Abstract:
:The divergence of protein (Hedgehog) in different organisms remains an unresolved issue to comprehend how the pathway in Hh signaling evolves. Insights into this question can help one identify the key molecules in Hh signaling. This work proposes a protein-associated factor in cells. The development of a non-reductionist theory of cellular functions in medicine is not sufficient. It is necessary to find the parameters with regards to molecules/genes that can elicit functions. This work shows that molecular interactions of gene products can be accomplished by biophysics logic. Defining the protein-associated factors in molecular activities and identifying its roles in molecular transduction are important. A misregulation in molecular switch can account for complex biomolecular consequences. This work shows the potential of the factor on homo-sapiens and unlocks its implications to gene multi-tasking functionality. The associated factor notion should facilitate the medical development in cancer therapeutics.
journal_name
Cell Biochem Biophysjournal_title
Cell biochemistry and biophysicsauthors
Sarker MM,Zhou MC,Rameshwar P,Hanover JAdoi
10.1007/s12013-013-9743-0subject
Has Abstractpub_date
2014-04-01 00:00:00pages
577-82issue
3eissn
1085-9195issn
1559-0283journal_volume
68pub_type
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