(Pro)Insulin processing: a historical perspective.

abstract：:The bis-retinoid N-retinyl-N-retinylidene ethanolamine (A2E) is formed as a byproduct of visual cycle in retinal pigment epithelium (RPE). It contributes to golden-yellow fluorescence of the age pigment lipofuscin, which accumulates in RPE. Lipofuscin can generate a variety of reactive oxygen species (ROS) upon blue-l...

journal_title：Cell biochemistry and biophysics

authors： Furso J,Zadlo A,Szewczyk G,Sarna TJ

更新日期：2020-12-01 00:00:00

abstract：:To examine the antiproliferative effect of the combination of docetaxel and sorafenib, applied to the representative non-small cell lung cancer cell line A549 cells either wild type or with acquired resistance to docetaxel (A549/D). The aim of this study is to evaluate the synergistic effect of combination treatment o...

journal_title：Cell biochemistry and biophysics

authors： He X,Zhang T

更新日期：2014-03-01 00:00:00

abstract：:The peritoneal mesothelium acts as a regulator of serosal responses to injury, infection, and neoplastic diseases. After inflammation of the serosal surfaces, proinflammatory cytokines induce an "activated" mesothelial cell phenotype, the mitochondrial aspect of which has not previously been studied. After incubation ...

journal_title：Cell biochemistry and biophysics

authors： Stadlmann S,Renner K,Pollheimer J,Moser PL,Zeimet AG,Offner FA,Gnaiger E

更新日期：2006-01-01 00:00:00

abstract：:The objective of this study was to evaluate the protective effect of recombinant human brain natriuretic peptide (rhBNP) on endotoxin-induced acute kidney injury (AKI) in canine model of septic shock and its potential mechanisms. Dogs with endotoxin-induced septic shock were subjected to intravenous infusion of saline...

journal_title：Cell biochemistry and biophysics

authors： Li N,Jin HX,Song Z,Bai CZ,Cui Y,Gao Y

更新日期：2014-11-01 00:00:00

abstract：:STAT3 pathway plays an important role in the growth of diffuse large B-cell lymphoma (DLBCL) cells. Here we investigated the antitumor activity of Quercetin, a flavonoid compound, in combination with rituximab in DLBCL cell lines in vitro. We found that Quercetin synergistically enhanced rituximab-induced growth inhib...

journal_title：Cell biochemistry and biophysics

authors： Li X,Wang X,Zhang M,Li A,Sun Z,Yu Q

更新日期：2014-11-01 00:00:00

abstract：:Chloride intracellular channel 1 (CLIC1) is a sensor of oxidative stress in endothelial cells (EC). However, the mechanism by which CLIC1 mediate the regulation of endothelial dysfunction has not been established. In this study, overexpressed CLIC1 impaired the ability of the vascular cells to resist oxidative damage ...

journal_title：Cell biochemistry and biophysics

authors： Lu D,Le Y,Ding J,Dou X,Mao W,Zhu J

更新日期：2021-01-11 00:00:00

abstract：:Reactive oxygen species (ROS) are involved in a variety of biological phenomena, such as mutation, carcinogenesis, inflammation, aging, development, and signal transduction. Intracellular generation of ROS might lead to the activation of redox signaling or oxidative stress. Nonetheless, it is difficult to estimate whe...

journal_title：Cell biochemistry and biophysics

authors： Martinovich GG,Martinovich IV,Cherenkevich SN,Sauer H

更新日期：2010-11-01 00:00:00

abstract：:The precise regulation of both the magnitude and the duration of Janus kinase (JAK) catalytic activity is essential for the cytokine orchestration of many biological processes, and the dysregulation of JAK activity has pathological implications. Immunosuppressive disease states, such as X-linked severe combined immuno...

journal_title：Cell biochemistry and biophysics

authors： Duhé RJ,Wang LH,Farrar WL

更新日期：2001-01-01 00:00:00

abstract：:The objective is to explore the clinical curative effects of methylprednisolone combined with MTX and DXM intrathecal injection in treating neuropsychiatric systemic lupus erythematosus (NPSLE) and its effects on autoantibody level and anti-N-methyl-D-aspartate receptor subtype NR2a/2b antibody (anti-NR2 antibody) lev...

journal_title：Cell biochemistry and biophysics

authors： Wang J,Zhao Y,Zhang J,Lei H,Zhu G,Fu B

更新日期：2014-11-01 00:00:00

abstract：:Topical application of 10-hydroxycamptothecin (HCPT) can reduce intra-articular scar adhesion after knee surgery, but the effect of HCPT on wound healing has not yet been elucidated. The study investigates the effect of the topical application of HCPT on wound healing after knee surgery in rabbits. Forty New Zealand w...

