Abstract:
:The elimination of viral covalently closed circular DNA (cccDNA) from the nucleus of infected hepatocytes is an obstacle to achieving sustained viral clearance during antiviral therapy of chronic hepatitis B virus (HBV) infection. The aim of our study was to determine whether treatment with siRNA is able to suppress viral cccDNA amplification using a HBV-transgenic mice model. The experimental results revealed that siRNAs can serve as efficient alternative anti-HBV agents, because they showed better inhibitory effect on viral replication and antigen expression in transgenic mice. More importantly, the siRNA markedly inhibited HBV cccDNA amplification.
journal_name
Cell Biochem Biophysjournal_title
Cell biochemistry and biophysicsauthors
Li G,Jiang G,Lu J,Chen S,Cui L,Jiao J,Wang Ydoi
10.1007/s12013-014-9847-1subject
Has Abstractpub_date
2014-07-01 00:00:00pages
649-54issue
3eissn
1085-9195issn
1559-0283journal_volume
69pub_type
杂志文章abstract::The paper focuses on the selected plant lipid issues. Classification, nomenclature, and abundance of fatty acids was discussed. Then, classification, composition, role, and organization of lipids were displayed. The involvement of lipids in xantophyll cycle and glycerolipids synthesis (as the most abundant of all lipi...
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