当前位置： SCI文献检索 > CELL BIOCHEMISTRY AND BIOPHYSICS期刊下所有文献 > Association with leptin gene C.-2548 G>A polymorphism, serum leptin levels, and body mass index in Turkish obese patients.

Association with leptin gene C.-2548 G>A polymorphism, serum leptin levels, and body mass index in Turkish obese patients.

Abstract：

:Leptin is a protein hormone which plays a critical role in the regulation of both body-weight through reducing food intake and stimulating energy expenditure. Several polymorphisms in leptin gene (LEP), which encodes for leptin, have been described. However, its association with obesity is still controversial. Therefore, in the present study, we aimed to investigate whether LEP c.-2548 G>A polymorphism was associated with serum leptin levels, lipid parameters, and body mass index in Turkish obese patients. Forty-seven obese patients and 48 healthy individuals were included in the study. Blood samples were collected for DNA extraction. LEP c.-2548 G>A polymorphism were detected using polymerase chain reaction-restriction fragment length polymorphism technique. Serum leptin levels and lipid parameters were measured by ELISA and enzyme colorimetric assay techniques, respectively. GA or AA genotypes and A allele carrier frequencies of the c.-2548 G>A polymorphism in the LEP were higher in obese (38.3, 34.0 and 72.3 %) when compared with controls (14.6, 12.5, and 27.1 %; p = 0.011, 0.016, and 0.002, respectively). On the other hand, AA or AG genotypes were also related to increased serum leptin levels (p < 0.001) and body mass index (p < 0.0001). All these consequences showed that LEP -2548 AA or AG genotypes are important predictors for increased levels of leptin and BMI in Turkish obese patients and it may be a useful marker for obesity risk in our population.

journal_name

Cell Biochem Biophys

journal_title

Cell biochemistry and biophysics

authors

Sahin DS,Tumer C,Demir C,Celik MM,Celik M,Ucar E,Gunesacar R

doi

10.1007/s12013-012-9427-1

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

243-7

issue

2

eissn

1085-9195

issn

1559-0283

journal_volume

65

pub_type

杂志文章

相关文献

CELL BIOCHEMISTRY AND BIOPHYSICS文献大全
  • Ecto-mesenchymal stem cells from facial process: potential for muscle regeneration.

    abstract：:Ecto-mesenchymal stem cells (EMSCs) originate from the cranial neural crest and participate in the formation of tooth, salivary, and muscle in early development stage. The transplantation of EMSCs, a potential source of myoblast stem cell, might improve muscle regeneration. The purpose of this study was to explore whe...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-014-9964-x

    authors： Nie X,Xing Y,Deng M,Gang L,Liu R,Zhang Y,Wen X

    更新日期：2014-09-01 00:00:00

  • Identification and characterization of a proteolysis-resistant fragment containing the PCI domain in the Arabidopsis thaliana INT6/eIF3e translation factor.

    abstract：:The PCI domain comprises approx 200 amino acids and is found in subunits of the eukaryotic translation initiation factor 3 (eIF3), the 26S proteasome and the COP9/signalosome complexes. The PCI domain is involved in protein-protein interaction, and mouse INT6 truncated proteins lacking the PCI domain show cell maligna...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1385/CBB:44:3:522

    authors： Murai MJ,Carneiro FR,Gozzo FC,Ierardi DF,Pertinhez TA,Zanchin NI

    更新日期：2006-01-01 00:00:00

  • Effects of Phyllanthus sellowianus Müll Arg. extracts on the rheological properties of human erythrocytes.

    abstract：:Phyllanthus sellowianus extracts have been used in Argentina since colonial times in the treatment of diabetes. The in vitro biorheological and hemoagglutinant action of different extracts of P. sellowianus bark on human erythrocytes (RBC) were studied. RBCs were incubated in vitro with four aqueous extracts: Macerati...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-014-0072-8

    authors： Buszniez P,Di Sapio O,Riquelme B

    更新日期：2014-11-01 00:00:00

  • Differentiation of reprogrammed mouse cardiac fibroblasts into functional cardiomyocytes.

