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Curcumin Mediates a Protective Effect Via TLR-4/NF-κB Signaling Pathway in Rat Model of Severe Acute Pancreatitis.

Abstract：

:Severe acute pancreatitis (SAP) is a common acute abdominal disease. This study was designed to investigate the preventive effects of curcumin on SAP and its possible mechanism of action. We observed increased volume of ascites, serum AMY, IL-6, and TNF-α levels, and expression of TLR-4 and NF-κB mRNA and protein in a rat model of SAP. Application of curcumin resulted in lower ascites volume and serum AMY. The levels of serum cytokines IL-10 and TNF-α were also significantly reduced after curcumin treatment, as evident from ELISA analysis. RT-PCR analysis showed down-regulation of TLR4 and NF-κB expressions as a function of curcumin treatment. Our results demonstrate the protective effect of curcumin in a rat model of SAP via the involvement of TLR-4/NF-κB signaling pathway.

journal_name

Cell Biochem Biophys

journal_title

Cell biochemistry and biophysics

authors

Zhong K

doi

10.1007/s12013-015-0664-y

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

175-80

issue

1

eissn

1085-9195

issn

1559-0283

pii

10.1007/s12013-015-0664-y

journal_volume

73

pub_type

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