Abstract:
:Slow inactivation in voltage-gated sodium channels is a biophysical process that governs the availability of sodium channels over extended periods of time. Slow inactivation, therefore, plays an important role in controlling membrane excitability, firing properties, and spike frequency adaptation. Defective slow inactivation is associated with several diseases of cell excitability, such as hyperkalemic periodic paralysis, myotonia, idiopathic ventricular fibrillation and long-QT syndrome. These associations underscore the physiological importance of this phenomenon. Nevertheless, our understanding of the molecular substrates for slow inactivation is still fragmentary. This review covers the current state of knowledge concerning the molecular underpinnings of slow inactivation, and its relationship with other biophysical processes of voltage-gated sodium channels.
journal_name
Cell Biochem Biophysjournal_title
Cell biochemistry and biophysicsauthors
Vilin YY,Ruben PCdoi
10.1385/CBB:35:2:171subject
Has Abstractpub_date
2001-01-01 00:00:00pages
171-90issue
2eissn
1085-9195issn
1559-0283pii
CBB:35:2:171journal_volume
35pub_type
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