    abstract：:Fibroblasts can be reprogrammed by ectopic expression of reprogramming factors to yield induced pluripotent stem (iPS) cells that are capable of transdifferentiating into diverse types of somatic cell lines. In this study, we examined if functional cardiomyocytes (CMs) can be produced from mouse cardiac fibroblasts (C...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-012-9487-2

    authors： Jiang B,Dong H,Li Q,Yu Y,Zhang Z,Zhang Y,Wang G,Zhang Z

    更新日期：2013-06-01 00:00:00

  • Effect of bone morphogenetic protein 4 in the human brain glioma cell line U251.

    abstract：:The role of bone morphogenetic protein 4 (BMP4) in gliomas is not clear. We hypothesized that BMP4 inhibits proliferation in the brain glioma cell line U251 through a signaling pathway involving BMP4 and the mothers against decapentaplegic homolog 4 (SMAD4) protein. We exposed U251 cells to Adriamycin (1 g) for 48 h; ...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-010-9095-y

    authors： Liu B,Tian D,Yi W,Wu L,Cai Q,Dong H,Shen H,Ji B,Wang L,Zhang S,Ruan D,Chen Q

    更新日期：2010-11-01 00:00:00

  • Highly Conserved Arg Residue of ERFNIN Motif of Pro-Domain is Important for pH-Induced Zymogen Activation Process in Cysteine Cathepsins K and L.

    abstract：:Pro-domain of a cysteine cathepsin contains a highly conserved Ex2Rx2Fx2Nx3Ix3N (ERFNIN) motif. The zymogen structure of cathepsins revealed that the Arg(R) residue of the motif is a central residue of a salt-bridge/H-bond network, stabilizing the scaffold of the pro-domain. Importance of the arginine is also demonstr...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-017-0838-x

    authors： Aich P,Biswas S

    更新日期：2018-06-01 00:00:00

  • Infections Related to Totally Implantable Venous-Access Ports: Long-Term Experience in One Center.

    abstract：:The purpose of this study was to investigate the incidence and risk factors of infections associated with totally implantable venous-access ports (TIVAPs) in our hospital. From April 2007 through November 2013, a total of 1,026 patients with TIVAP were included in this study. We retrospectively analyzed the incidence ...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-014-0443-1

    authors： Ji L,Yang J,Miao J,Shao Q,Cao Y,Li H

    更新日期：2015-05-01 00:00:00

  • Genetic evaluation of peroxisomal and cytosolic acetoacetyl-CoA thiolase isozymes in n-alkane-assimilating diploid yeast, Candida tropicalis.

    abstract：:The n-alkane-assimilating diploid yeast, Candida tropicalis, possesses two acetoacetyl-CoA thiolase (Thiolase I) isozymes encoded by one allele: peroxisomal and cytosolic Thiolase Is encoded by both CT-T1A and CT-T1B. To clarify the function of peroxisomal and cytosolic Thiolase Is, the site-directed mutation leading ...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1385/cbb:32:1-3:285

    authors： Ueda M,Kanayama N,Tanaka A

    更新日期：2000-01-01 00:00:00

  • Measuring activity in the ubiquitin-proteasome system: from large scale discoveries to single cells analysis.

    abstract：:The ubiquitin-proteasome system (UPS) is the primary pathway responsible for the recognition and degradation of misfolded, damaged, or tightly regulated proteins in addition to performing essential roles in DNA repair, cell cycle regulation, cell migration, and the immune response. While traditional biochemical techni...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章,评审

    doi：10.1007/s12013-013-9621-9

    authors： Melvin AT,Woss GS,Park JH,Waters ML,Allbritton NL

    更新日期：2013-09-01 00:00:00

  • MT2A Promotes Oxaliplatin Resistance in Colorectal Cancer Cells.

