(Pro)Insulin processing: a historical perspective.

Abstract:

:Insulin, the major secreted product of the beta-cells of the islets of Langerhans, is initially synthesized as a precursor (preproinsulin), from which the mature hormone is excised by a series of proteolytic cleavages. This review provides a personal narrative of some of the key research projects leading to the identification of the central processing enzymes as proprotein convertase 1, proprotein convertase 2, and carboxypeptidase E. It also discusses the central roles of the intragranular environment and chaperone-like proteins in modulating processing activity.

journal_name

Cell Biochem Biophys

authors

Davidson HW

doi

10.1385/cbb:40:3:143

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

143-58

issue

3 Suppl

eissn

1085-9195

issn

1559-0283

pii

CBB:40:3S:143

journal_volume

40

pub_type

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