Abstract：
:The transforming growth factor (TGF) superfamily encompasses about 30 members in mammals. The effect of TGF-beta subfamily members is exerted and regulated via selective pathways of synthesis and signaling that involve activation of latent TGF-beta, specific and high-affinity binding to cell membrane serine/threonine kinase receptors, activation of intracellular cascades that include Smad molecules and mitogen-activated protein kinases, and regulated termination of the effect by diverse mechanisms including protein degradation and transcriptional activation. Several comprehensive reviews on TGF-beta biology in general and on the role of this cytokine in other diseases have been published recently. In recent years an unexpected role of TGF-beta on lung homeostasis has been revealed. Here, we discuss the contribution of TGF-beta to the pathogenesis of asthma and chronic obstructive pulmonary disease, two common illnesses of the lung, as well as of lymphangioleiomyomatosis, a rare disease in women. The information we collate and integrate places TGF-beta at a pivotal point within complex networks that control lung physiology as well as the physiopathology of these lung diseases.
journal_name
Cell Biochem Biophysjournal_title
Cell biochemistry and biophysicsauthors
Camoretti-Mercado B,Solway Jdoi
10.1385/CBB:43:1:131subject
Has Abstractpub_date
2005-01-01 00:00:00pages
131-48issue
1eissn
1085-9195issn
1559-0283pii
CBB:43:1:131journal_volume
43pub_type
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journal_title：Cell biochemistry and biophysics
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