Abstract:
:STAT3 pathway plays an important role in the growth of diffuse large B-cell lymphoma (DLBCL) cells. Here we investigated the antitumor activity of Quercetin, a flavonoid compound, in combination with rituximab in DLBCL cell lines in vitro. We found that Quercetin synergistically enhanced rituximab-induced growth inhibition and apoptosis in DLBCL cell lines. Moreover, we found Quercetin exerted inhibitory activity against STAT3 pathway and downregulated the expression of survival genes. These results suggest that combining the Quercetin with rituximab may present an attractive and potentially effective way for the treatment of DLBCL.
journal_name
Cell Biochem Biophysjournal_title
Cell biochemistry and biophysicsauthors
Li X,Wang X,Zhang M,Li A,Sun Z,Yu Qdoi
10.1007/s12013-014-0064-8subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1357-62issue
2eissn
1085-9195issn
1559-0283journal_volume
70pub_type
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