Construction of small-caliber, polydioxanone cyclohexanone vascular stents.

Abstract:

:Objective of this article is to construct and characterize a three-layered small-caliber, artificial vascular stent. The outer layer of the stent consisted of small intestine submucosa (SIS), the middle layer was the polydioxanone (PDS) vascular stents, and the inner layer. The SIS and PDS were attached with 8-0 PDS thread. Crosslinking with a 10% collagen/chondroitin sulfate solution and 0.020% glutaraldehyde secured the structure. The stent was implanted into the muscles on both sides of the canines' spine at 2, 4, 12, and 24 weeks. A MTT assay using L-929 cells measured the cytotoxicity of the implant. Histological and microscopy analyses were employed to examine the degradation characteristics of the PDS stent. Biomechanical properties of the stent were tested and compared to those of normal physiological blood vessels. The PDS stent burst pressure (43.5 +/- 8.3) kPa, rupture intensity (19.1 +/- 1.56) N, strain ratio (42.88 +/- 3.16)%, and radial compliance (5.96 +/- 0.87)%/100 mmHg were similar to that of physiological vessels. The cytotoxicity test showed that the PDS stent complied with specifications for biological materials for medical applications, with a cell toxicity ranging from 0 to 1. After 12 weeks, SIS and collagen sponge were completely replaced by fibrous connective tissue. Although there was some degradation of PDS, inflammatory cell infiltration subsided. After 24 weeks, the scaffold material began to absorb the new fibers and became filled with inflammatory cells and macrophages. This artificial vascular stent met the requirements of transplant experiments and should be further investigated for future clinical applications.

journal_name

Cell Biochem Biophys

authors

You Q,Wang F,Duan L,Du X,Xiao M,Shen Z

doi

10.1007/s12013-010-9081-4

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

35-43

issue

1

eissn

1085-9195

issn

1559-0283

journal_volume

57

pub_type

杂志文章
  • Inhibition of intercellular adhesion in herpex simplex virus infection by glycyrrhizin.

    abstract::Herpes simplex virus (HSV) is one of the most common viruses infecting humans and animals. Cellular adhesion is increased in HSV and plays a role in pathogenesis of inflammatory response during this viral infection. In our study, we studied a potential role of glycyrrhizin in disrupting cellular adhesion in HSV. We is...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-011-9271-8

    authors: Huang W,Chen X,Li Q,Li P,Zhao G,Xu M,Xie P

    更新日期:2012-01-01 00:00:00

  • Deciphering Biophysical Modulation in Ovarian Cancer Cells.

    abstract::It has been long known that the oncogenic extracellular environment plays an indispensable role in developing and nurturing cancer cell progression and in resistance to standard treatments. However, by how much the biophysical components of tumour extracellular environment contribute to these processes is uncertain. I...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-020-00964-9

    authors: Sarwar M,Sykes PH,Chitcholtan K,Evans JJ

    更新日期:2021-01-12 00:00:00

  • A causal analysis of intra-abdominal hemorrhage after reduced-size liver transplantation in rat.

    abstract::In this study, we analyzed causes of abdominal hemorrhage after reduced-size liver transplantation in rat. Healthy SD rats (weight range of 260-280 g) underwent liver transplantation, the donors were female and the recipients were male rats. The recipients were, on average, by <10 g heavier than the donors. All operat...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-011-9225-1

    authors: Jing L,Li L,Jiang-Hua R,Sheng-Ning Z,Zhu L,Lai-Bang L,Jiang L

    更新日期:2011-12-01 00:00:00

  • Clinical application of a dendritic cell vaccine raised against heat-shocked glioblastoma.

    abstract::Establishment of a detection platform for glioblastoma-dendritic cell (DC) vaccine preparation and to determine the efficacy of the vaccine in a clinical trial. Autologous glioblastoma-DC vaccine was prepared from a glioblast specimen procured from surgical resection. The specimen was used to enrich the vaccine with p...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-011-9265-6

    authors: Jie X,Hua L,Jiang W,Feng F,Feng G,Hua Z

    更新日期:2012-01-01 00:00:00

  • Glycogen debranching enzyme 6 (AGL), enolase 1 (ENOSF1), ectonucleotide pyrophosphatase 2 (ENPP2_1), glutathione S-transferase 3 (GSTM3_3) and mannosidase (MAN2B2) metabolism computational network analysis between chimpanzee and human left cerebrum.

