Abstract:
:Skin fibrosis is one of the major features of scleroderma. WNT/β-catenin signaling is associated with the progression of skin fibrosis. In this study, we aimed to determine the effect of icaritin (IT), a natural compound, on scleroderma-related skin fibrosis and its mechanisms. We found that IT could reduce the expression of COL1A1, COL1A2, COL3A1, CTGF, and α-SMA in human foreskin fibroblasts (HFF-1 cells), scleroderma skin fibroblasts (SSF cells), and TGF-β-induced HFF-1 cells. Wnt/β-catenin signaling was shown to be suppressed by IT. Additionally, IT activated AMPK signaling in HFF-1 cells. In conclusion, IT has an anti-skin fibrotic effect through activation of AMPK signaling and inhibition of WNT/β-catenin signaling. Our findings indicate the potential role of IT in the treatment of scleroderma and provide novel insight for the selection of drug therapy for scleroderma.
journal_name
Cell Biochem Biophysjournal_title
Cell biochemistry and biophysicsauthors
Li M,Liu Q,He S,Kong X,Lin J,Huang Y,Wu W,Wu Jdoi
10.1007/s12013-020-00952-zsubject
Has Abstractpub_date
2020-10-30 00:00:00eissn
1085-9195issn
1559-0283pii
10.1007/s12013-020-00952-zpub_type
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