Quercetin potentiates the antitumor activity of rituximab in diffuse large B-cell lymphoma by inhibiting STAT3 pathway.

Abstract:

:STAT3 pathway plays an important role in the growth of diffuse large B-cell lymphoma (DLBCL) cells. Here we investigated the antitumor activity of Quercetin, a flavonoid compound, in combination with rituximab in DLBCL cell lines in vitro. We found that Quercetin synergistically enhanced rituximab-induced growth inhibition and apoptosis in DLBCL cell lines. Moreover, we found Quercetin exerted inhibitory activity against STAT3 pathway and downregulated the expression of survival genes. These results suggest that combining the Quercetin with rituximab may present an attractive and potentially effective way for the treatment of DLBCL.

journal_name

Cell Biochem Biophys

authors

Li X,Wang X,Zhang M,Li A,Sun Z,Yu Q

doi

10.1007/s12013-014-0064-8

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

1357-62

issue

2

eissn

1085-9195

issn

1559-0283

journal_volume

70

pub_type

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