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Modelling the role of intrinsic electric fields in microtubules as an additional control mechanism of bi-directional intracellular transport.

Abstract：

:Active transport is essential for cellular function, while impaired transport has been linked to diseases such as neuronal degeneration. Much long distance transport in cells uses opposite polarity molecular motors of the kinesin and dynein families to move cargos along microtubules. It is clear that many types of cargo are moved by both sets of motors, and frequently in a reverse direction. The general question of how the direction of transport is regulated is still open. The mechanism of the cell's differential control of diverse cargos within the same cytoplasmic background is still unclear as is the answer to the question how endosomes and mitochondria move to different locations within the same cell. To answer these questions we postulate the existence of a local signaling mechanism used by the cell to specifically control different cargos. In particular, we propose an additional physical mechanism that works through the use of constant and alternating intrinsic (endogenous) electric fields as a means of controlling the speed and direction of microtubule-based transport. A specific model is proposed and analyzed in this paper. The model involves the rotational degrees of freedom of the C-termini of tubulin, their interactions and the coupling between elastic and dielectric degrees of freedom. Viscosity of the solution is also included and the resultant equation of motion is found as a nonlinear elliptic equation with dissipation. A particular analytical solution of this equation is obtained in the form of a kink whose properties are analyzed. It is concluded that this solution can be modulated by the presence of electric fields and hence may correspond to the observed behavior of motor protein transport along microtubules.

journal_name

Cell Biochem Biophys

journal_title

Cell biochemistry and biophysics

authors

Sataric MV,Budinski-Petkovic L,Loncarevic I,Tuszynski JA

doi

10.1007/s12013-008-9028-1

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

113-24

issue

eissn

1085-9195

issn

1559-0283

journal_volume

pub_type

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Modelling the role of intrinsic electric fields in microtubules as an additional control mechanism of bi-directional intracellular transport.