Abstract:
:Insulin increases glucose uptake and metabolism in skeletal muscle by signal transduction via protein phosphorylation cascades. Insulin action on signal transduction is impaired in skeletal muscle from Type 2 diabetic subjects, underscoring the contribution of molecular defects to the insulin resistant phenotype. This review summarizes recent work to identify downstream intermediates in the insulin signaling pathways governing glucose homeostasis, in an attempt to characterize the molecular mechanism accounting for skeletal muscle insulin resistance in Type 2 diabetes. Furthermore, the effects of pharmaceutical treatment of Type 2 diabetic patients on insulin signaling and glucose uptake are discussed. The identification and characterization of pathways governing insulin action on glucose metabolism will facilitate the development of strategies to improve insulin sensitivity in an effort to prevent and treat Type 2 diabetes mellitus.
journal_name
Cell Biochem Biophysjournal_title
Cell biochemistry and biophysicsauthors
Karlsson HK,Zierath JRdoi
10.1007/s12013-007-0030-9subject
Has Abstractpub_date
2007-01-01 00:00:00pages
103-13issue
2-3eissn
1085-9195issn
1559-0283pii
CBB:48:2-3:103journal_volume
48pub_type
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