journal_title：Cell biochemistry and biophysics

authors： Yan L,Sun Y,Li X,Liang Y,Zhu G,Wang J,Xiao T

更新日期：2015-09-01 00:00:00

abstract：:Azurin, a small blue copper protein from the bacterial species Pseudomonas aeruginosa, is mostly a beta-sheet protein arranged into a single domain. Previous folding studies have shown that the equilibrium denaturation of the holoprotein follows a two-state process; however, upon removal of the copper, the denaturatio...

journal_title：Cell biochemistry and biophysics

authors： Hansen JE,McBrayer MK,Robbins M,Suh Y

更新日期：2002-01-01 00:00:00

abstract：:Tetrahydrobiopterin (BH4) is a member of the pterin family that has a core structure of pyrazino-2,3-d-pyrimidine rings. Because BH4 is an essential cofactor for the biosynthesis of nitric oxide (a major vasodilator), there is growing interest in BH4 biochemistry in endothelial cells (the cells that line blood vessels...

journal_title：Cell biochemistry and biophysics

authors： Shi W,Meininger CJ,Haynes TE,Hatakeyama K,Wu G

更新日期：2004-01-01 00:00:00

abstract：:Recent studies designed to assess the relationship between aortic compliance and heterogeneity of heart electrical activity has shown that hypertrophy aggravates repolarization disturbances in the myocardium. Numerous mechanisms of electrical instability and inhomogeneity associated with left ventricular hypertrophy a...

journal_title：Cell biochemistry and biophysics

authors： Gao C,Yang D

更新日期：2014-07-01 00:00:00

abstract：:To assess the image quality of monochromatic imaging from spectral CT in patients with Budd-Chiari syndrome (BCS), fifty patients with BCS underwent spectral CT to generate conventional 140 kVp polychromatic images (group A) and monochromatic images, with energy levels from 40 to 80, 40 + 70, and 50 + 70 keV fusion im...

journal_title：Cell biochemistry and biophysics

authors： Su L,Dong J,Sun Q,Liu J,Lv P,Hu L,Yan L,Gao J

更新日期：2014-11-01 00:00:00

abstract：:Peroxisomal and mitochondrial carnitine acetyltransferase (CAT; EC 2.3.1.7) isozymes are synthesized from the first and second ATG codons of the open reading frame of one gene, Candida tropicalis CAT. Primer extension analysis and RNase protection assay revealed that the peroxisomal CAT, initiating at the second AUG c...

journal_title：Cell biochemistry and biophysics

authors： Tanaka A,Ueda M

更新日期：2000-01-01 00:00:00

abstract：:The coherent electromagnetic radiation (EMR) of the frequency of 51.8 and 53 GHz with low intensity (the power flux density of 0.06 mW/cm(2)) affected the growth of Escherichia coli K12(lambda) under fermentation conditions: the lowering of the growth specific rate was considerably (approximately 2-fold) increased wit...

journal_title：Cell biochemistry and biophysics

authors： Tadevosyan H,Kalantaryan V,Trchounian A

更新日期：2008-01-01 00:00:00

abstract：:Red blood cell (RBC) adhesion to vessel wall endothelium is a potent catalyst of vascular occlusion and occurs in oxidative stress states such as hemoglobinopathies and cardiovascular conditions. These are often treated with vitamin E (VitE), a "classic" antioxidant. In this study, we examined the effects of VitE on R...

journal_title：Cell biochemistry and biophysics

authors： Koshkaryev A,Barshtein G,Yedgar S

更新日期：2010-04-01 00:00:00

abstract：:The present study aimed at detecting DNA damage and fragmentation as well as histone acetylation depending on oxidative stress caused by CCl4 intoxication. Also, the protective role of N-acetyl cysteine, a precursor for GSH, in DNA damage is investigated. Sixty rats were used in this study. In order to induce liver to...

journal_title：Cell biochemistry and biophysics

authors： Aksit H,Bildik A

更新日期：2014-11-01 00:00:00

abstract：:Many of the structural domains involved in Ca2+ channel (CACN) inactivation are also involved in determining their sensitivity to antagonist inhibition. We hypothesize that differences in inactivation properties and their structural determinants may suggest candidate domains as targets for the development of novel, se...

journal_title：Cell biochemistry and biophysics

authors： Cox RH,Kathrins M

更新日期：2006-01-01 00:00:00

abstract：:The CEP genes play a pivotal role in the replication of the cell. CEP family proteins form the major constituents of the centrosome and play a prominent role in centriole biogenesis and in cell replication. Alteration in CEP genes will result in disruption of cell cycle that may in turn cause cancer. In our study, we ...

journal_title：Cell biochemistry and biophysics

authors： Gopalakrishnan C,Kamaraj B,Purohit R

更新日期：2014-12-01 00:00:00

abstract：:The airways in asthma and COPD are characterized by an increase in airway smooth muscle (ASM) mass and bronchial vascular changes associated with increased expression of pro-angiogenic growth factors, such as fibroblast growth factors (FGF-1 and FGF-2) and vascular endothelial growth factor (VEGF). We investigated the...

