Redox buffer capacity of the cell: theoretical and experimental approach.

abstract：:It has been long known that the oncogenic extracellular environment plays an indispensable role in developing and nurturing cancer cell progression and in resistance to standard treatments. However, by how much the biophysical components of tumour extracellular environment contribute to these processes is uncertain. I...

journal_title：Cell biochemistry and biophysics

authors： Sarwar M,Sykes PH,Chitcholtan K,Evans JJ

更新日期：2021-01-12 00:00:00

abstract：:A simple analytical approximation to an inhomogeneously-broadened dispersion signal is proposed and tested with resonance lines broadened by unresolved hyperfine structure. Spectral parameters may be rapidly and accurately extracted using a nonlinear least-squares fitting algorithm. Combining the new approximation to ...

journal_title：Cell biochemistry and biophysics

authors： Bales BL

更新日期：2017-06-01 00:00:00

abstract：:The prevalence of cardiovascular disease (CVD) is increasing dramatically especially in developing countries like India. CVD is a leading cause of morbidity and mortality. There has been a growing awareness of the role of nutrients in the prevention of CVD. One specific recommendation in the battle against CVD is the ...

journal_title：Cell biochemistry and biophysics

authors： Cao Y,Lu L,Liang J,Liu M,Li X,Sun R,Zheng Y,Zhang P

更新日期：2015-05-01 00:00:00

abstract：:We apply methods from statistical physics (histograms, correlation functions, fractal dimensions, and singularity spectra) to characterize large-scale structure of the distribution of nucleotides along genomic sequences. We discuss the role of the extension of noncoding segments ("junk DNA") for the genomic organizati...

journal_title：Cell biochemistry and biophysics

authors： Oiwa NN,Goldman C

更新日期：2005-01-01 00:00:00

abstract：:Slow inactivation in voltage-gated sodium channels is a biophysical process that governs the availability of sodium channels over extended periods of time. Slow inactivation, therefore, plays an important role in controlling membrane excitability, firing properties, and spike frequency adaptation. Defective slow inact...

journal_title：Cell biochemistry and biophysics

authors： Vilin YY,Ruben PC

更新日期：2001-01-01 00:00:00

abstract：:Biomolecular behavior commonly involves complex sets of interacting components that are challenging to understand through solution-based chemical theories. Molecular assembly is especially intriguing in the cellular environment because of its links to cell structure in processes such as chemotaxis. We use a coarse-gra...

journal_title：Cell biochemistry and biophysics

authors： Puskar K,Ta 'asan S,Schwartz R,LeDuc PR

更新日期：2006-01-01 00:00:00

abstract：:The ubiquitous Na+/H+ exchanger NHE1 is regulated by protein phosphorylation events, but the mechanisms involved are incompletely understood. We recently cloned NHE1 from the red blood cells of the winter flounder, Pleuronectes americanus (paNHE1), and demonstrated its activation by osmotic cell shrinkage, beta-adrene...

journal_title：Cell biochemistry and biophysics

authors： Holt ME,King SA,Cala PM,Pedersen SF

更新日期：2006-01-01 00:00:00

abstract：:Definite accurate diagnosis for Creutzfeldt-Jakob disease (CJD) depends on neuropathologic examination of brain biopsy or autopsy. However, transmissible nature makes the invasive examination dangerous. This study was set to determine that the clinical features are for the diagnosis of CJD through a comparison study. ...

journal_title：Cell biochemistry and biophysics

authors： Zhao X,Yu Y,Zhao Z,Xu J

更新日期：2015-06-01 00:00:00

abstract：:Ezrin is overexpressed in a variety of neoplastic cells and is involved in the later stages of tumor progression and metastasis. The present study investigated the expression and functional significance of ezrin in human brain astrocytoma. Ezrin expression was examined in specimens from healthy human brains (10 autops...

journal_title：Cell biochemistry and biophysics

authors： Mao J,Yuan XR,Xu SS,Jiang XC,Zhao XT

更新日期：2013-01-01 00:00:00

abstract：:Osteosarcoma (OS) is the leading primary malignant bone tumor in children and young adults. It is response for a high mortality rate. Nowadays, few researches have been performed on sorafenib against OS and no tools are available to guide the use of sorafenib in the OS treatment. In this study, we aim to investigate t...

journal_title：Cell biochemistry and biophysics

authors： Mei J,Zhu X,Wang Z,Wang Z

更新日期：2014-05-01 00:00:00

abstract：:Neural stem cells (NSCs) have widely been used in the treatment of human neurological disorders as cell therapy via intracerebral or intraventricular infusion. However, the migration mechanism required for NSCs homing and recruitment remains to be elucidated. Recently, SDF-1/CXCR4 axis was shown to be responsible for ...

