Abstract:
:Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8, has been associated with the development of Kaposi's sarcoma, pleural effusion lymphoma, and multicentric Castleman's disease. KSHV is a double-stranded DNA virus that has been classified as a gammaherpesvirus. The viral genome is approx 160 kb long and encodes for several genes that are involved in cell signaling pathways. These include genes that are unique to the virus as well as viral homologues of cellular genes. The latter are likely to have been usurped from the host genome and include both virokines and viral receptor proteins. This article reviews how these KSHV proteins modulate cellular signal transduction pathways.
journal_name
Cell Biochem Biophysjournal_title
Cell biochemistry and biophysicsauthors
Damania Bdoi
10.1385/CBB:40:3:305subject
Has Abstractpub_date
2004-01-01 00:00:00pages
305-22issue
3eissn
1085-9195issn
1559-0283pii
CBB:40:3:305journal_volume
40pub_type
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