    abstract：:We aimed to understand the molecular mechanism underlying the incidence of Oxaliplatin resistance in colorectal cancer. The Oxaliplatin-resistant (OR) HT29 colorectal cell line was established by long-term exposure to Oxaliplatin. Cell viability and proliferation were determined by the 3-(4,5-dimethyl thiazol-2-yl)-2,...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-020-00930-5

    authors： Zhao Z,Zhang G,Li W

    更新日期：2020-12-01 00:00:00

  • Fluorescence spectroscopy of single photosynthetic light-harvesting supramolecular systems.

    abstract：:Recent spectroscopic studies of photosynthetic light-harvesting supramolecular complexes at the single supramolecule level are reviewed. This report describes the "single-molecule" investigation on light-harvesting complex 2 (LH2) of purple photosynthetic bacteria, phycobiliproteins of cyanobacteria and red algae, lig...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章,评审

    doi：10.1385/CBB:40:2:149

    authors： Saga Y,Tamiaki H

    更新日期：2004-01-01 00:00:00

  • Applicability of different endovascular methods for treatment of refractory Budd-Chiari syndrome.

    abstract：:The study's objective was to evaluate the applicability of different endovascular methods for treatment of refractory type of Budd-Chiari syndrome (BCS) under specific scenarios frequently encountered in patients. The treatment methods were evaluated in 197 patients with the following four types of refractory BCS: les...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-011-9211-7

    authors： Gao Y,Chen S,Yu C

    更新日期：2011-11-01 00:00:00

  • Single Active Site Mutation Causes Serious Resistance of HIV Reverse Transcriptase to Lamivudine: Insight from Multiple Molecular Dynamics Simulations.

    abstract：:Molecular dynamics simulations, binding free energy calculations, principle component analysis (PCA), and residue interaction network analysis were employed in order to investigate the molecular mechanism of M184I single mutation which played pivotal role in making the HIV-1 reverse transcriptase (RT) totally resistan...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-015-0709-2

    authors： Moonsamy S,Bhakat S,Walker RC,Soliman ME

    更新日期：2016-03-01 00:00:00

  • Biorheological action of Ascaris lumbricoides larvae on human erythrocytes.

    abstract：:Previous studies have shown that A. lumbricoides extracts capture sialic acid (SA) from human red blood cells (RBC). The aim of this work was to study hemorheological alterations in vitro caused by parasite larvae. The biorheological action of three larva concentrates of first and second larval stage on group O erythr...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-012-9425-3

    authors： de León PP,Del Balzo G,Riquelme B

    更新日期：2013-03-01 00:00:00

  • Human Salivary Aldehyde Dehydrogenase: Purification, Kinetic Characterization and Effect of Ethanol, Hydrogen Peroxide and Sodium Dodecyl Sulfate on the Activity of the Enzyme.

    abstract：:Human salivary aldehyde dehydrogenase (hsALDH) enzyme appears to be the first line of defense in the body against exogenous toxic aldehydes. However till date much work has not been done on this important member of the ALDH family. In this study, we have purified hsALDH to homogeneity by diethylaminoethyl-cellulose (D...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-016-0742-9

    authors： Alam MF,Laskar AA,Choudhary HH,Younus H

    更新日期：2016-09-01 00:00:00

  • Tirofiban Combined with Fondaparinux for Post-PCI Treatment of Patients with Acute Coronary Syndrome and Mild Renal Insufficiency.

    abstract：:Proper administration of antithrombotic and antiplatelet drugs after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) and renal insufficiency is a challenging task. In this study, we utilized Fondaparinux and Tirofiban (either separately or combined) to treat post-PCI patients wi...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s12013-015-0580-1

    authors： Changjiang H,Jian Q,Yuan Z,Liang Y,Puqing L,Xiaolong G

    更新日期：2015-12-01 00:00:00

  • Quercetin potentiates the antitumor activity of rituximab in diffuse large B-cell lymphoma by inhibiting STAT3 pathway.

