Insulin signaling and glucose transport in insulin resistant human skeletal muscle.

Abstract:

:Insulin increases glucose uptake and metabolism in skeletal muscle by signal transduction via protein phosphorylation cascades. Insulin action on signal transduction is impaired in skeletal muscle from Type 2 diabetic subjects, underscoring the contribution of molecular defects to the insulin resistant phenotype. This review summarizes recent work to identify downstream intermediates in the insulin signaling pathways governing glucose homeostasis, in an attempt to characterize the molecular mechanism accounting for skeletal muscle insulin resistance in Type 2 diabetes. Furthermore, the effects of pharmaceutical treatment of Type 2 diabetic patients on insulin signaling and glucose uptake are discussed. The identification and characterization of pathways governing insulin action on glucose metabolism will facilitate the development of strategies to improve insulin sensitivity in an effort to prevent and treat Type 2 diabetes mellitus.

journal_name

Cell Biochem Biophys

authors

Karlsson HK,Zierath JR

doi

10.1007/s12013-007-0030-9

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

103-13

issue

2-3

eissn

1085-9195

issn

1559-0283

pii

CBB:48:2-3:103

journal_volume

48

pub_type

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