journal_title：Cell biochemistry and biophysics

authors： Xue L,Wang J,Wang W,Yang Z,Hu Z,Hu M,Ding P

更新日期：2014-12-01 00:00:00

abstract：:Curcumin possesses anti-cancer effects. In the current study, we tested the effect of curcumin on cell proliferation, viability, apoptosis, cell cycle phases, and activation of the PI3K/Akt pathway in the renal cell carcinoma (RCC) cell line RCC-949. We observed that cell proliferation and viability were markedly inhi...

journal_title：Cell biochemistry and biophysics

authors： Zhang H,Xu W,Li B,Zhang K,Wu Y,Xu H,Wang J,Zhang J,Fan R,Wei J

更新日期：2015-12-01 00:00:00

abstract：:Many of the structural domains involved in Ca2+ channel (CACN) inactivation are also involved in determining their sensitivity to antagonist inhibition. We hypothesize that differences in inactivation properties and their structural determinants may suggest candidate domains as targets for the development of novel, se...

journal_title：Cell biochemistry and biophysics

authors： Cox RH,Kathrins M

更新日期：2006-01-01 00:00:00

abstract：:Fibroblasts can be reprogrammed by ectopic expression of reprogramming factors to yield induced pluripotent stem (iPS) cells that are capable of transdifferentiating into diverse types of somatic cell lines. In this study, we examined if functional cardiomyocytes (CMs) can be produced from mouse cardiac fibroblasts (C...

journal_title：Cell biochemistry and biophysics

authors： Jiang B,Dong H,Li Q,Yu Y,Zhang Z,Zhang Y,Wang G,Zhang Z

更新日期：2013-06-01 00:00:00

abstract：:The objective of this study is to explore the incidence of inherited metabolic disorders (IMD) in infants with infantile spasms (IS), with an attempt to improve the early diagnosis and etiological and symptomatic treatment. Urine and blood samples were collected from 60 IS patients and analyzed for the quantification ...

journal_title：Cell biochemistry and biophysics

authors： Liu XM,Li R,Chen SZ,Sang Y,Chen J,Fan CH

更新日期：2015-05-01 00:00:00

abstract：:The role of bone morphogenetic protein 4 (BMP4) in gliomas is not clear. We hypothesized that BMP4 inhibits proliferation in the brain glioma cell line U251 through a signaling pathway involving BMP4 and the mothers against decapentaplegic homolog 4 (SMAD4) protein. We exposed U251 cells to Adriamycin (1 g) for 48 h; ...

journal_title：Cell biochemistry and biophysics

authors： Liu B,Tian D,Yi W,Wu L,Cai Q,Dong H,Shen H,Ji B,Wang L,Zhang S,Ruan D,Chen Q

更新日期：2010-11-01 00:00:00

abstract：:To explore therapeutic effects and underlying mechanism of Salubrinal combined with Ulinastatin (UTI) on acute Paraquat (PQ) poisoning. Four hundred rats were randomly allocated into UTI group, SAL group, SAL + UTI and control group according to random number table with 100 rats in each group. Acute PQ poisoning model...

journal_title：Cell biochemistry and biophysics

authors： Guo H,Jiang C,Sun X

更新日期：2014-12-01 00:00:00

abstract：:Right ventricular hypertrophy and failure are prominent features in cyanotic congenital heart disease, tetralogy of Fallot (TF). Patients with TF require primary cardiac surgery at a very young age. To gain insight into the underlying molecular mechanisms of right ventricular hypertrophy and to identify gene(s) involv...

journal_title：Cell biochemistry and biophysics

authors： Sharma HS,Peters TH,Moorhouse MJ,van der Spek PJ,Bogers AJ

更新日期：2006-01-01 00:00:00

abstract：:The transforming growth factor (TGF) superfamily encompasses about 30 members in mammals. The effect of TGF-beta subfamily members is exerted and regulated via selective pathways of synthesis and signaling that involve activation of latent TGF-beta, specific and high-affinity binding to cell membrane serine/threonine ...

journal_title：Cell biochemistry and biophysics

authors： Camoretti-Mercado B,Solway J

更新日期：2005-01-01 00:00:00

abstract：:A Caulimovirus-based hybrid-promoter, EFCFS, was derived by fusing the distal region (-227 to -54, FUAS) of Figwort mosaic virus full-length transcript promoter (F20) with the core promoter (-151 to +12, FS3CP) domain of Figwort mosaic virus sub-genomic transcript promoter (FS3). The hybrid-promoter (EFCFS) showed enh...