    abstract：:STAT3 pathway plays an important role in the growth of diffuse large B-cell lymphoma (DLBCL) cells. Here we investigated the antitumor activity of Quercetin, a flavonoid compound, in combination with rituximab in DLBCL cell lines in vitro. We found that Quercetin synergistically enhanced rituximab-induced growth inhib...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-014-0064-8

    authors： Li X,Wang X,Zhang M,Li A,Sun Z,Yu Q

    更新日期：2014-11-01 00:00:00

  • An observational study of autologous bone marrow-derived stem cells transplantation in seven patients with nervous system diseases: a 2-year follow-up.

    abstract：:Currently, autologous bone marrow-derived stem cell is one of the most innovative areas of stem cells research. Previous studies on animal models of nervous system diseases have shown that these cells have a good effect on nervous system disorders. The alternative treatment with stem cells for the nervous system disea...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-013-9756-8

    authors： Ren C,Geng RL,Ge W,Liu XY,Chen H,Wan MR,Geng DQ

    更新日期：2014-05-01 00:00:00

  • Estimation of Some Oxidative Stress Parameters and Blood Pressure After Administration of Endothelin-1 (ET-1) in Rats.

    abstract：:The aim of the study was to investigate changes in the plasma antioxidative activity and in lipid peroxidation after administration of endothelin-1 (ET-1) and endothelin receptor blockers and additionally, to estimate blood pressure. The study was performed on male Wistar rats (n = 6 per group) divided into 4 groups w...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-014-0371-0

    authors： Kleniewska P,Kowalczyk A,Ciesla W,Goraca A

    更新日期：2015-04-01 00:00:00

  • A possible role of Aspergillus niger mitochondrial cytochrome c in malachite green reduction under calcium chloride stress.

    abstract：:In previous work, decolorization of malachite green (MG) was studied in Aspergillus niger in the presence and absence of calcium chloride stress. Decolorization took place within 24 h, and a signal transduction process that initiated MG decolorization was suggested to be involved. In the present study, further investi...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-013-9661-1

    authors： Gomaa OM,Selim NS,Linz JE

    更新日期：2013-01-01 00:00:00

  • Screening of Inherited Metabolic Disorders in Infants with Infantile Spasms.

    abstract：:The objective of this study is to explore the incidence of inherited metabolic disorders (IMD) in infants with infantile spasms (IS), with an attempt to improve the early diagnosis and etiological and symptomatic treatment. Urine and blood samples were collected from 60 IS patients and analyzed for the quantification ...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-014-0404-8

    authors： Liu XM,Li R,Chen SZ,Sang Y,Chen J,Fan CH

    更新日期：2015-05-01 00:00:00

  • CT diagnosis in the thecoma-fibroma group of the ovarian stromal tumors.

    abstract：:The aim of this study was to investigate characteristic CT manifestations of the group of ovarian thecoma-fibroma. 24 patients (26 lesions) presenting with the ovarian thecoma-fibroma were analyzed retrospectively, and the diagnosis were confirmed by pathology after surgery. Our findings included: 22 patients were uni...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-014-0288-7

    authors： Zhang Z,Wu Y,Gao J

    更新日期：2015-03-01 00:00:00

  • Regulation of steroid receptor subcellular trafficking.

    abstract：:Cellular responses to external signals often reflect alterations in gene expression. The activation of cell surface hormone or growth factor receptors upon the binding of appropriate ligands mobilizes signal transduction cascades that can ultimately impact the activity of defined sets of transcription factors. The int...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章,评审

    doi：10.1007/BF02737882

    authors： DeFranco DB

    更新日期：1999-01-01 00:00:00

  • Introducing a New Model of Sweet Taste Receptor, a Class C G-protein Coupled Receptor (C GPCR).