    abstract::We identified significantly higher expression of the genes glycogen debranching enzyme 6 (AGL), enolase 1 (ENOSF1), ectonucleotide pyrophosphatase 2 (ENPP2_1), glutathione S-transferase 3 (GSTM3_3) and mannosidase (MAN2B2) from human left cerebrums versus chimpanzees. Yet the distinct low- and high-expression AGL, ENO...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-011-9232-2

    authors: Sun L,Wang L,Jiang M,Huang J,Lin H

    更新日期:2011-12-01 00:00:00

  • Applicability of different endovascular methods for treatment of refractory Budd-Chiari syndrome.

    abstract::The study's objective was to evaluate the applicability of different endovascular methods for treatment of refractory type of Budd-Chiari syndrome (BCS) under specific scenarios frequently encountered in patients. The treatment methods were evaluated in 197 patients with the following four types of refractory BCS: les...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-011-9211-7

    authors: Gao Y,Chen S,Yu C

    更新日期:2011-11-01 00:00:00

  • Studies on the expression patterns of class I PI3K catalytic subunits and its prognostic significance in colorectal cancer.

    abstract::The phosphatidylinositol 3-kinase/AKT (PI3K/AKT) pathway plays a critical role in human cancer. We determined the expression patterns of class I PI3K catalytic subunits and evaluated their importance in the development or progression of colorectal cancer (CRC). For this purpose, expression of class I PI3K isoforms was...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-011-9257-6

    authors: Cui B,Tao J,Yang Y

    更新日期:2012-01-01 00:00:00

  • Measuring activity in the ubiquitin-proteasome system: from large scale discoveries to single cells analysis.

    abstract::The ubiquitin-proteasome system (UPS) is the primary pathway responsible for the recognition and degradation of misfolded, damaged, or tightly regulated proteins in addition to performing essential roles in DNA repair, cell cycle regulation, cell migration, and the immune response. While traditional biochemical techni...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,评审

    doi:10.1007/s12013-013-9621-9

    authors: Melvin AT,Woss GS,Park JH,Waters ML,Allbritton NL

    更新日期:2013-09-01 00:00:00

  • Efficacy and safety of right hemihepatectomy through the right retrohepatic tunnel.

    abstract::We wished to study the efficacy and safety of the retrograde ligation of short hepatic veins (SHVs) and the right hepatic vein (HV) through the retrohepatic tunnel in patients who underwent hemihepatectomy due to large hepatic carcinoma in the right lobe of the liver. Right hemihepatectomy was performed in 23 patients...

    journal_title:Cell biochemistry and biophysics

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12013-011-9268-3

    authors: Qin Q,Wang L,Li H,Li A,Ouyang J,Xie S,Liang Z

    更新日期:2012-01-01 00:00:00

  • Analysis of volatile organic compounds liberated and metabolised by human umbilical vein endothelial cells (HUVEC) in vitro.

    abstract::Gas chromatography with mass spectrometric detection combined with head-space needle trap extraction as the pre-concentration technique was applied to identify and quantify volatile organic compounds released or metabolised by human umbilical vein endothelial cells. Amongst the consumed species there were eight aldehy...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-014-0201-4

    authors: Mochalski P,Theurl M,Sponring A,Unterkofler K,Kirchmair R,Amann A

    更新日期:2015-01-01 00:00:00

  • Genotoxicity test of self-renovated ceramics in primary human peripheral lymphocytes.

    abstract::Zirconia-based ceramics is widely used in dentistry. Different compositions of ceramics have different features. Our self-renovated ceramics become more machinable without scarifying its dental restoration properties after adjusting ratio of lanthanum phosphate (LaPO4)/yttrium oxide (Y2O3). In order to evaluate its sa...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-014-0127-x

    authors: Hua N,Zhu H,Zhuang J,Chen L

    更新日期:2014-12-01 00:00:00

  • Drug-induced modulation of T lymphocytes as a potential mechanism of susceptibility to infections in patients with multiple myeloma during bortezomib therapy.

    abstract::Bortezomib is effective in the therapy of multiple myeloma (MM), but causes infections that are different from those associated with conventional chemotherapy. It is important to identify the risk factors that facilitate infections associated with bortezomib therapy. In the present report, we sought to (1) define the ...

    journal_title:Cell biochemistry and biophysics

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12013-014-0224-x

    authors: Li J,Li Y,Huang B,Zheng D,Chen M,Zhou Z

    更新日期:2015-01-01 00:00:00

  • Phospholipid distribution around the plasma membrane calcium pump: a hydrophobic photolabeling study.

    abstract::The functions of membrane proteins are highly dependent on their phospholipid environment. In this article, we have used a hydrophobic photolabeling method to study the noncovalent interactions between plasma membrane calcium pump (PMCA) and surrounding phospholipids. With this approach, we determined (1) the number o...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1385/cbb:44:3:431

    authors: Villamil Giraldo AM,Castello PR,González Flecha FL,Delfino JM,Rossi JP

    更新日期:2006-01-01 00:00:00

  • A Controlled Study of Alprostadil Liposomal Preparation in the Treatment of Blue Toe Syndrome.