journal_title：Cell biochemistry and biophysics

authors： Ranjan R,Dey N

更新日期：2012-07-01 00:00:00

abstract：:A quality control method of highly diluted and potentized homeopathic remedies is important for curing patients applying homeopathic therapy. Lenger detected photons in highly potentized homeopathic remedies by delayed luminescence. The photons of Argentum metallicum 100MK and Cantharis 100MK magnetically bound to the...

journal_title：Cell biochemistry and biophysics

authors： Lenger K,Bajpai RP,Spielmann M

更新日期：2014-03-01 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used to alleviate pain of the patients who suffer from inflammatory conditions like rheumatoid arthritis, osteoarthritis, and other painful conditions like gout. This class of drugs works by blocking cyclooxgenases which in turn block the prostaglandin prod...

journal_title：Cell biochemistry and biophysics

authors： Zheng L,Du X

更新日期：2014-06-01 00:00:00

abstract：:The objective is to explore the clinical curative effects of methylprednisolone combined with MTX and DXM intrathecal injection in treating neuropsychiatric systemic lupus erythematosus (NPSLE) and its effects on autoantibody level and anti-N-methyl-D-aspartate receptor subtype NR2a/2b antibody (anti-NR2 antibody) lev...

journal_title：Cell biochemistry and biophysics

authors： Wang J,Zhao Y,Zhang J,Lei H,Zhu G,Fu B

更新日期：2014-11-01 00:00:00

abstract：:Bioactive materials present important micro-environmental cues that induce specific intracellular signaling responses which ultimately determine cell behavior. For example, vascular endothelial cells on a normal vessel wall resist inflammation and thrombosis, but the same cells seeded on an artificial vascular graft o...

journal_title：Cell biochemistry and biophysics

authors： Caplan MR,Shah MM

更新日期：2009-01-01 00:00:00

abstract：:Early events in individual hepatocytes of rat activated by adrenaline (10(-6)M) and phenylephrine (10(-5)M) have been investigated by quantitative image microfluorometry and microspectrofluorometry. Cationic DiOC2 and anionic SqSC4 probes have been used for image analysis and transmembrane potential (ΔΨ p) estimation ...

journal_title：Cell biochemistry and biophysics

authors： Kavok NS,Malyukina MY,Borovoy IA,Obukchova EN,Klimov SA

更新日期：2013-11-01 00:00:00

abstract：:The aim of this study was to investigate characteristic CT manifestations of the group of ovarian thecoma-fibroma. 24 patients (26 lesions) presenting with the ovarian thecoma-fibroma were analyzed retrospectively, and the diagnosis were confirmed by pathology after surgery. Our findings included: 22 patients were uni...

journal_title：Cell biochemistry and biophysics

authors： Zhang Z,Wu Y,Gao J

更新日期：2015-03-01 00:00:00

abstract：:In recent studies, sulforaphane (SFN) has been seen to demonstrate antioxidant and anti-tumor activities as well as potent chemopreventive action against cancer. The present study investigates the anti-proliferation (using MTT assay, SFN demonstrated cytotoxic activity against GBM 8401 cell with IC(50) values at 35.52...

journal_title：Cell biochemistry and biophysics

authors： Huang TY,Chang WC,Wang MY,Yang YR,Hsu YC

更新日期：2012-07-01 00:00:00

abstract：:Pro-domain of a cysteine cathepsin contains a highly conserved Ex2Rx2Fx2Nx3Ix3N (ERFNIN) motif. The zymogen structure of cathepsins revealed that the Arg(R) residue of the motif is a central residue of a salt-bridge/H-bond network, stabilizing the scaffold of the pro-domain. Importance of the arginine is also demonstr...

journal_title：Cell biochemistry and biophysics

authors： Aich P,Biswas S

更新日期：2018-06-01 00:00:00

abstract：:Proper administration of antithrombotic and antiplatelet drugs after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) and renal insufficiency is a challenging task. In this study, we utilized Fondaparinux and Tirofiban (either separately or combined) to treat post-PCI patients wi...

journal_title：Cell biochemistry and biophysics

authors： Changjiang H,Jian Q,Yuan Z,Liang Y,Puqing L,Xiaolong G

更新日期：2015-12-01 00:00:00

abstract：:Currently, autologous bone marrow-derived stem cell is one of the most innovative areas of stem cells research. Previous studies on animal models of nervous system diseases have shown that these cells have a good effect on nervous system disorders. The alternative treatment with stem cells for the nervous system disea...

journal_title：Cell biochemistry and biophysics

authors： Ren C,Geng RL,Ge W,Liu XY,Chen H,Wan MR,Geng DQ

更新日期：2014-05-01 00:00:00