Abstract：
:Biomolecular behavior commonly involves complex sets of interacting components that are challenging to understand through solution-based chemical theories. Molecular assembly is especially intriguing in the cellular environment because of its links to cell structure in processes such as chemotaxis. We use a coarse-grained Monte Carlo simulation to elucidate the importance of spatial constraints in molecular assembly. We have performed a study of actin filament polymerization through this space-aware probabilistic lattice-based model. Quantitative results are compared with nonspatial models and show convergence over a wide parameter space, but marked divergence over realistic levels corresponding to macromolecular crowding inside cells and localized actin concentrations found at the leading edge during cell motility. These conclusions have direct implications for cell shape and structure, as well as tumor cell migration.
journal_name
Cell Biochem Biophysjournal_title
Cell biochemistry and biophysicsauthors
Puskar K,Ta 'asan S,Schwartz R,LeDuc PRdoi
10.1385/cbb:45:2:195subject
Has Abstractpub_date
2006-01-01 00:00:00pages
195-201issue
2eissn
1085-9195issn
1559-0283pii
CBB:45:2:195journal_volume
45pub_type
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