    abstract::The aim of this study is to examine the efficacy of alprostadil liposomal preparation in the treatment of blue toe syndrome. As many as 32 patients with blue toe syndrome were randomized into the test group and a control group. Patients out of the test group were treated with alprostadil liposomal preparation, while t...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s12013-014-0448-9

    authors: Xi HL,Li R,Tian ZL,Feng S,Jia GL

    更新日期:2015-05-01 00:00:00

  • Therapeutical effects and mechanism of salubrinal combined with ulinastatin on treating paraquat poisoning.

    abstract::To explore therapeutic effects and underlying mechanism of Salubrinal combined with Ulinastatin (UTI) on acute Paraquat (PQ) poisoning. Four hundred rats were randomly allocated into UTI group, SAL group, SAL + UTI and control group according to random number table with 100 rats in each group. Acute PQ poisoning model...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-014-0095-1

    authors: Guo H,Jiang C,Sun X

    更新日期:2014-12-01 00:00:00

  • Redox buffer capacity of the cell: theoretical and experimental approach.

    abstract::Reactive oxygen species (ROS) are involved in a variety of biological phenomena, such as mutation, carcinogenesis, inflammation, aging, development, and signal transduction. Intracellular generation of ROS might lead to the activation of redox signaling or oxidative stress. Nonetheless, it is difficult to estimate whe...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-010-9090-3

    authors: Martinovich GG,Martinovich IV,Cherenkevich SN,Sauer H

    更新日期:2010-11-01 00:00:00

  • Chromosome analysis using spectral karyotyping (SKY).

    abstract::Spectral karyotyping is a novel technique for chromosome analysis that has been developed based on the approach of the fluorescence in situ hybridization technique. Spectral karyotyping makes it feasible to diagnose a variety of diseases, because of its technology in painting each of the 24 human chromosomes with diff...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,评审

    doi:10.1007/s12013-011-9285-2

    authors: Imataka G,Arisaka O

    更新日期:2012-01-01 00:00:00

  • Nursing research on a first aid model of double personnel for major burn patients.

    abstract::This study explored the effect of a first aid model employing two nurses on the efficient rescue operation time and the efficient resuscitation time for major burn patients. A two-nurse model of first aid was designed for major burn patients. The model includes a division of labor between the first aid nurses and the ...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-014-0306-9

    authors: Wu W,Shi K,Jin Z,Liu S,Cai D,Zhao J,Chi C,Yu J

    更新日期:2015-03-01 00:00:00

  • Identifying the Interaction of Vancomycin With Novel pH-Responsive Lipids as Antibacterial Biomaterials Via Accelerated Molecular Dynamics and Binding Free Energy Calculations.

    abstract::Nano-drug delivery systems have proven to be an efficient formulation tool to overcome the challenges with current antibiotics therapy and resistance. A series of pH-responsive lipid molecules were designed and synthesized for future liposomal formulation as a nano-drug delivery system for vancomycin at the infection ...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-017-0786-5

    authors: Ahmed S,Vepuri SB,Jadhav M,Kalhapure RS,Govender T

    更新日期:2018-06-01 00:00:00

  • Interaction between umami peptide and taste receptor T1R1/T1R3.

    abstract::The umami taste receptor is a heterodimer composed of two members of the T1R taste receptor family: T1R1 and T1R3. The homology models of the ligand binding domains of the human umami receptor have been constructed based on crystallographic structures of the taste receptor of the central nervous system. Furthermore, t...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-014-0141-z

    authors: Dang Y,Gao X,Xie A,Wu X,Ma F

    更新日期:2014-12-01 00:00:00

  • CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway.

    abstract::Chloride intracellular channel 1 (CLIC1) is a sensor of oxidative stress in endothelial cells (EC). However, the mechanism by which CLIC1 mediate the regulation of endothelial dysfunction has not been established. In this study, overexpressed CLIC1 impaired the ability of the vascular cells to resist oxidative damage ...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-020-00959-6

    authors: Lu D,Le Y,Ding J,Dou X,Mao W,Zhu J

    更新日期:2021-01-11 00:00:00

  • Suitable depth of epidural puncture in nulliparous pregnant woman.

    abstract::We study the suitable depth for epidural puncture in primiparas so as to decrease epidural complications and provide anesthesiologists with an appropriate insertion guide. A prospective study of 87 primipara patients receiving labor analgesia who had epidural punctures in the course of vaginal delivery were randomly d...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-014-0277-x

    authors: Luo Y,Zhang D,Zheng J,Yang Q,An X,Chen Y,Yu D,Yang Z

    更新日期:2015-03-01 00:00:00

  • Identification of unknown homeopathic remedies by delayed luminescence.

