol emulsion for the treatment of symptomatic giant hepatic haemangioma. Four hospitals (The Second Hospital of Shandong University, Qilu Hospital of Shandong University, Shandong Prov...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,多中心研究


    authors: Li Y,Jia Y,Li S,Wang W,Wang Z,Wang Y,Liu B,Wang W,Chang H,Li Z

    更新日期:2015-11-01 00:00:00

  • Combined hepatocellular-cholangiocarcinoma with fever of unknown origin: a case report and review of literature.

    abstract::Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is a rare form of primary liver cancer (PLC). It is difficult to make a correct preoperative diagnosis of cHCC-CC because of the lack of special features of the disease. We here present a case of a 68-year-old man who presented with fluctuant fever, ch...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: E C,Xie Y,Yang Y,Ji D,Li W,Zhang X

    更新日期:2014-05-01 00:00:00

  • Therapeutical effects and mechanism of salubrinal combined with ulinastatin on treating paraquat poisoning.

    abstract::To explore therapeutic effects and underlying mechanism of Salubrinal combined with Ulinastatin (UTI) on acute Paraquat (PQ) poisoning. Four hundred rats were randomly allocated into UTI group, SAL group, SAL + UTI and control group according to random number table with 100 rats in each group. Acute PQ poisoning model...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Guo H,Jiang C,Sun X

    更新日期:2014-12-01 00:00:00

  • Uptake of reconstituted Na,K-ATPase vesicles by isolated lymphocytes measured by FACS, confocal microscopy and spectrofluorometry.

    abstract::Na,K-ATPase (EC, Na,K-ATPase) is a fundamental vital membrane transport and receptor system which, after biosynthesis, is exported to the plasma membrane in inside-out vesicles. Na,K-ATPase can be extracted form the natural membrane and inserted into artificially formed phosphatidylcholine vesicles (liposomes...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Anner BM,Volet B

    更新日期:1999-01-01 00:00:00

  • Correlation of matrix metalloproteinases-1 and tissue inhibitor of metalloproteinases-1 with patient age and grade of lumbar disk herniation.

    abstract::The authors studied the nuclear magnetic resonance films and the expression of MMP-1 and TIMP-1 in disk specimens' of patients who had undergone operations for lumbar disk herniation. Forty-one lumbar disk patients were evaluated imaging for degenerative changes and their disk specimens immunohistochemical expression ...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Xu H,Mei Q,He J,Liu G,Zhao J,Xu B

    更新日期:2014-07-01 00:00:00