Abstract:
:The overview demonstrates how the use of only one physico-chemical approach, viz., the electron paramagnetic resonance method, allowed detection and identification of dinitrosyl iron complexes with thiol-containing ligands in various animal and bacterial cells. These complexes are formed in biological objects in the paramagnetic (electron paramagnetic resonance-active) mononuclear and diamagnetic (electron paramagnetic resonance-silent) binuclear forms and control the activity of nitrogen monoxide, one of the most universal regulators of metabolic processes in the organism. The analysis of electronic and spatial structures of dinitrosyl iron complex sheds additional light on the mechanism whereby dinitrosyl iron complex with thiol-containing ligands function in human and animal cells as donors of nitrogen monoxide and its ionized form, viz., nitrosonium ions (NO+).
journal_name
Cell Biochem Biophysjournal_title
Cell biochemistry and biophysicsauthors
Vanin AFdoi
10.1007/s12013-017-0811-8subject
Has Abstractpub_date
2018-06-01 00:00:00pages
3-17issue
1-2eissn
1085-9195issn
1559-0283pii
10.1007/s12013-017-0811-8journal_volume
76pub_type
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