    abstract::A quality control method of highly diluted and potentized homeopathic remedies is important for curing patients applying homeopathic therapy. Lenger detected photons in highly potentized homeopathic remedies by delayed luminescence. The photons of Argentum metallicum 100MK and Cantharis 100MK magnetically bound to the...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-013-9712-7

    authors: Lenger K,Bajpai RP,Spielmann M

    更新日期:2014-03-01 00:00:00

  • Hemodiafiltration combined with resin-mediated absorption as a therapy for hyperlipidemic acute pancreatitis.

    abstract::The aim of this study is to investigate whether hemodiafiltration combined with resin-mediated absorption is a better therapy for hyperlipidemic acute pancreatitis. Patients (n = 67) with acute pancreatitis treated in ICU from January 2009 to December 2012 were included in this study. Seven of these 67 cases were diag...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-014-9855-1

    authors: Li MQ,Shi ZX,Xu JY,Lu B,Li JQ,Xu YJ,Wang XM,Li SM,Mo X

    更新日期:2014-07-01 00:00:00

  • CT diagnosis in the thecoma-fibroma group of the ovarian stromal tumors.

    abstract::The aim of this study was to investigate characteristic CT manifestations of the group of ovarian thecoma-fibroma. 24 patients (26 lesions) presenting with the ovarian thecoma-fibroma were analyzed retrospectively, and the diagnosis were confirmed by pathology after surgery. Our findings included: 22 patients were uni...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-014-0288-7

    authors: Zhang Z,Wu Y,Gao J

    更新日期:2015-03-01 00:00:00

  • Regulation of the NPT gene by a naturally occurring antisense transcript.

    abstract::The epithelial Na/Pi cotransporter (NaPi-II) is instrumental in maintaining phosphate (Pi) homeostasis in vertebrates. Hormones and metabolic factors (PTH, Pi availability) that acutely influence renal Pi excretion have been demonstrated to target NaPi-II expression. Upon stimulation, newly synthesized transporter mol...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,评审

    doi:10.1385/CBB:36:2-3:241

    authors: Werner A,Preston-Fayers K,Dehmelt L,Nalbant P

    更新日期:2002-01-01 00:00:00

  • Determination of concentration of methotrexate enantiomers in intracellular and extracellular fluids of HepG2 cells by liquid chromatography-tandem mass spectrometry.

    abstract::A rapid and sensitive liquid chromatography-tandem mass spectrometry assay (LC-MS/MS) with electrospray ionization was developed and validated for the quantitative determination of the concentration of methotrexate (MTX) enantiomers in intracellular and extracellular fluids of HepG2 cells. The analytes were extracted ...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-013-9666-9

    authors: Wang R,Guo L,Xie H,Zhang J,Li X,Li W,Wang J,Wu X,Jia Z

    更新日期:2013-01-01 00:00:00

  • Insulin signaling and glucose transport in insulin resistant human skeletal muscle.

    abstract::Insulin increases glucose uptake and metabolism in skeletal muscle by signal transduction via protein phosphorylation cascades. Insulin action on signal transduction is impaired in skeletal muscle from Type 2 diabetic subjects, underscoring the contribution of molecular defects to the insulin resistant phenotype. This...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,评审

    doi:10.1007/s12013-007-0030-9

    authors: Karlsson HK,Zierath JR

    更新日期:2007-01-01 00:00:00

  • Determination of DNA damage in experimental liver intoxication and role of N-acetyl cysteine.

    abstract::The present study aimed at detecting DNA damage and fragmentation as well as histone acetylation depending on oxidative stress caused by CCl4 intoxication. Also, the protective role of N-acetyl cysteine, a precursor for GSH, in DNA damage is investigated. Sixty rats were used in this study. In order to induce liver to...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-014-0031-4

    authors: Aksit H,Bildik A

    更新日期:2014-11-01 00:00:00

  • Novel c.2216T > C (p.I739T) mutation in exon 13 and c.1481T > A (p.L494X) mutation in exon 8 of MUT gene in a female with methylmalonic acidemia.

    abstract::We report herein a 1.5-year-old girl with methylmalonic acidemia (MMA) in whom two missense mutations were found: a novel I739T mutation located in exon 13 and the L494X mutation in exon 8. The results of organic acid test showed a pronounced increase in methylmalonate excretion with increased methylcitrate and 3-OH-p...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1007/s12013-013-9532-9

    authors: Imataka G,Sakamoto O,Yamanouchi H,Yoshihara S,Omura-Hasegawa Y,Tajima G,Arisaka O

    更新日期:2013-09-01 00:00:00