    abstract：:The structure of sweet taste receptor (STR), a heterodimer of class C G-protein coupled receptors comprising T1R2 and T1R3 molecules, is still undetermined. In this study, a new enhanced model of the receptor is introduced based on the most recent templates. The improvement, stability, and reliability of the model are...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-019-00872-7

    authors： Kashani-Amin E,Sakhteman A,Larijani B,Ebrahim-Habibi A

    更新日期：2019-09-01 00:00:00

  • Vascularized composite islet-kidney transplantation in a miniature swine model.

    abstract：:Previous work from this laboratory has demonstrated that transplantation of allogeneic thymic tissue as part of a composite vascularized graft is far more successful in terms of both engraftment and long-term survival than transplantation of thymic tissue or cells alone. We have subsequently extended this concept to t...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章,评审

    doi：10.1007/s12013-007-0027-4

    authors： Vallabhajosyula P,Griesemer A,Yamada K,Sachs DH

    更新日期：2007-01-01 00:00:00

  • Quantitative assessment of the association between HDMX polymorphism and sarcoma.

    abstract：:To investigate the effects of the HDMX polymorphism on sarcoma risk. Relevant studies were identified by searching the PubMed, Embase, and Web of Science databases. Data were extracted by two independent investigators. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated using a fixed-effects model to...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章,meta分析

    doi：10.1007/s12013-014-0111-5

    authors： Xu H,Zhou P,Ti Y,Jia F

    更新日期：2014-12-01 00:00:00

  • Electrocardiogram for predicting cardiac functional recovery.

    abstract：:To investigate if the 12-lead resting electrocardiogram (ECG) is a predictor of left ventricular (LV) functional recovery after revascularization of chronic total coronary artery occlusions (CTO). Revascularization was performed in 58 CTO patients who had impaired regional wall motion. The 12-lead resting ECG was used...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-014-9862-2

    authors： Yue W,Wang G,Zhang X,Chen B,Wang X,Huangfu F,Jia R

    更新日期：2014-09-01 00:00:00

  • Nursing research on a first aid model of double personnel for major burn patients.

    abstract：:This study explored the effect of a first aid model employing two nurses on the efficient rescue operation time and the efficient resuscitation time for major burn patients. A two-nurse model of first aid was designed for major burn patients. The model includes a division of labor between the first aid nurses and the ...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-014-0306-9

    authors： Wu W,Shi K,Jin Z,Liu S,Cai D,Zhao J,Chi C,Yu J

    更新日期：2015-03-01 00:00:00

  • Surfactin induces apoptosis and G(2)/M arrest in human breast cancer MCF-7 cells through cell cycle factor regulation.

    abstract：:Surfactin, purified from Bacillus subtilis natto TK-1, inhibited proliferation of human breast cancer MCF-7 cells in a dose- and time-dependent manner, with IC(50) at 24, 48, and 72 h of 82.6, 27.3, and 14.8 microM, respectively. Surfactin-induced cell death was considered to be apoptotic by observing the typical apop...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-009-9065-4

    authors： Cao X,Wang AH,Jiao RZ,Wang CL,Mao DZ,Yan L,Zeng B

    更新日期：2009-01-01 00:00:00

  • Comparison Between Sporadic and Misdiagnosed Sporadic Creutzfeldt-Jakob Disease: A Report of Two Cases.

    abstract：:Definite accurate diagnosis for Creutzfeldt-Jakob disease (CJD) depends on neuropathologic examination of brain biopsy or autopsy. However, transmissible nature makes the invasive examination dangerous. This study was set to determine that the clinical features are for the diagnosis of CJD through a comparison study. ...

    journal_title：Cell biochemistry and biophysics

    pub_type： 杂志文章

    doi：10.1007/s12013-014-0458-7

    authors： Zhao X,Yu Y,Zhao Z,Xu J

    更新日期：2015-06-01 00:00:00