journal_title：Cell biochemistry and biophysics

authors： Willems-Widyastuti A,Vanaudenaerde BM,Vos R,Dilisen E,Verleden SE,De Vleeschauwer SI,Vaneylen A,Mooi WJ,de Boer WI,Sharma HS,Verleden GM

更新日期：2013-11-01 00:00:00

abstract：:We identified significantly higher expression of the genes glycogen debranching enzyme 6 (AGL), enolase 1 (ENOSF1), ectonucleotide pyrophosphatase 2 (ENPP2_1), glutathione S-transferase 3 (GSTM3_3) and mannosidase (MAN2B2) from human left cerebrums versus chimpanzees. Yet the distinct low- and high-expression AGL, ENO...

journal_title：Cell biochemistry and biophysics

authors： Sun L,Wang L,Jiang M,Huang J,Lin H

更新日期：2011-12-01 00:00:00

abstract：:The purpose of the study is to evaluate the effectiveness and safety of transarterial chemoembolization (TACE) with pingyangmycin-lipiodol emulsion for the treatment of symptomatic giant hepatic haemangioma. Four hospitals (The Second Hospital of Shandong University, Qilu Hospital of Shandong University, Shandong Prov...

journal_title：Cell biochemistry and biophysics

authors： Li Y,Jia Y,Li S,Wang W,Wang Z,Wang Y,Liu B,Wang W,Chang H,Li Z

更新日期：2015-11-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) are of great interest for regenerative purposes since they are believed to aid axonal growth. With the view set on the strategies to achieve reconnection between neuronal structures, it is of great importance to characterize the behaviour of these cells on long thread-like structures...

journal_title：Cell biochemistry and biophysics

authors： Pérez-Garnés M,Martínez-Ramos C,Barcia JA,Escobar Ivirico JL,Gómez-Pinedo U,Vallés-Lluch A,Monleón Pradas M

更新日期：2013-01-01 00:00:00

abstract：:Recent studies have shown that endothelial progenitor cells (EPCs) participated in angiogenic effects of nicotine and nicotine dose dependently increased the functional activity of early EPCs. The effects of nicotine on late EPCs remain to be determined. Therefore, we investigated whether nicotine had influences on th...

journal_title：Cell biochemistry and biophysics

authors： Yu M,Li Z,Shu Z,Liu Q,Sun J,Tan X

更新日期：2014-11-01 00:00:00

abstract：:Acid-base equilibria and interfacial electrostatic properties of hydrated mesoporous and nanostructured alumina powders are determining factors for the use of these materials in heterogeneous catalysis and as a sorption media for filtration and chromatographic applications including life sciences. Here spin probe elec...

journal_title：Cell biochemistry and biophysics

authors： Kovaleva EG,Molochnikov LS,Stepanova DP,Pestov AV,Trofimov DG,Kirilyuk IA,Smirnov AI

更新日期：2017-06-01 00:00:00

abstract：:The study's objective was to evaluate the applicability of different endovascular methods for treatment of refractory type of Budd-Chiari syndrome (BCS) under specific scenarios frequently encountered in patients. The treatment methods were evaluated in 197 patients with the following four types of refractory BCS: les...

journal_title：Cell biochemistry and biophysics

authors： Gao Y,Chen S,Yu C

更新日期：2011-11-01 00:00:00

abstract：:Coronary blood flow is tightly coupled to myocardial oxygen consumption to maintain a consistently high level of myocardial oxygen extraction. This tight coupling has been proposed to depend on periarteriolar oxygen tension, signals released from cardiomyocytes (adenosine acting on K+(ATP) channels), and/or the endoth...

journal_title：Cell biochemistry and biophysics

authors： Duncker DJ,Merkus D

更新日期：2005-01-01 00:00:00

abstract：:Surfactin, purified from Bacillus subtilis natto TK-1, inhibited proliferation of human breast cancer MCF-7 cells in a dose- and time-dependent manner, with IC(50) at 24, 48, and 72 h of 82.6, 27.3, and 14.8 microM, respectively. Surfactin-induced cell death was considered to be apoptotic by observing the typical apop...

journal_title：Cell biochemistry and biophysics

authors： Cao X,Wang AH,Jiao RZ,Wang CL,Mao DZ,Yan L,Zeng B

更新日期：2009-01-01 00:00:00

abstract：:The prevalence of cardiovascular disease (CVD) is increasing dramatically especially in developing countries like India. CVD is a leading cause of morbidity and mortality. There has been a growing awareness of the role of nutrients in the prevention of CVD. One specific recommendation in the battle against CVD is the ...

journal_title：Cell biochemistry and biophysics

authors： Cao Y,Lu L,Liang J,Liu M,Li X,Sun R,Zheng Y,Zhang P

更新日期：2015-05-01 00:00:00