Abstract:
:Ecto-mesenchymal stem cells (EMSCs) originate from the cranial neural crest and participate in the formation of tooth, salivary, and muscle in early development stage. The transplantation of EMSCs, a potential source of myoblast stem cell, might improve muscle regeneration. The purpose of this study was to explore whether EMSCs have the potential to differentiate and display a myogenic phenotype in vitro the in vitro. Here, we characterized the EMSCs isolated from the facial process, and p75 + EMSCs were collected by a FACS calibur flow cytometer. In vitro, p75 + EMSCs induced by DMSO can accumulate and fuse into multinucleated myotubes and further differentiate into the skeletal muscle cells in form of cell sheet. Functional myoblast phenotypes of p75 + EMSCs were found in vivo model of muscle injury. The remarkable ability of stem cells to regenerate skeletal muscle indicated their potential role in the cell therapy and tissue engineering of the skeletal muscle.
journal_name
Cell Biochem Biophysjournal_title
Cell biochemistry and biophysicsauthors
Nie X,Xing Y,Deng M,Gang L,Liu R,Zhang Y,Wen Xdoi
10.1007/s12013-014-9964-xsubject
Has Abstractpub_date
2014-09-01 00:00:00pages
615-22issue
1eissn
1085-9195issn
1559-0283journal_volume
70pub_type
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