Combined hepatocellular-cholangiocarcinoma with fever of unknown origin: a case report and review of literature.


:Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is a rare form of primary liver cancer (PLC). It is difficult to make a correct preoperative diagnosis of cHCC-CC because of the lack of special features of the disease. We here present a case of a 68-year-old man who presented with fluctuant fever, chills, and sweating and was eventually diagnosed as cHCC-CC after surgery. The tumor was 6.0 cm in diameter with distinct borders and no satellite lesions or lymph nodes were observed during macroscopic examination of the resection specimen. The fever resolved in the postoperative period till the 28th day after surgery, when the patient developed extensive abdominal metastases and died shortly after. More attention should be paid to the patient with PLC showing abnormal features such as FUO, normal range of tumor markers, atypical imaging, and less cirrhosis. Hepatic resection is the treatment of choice although with short-term outcomes.


Cell Biochem Biophys


E C,Xie Y,Yang Y,Ji D,Li W,Zhang X




Has Abstract


2014-05-01 00:00:00












  • Ion exchangers mediating NaCl transport in the renal proximal tubule.

    abstract::We have studied the mechanisms of NaCl transport in the mammalian proximal tubule. Studies of isolated brush-border membrane vesicles confirmed the presence of Na+-H+ exchange and identified Cl(-)-formate and Cl(-)-oxalate exchangers as possible mechanisms of uphill Cl- entry. We found that formate and oxalate each st...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,评审


    authors: Aronson PS

    更新日期:2002-01-01 00:00:00

  • The Role of Arachidonic Acid Metabolism in Myocardial Ischemia-Reperfusion Injury.

    abstract::Patients with myocardial ischemic diseases or who are undergoing one of various heart treatments, such as open heart surgery, coronary artery bypass grafting, percutaneous coronary artery intervention or drug thrombolysis, face myocardial ischemia-reperfusion injury (MIRI). However, no effective treatment is currently...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,评审


    authors: Zhang C,He M,Ni L,He K,Su K,Deng Y,Li Y,Xia H

    更新日期:2020-09-01 00:00:00

  • Analgesic Effect of Intrathecal Administration of Chemokine Receptor CCR2 Antagonist is Related to Change in Spinal NR2B, nNOS, and SIGIRR Expression in Rat with Bone Cancer Pain.

    abstract::The purpose of this study is to investigate the analgesic effect of intrathecal injection of chemokine receptor CCR2 antagonist RS102895, and its effect on spinal expression of N-methyl-D-aspartate (NMDA) receptor NR2B subunit, neuronal nitric oxide synthase (nNOS), and SIGIRR in a rat model of bone cancer pain (BCP)....

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Ren F,Jiao H,Cai H

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  • IP-10/CXCR3 Axis Promotes the Proliferation of Vascular Smooth Muscle Cells through ERK1/2/CREB Signaling Pathway.

    abstract::Excessive proliferation of vascular smooth muscle cells is one of the main pathological processes leading to atherosclerosis and intimal hyperplasia after vascular interventional therapy. Our previous study has shown that interferon-γ inducible protein-10 contributes to the proliferation of vascular smooth muscle cell...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Wang HJ,Zhou Y,Liu RM,Qin YS,Cen YH,Hu LY,Wang SM,Hu ZJ

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  • Clinical application of a dendritic cell vaccine raised against heat-shocked glioblastoma.

    abstract::Establishment of a detection platform for glioblastoma-dendritic cell (DC) vaccine preparation and to determine the efficacy of the vaccine in a clinical trial. Autologous glioblastoma-DC vaccine was prepared from a glioblast specimen procured from surgical resection. The specimen was used to enrich the vaccine with p...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Jie X,Hua L,Jiang W,Feng F,Feng G,Hua Z

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  • Insulin receptors and downstream substrates associate with membrane microdomains after treatment with insulin or chromium(III) picolinate.

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    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Al-Qatati A,Winter PW,Wolf-Ringwall AL,Chatterjee PB,Van Orden AK,Crans DC,Roess DA,Barisas BG

    更新日期:2012-04-01 00:00:00

  • CT diagnosis in the thecoma-fibroma group of the ovarian stromal tumors.

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    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Zhang Z,Wu Y,Gao J

    更新日期:2015-03-01 00:00:00

  • A proteomic analysis of placental trophoblastic cells in preeclampsia-eclampsia.

    abstract::To explore the proteomic changes of placental trophoblastic cells in preeclampsia-eclampsia (PE), placental trophoblastic cells from normally pregnant women and women with hypertension during gestational period were prepared by laser capture microdissection (LCM), and proteins isolated from these cells were subjected ...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Ma K,Jin H,Hu R,Xiong Y,Zhou S,Ting P,Cheng Y,Yang Y,Yang P,Li X

    更新日期:2014-06-01 00:00:00

  • Translating biomaterial properties to intracellular signaling.

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    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,评审


    authors: Caplan MR,Shah MM

    更新日期:2009-01-01 00:00:00

  • Introducing a New Model of Sweet Taste Receptor, a Class C G-protein Coupled Receptor (C GPCR).

    abstract::The structure of sweet taste receptor (STR), a heterodimer of class C G-protein coupled receptors comprising T1R2 and T1R3 molecules, is still undetermined. In this study, a new enhanced model of the receptor is introduced based on the most recent templates. The improvement, stability, and reliability of the model are...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Kashani-Amin E,Sakhteman A,Larijani B,Ebrahim-Habibi A

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  • Single Active Site Mutation Causes Serious Resistance of HIV Reverse Transcriptase to Lamivudine: Insight from Multiple Molecular Dynamics Simulations.

    abstract::Molecular dynamics simulations, binding free energy calculations, principle component analysis (PCA), and residue interaction network analysis were employed in order to investigate the molecular mechanism of M184I single mutation which played pivotal role in making the HIV-1 reverse transcriptase (RT) totally resistan...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Moonsamy S,Bhakat S,Walker RC,Soliman ME

    更新日期:2016-03-01 00:00:00

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    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Sun L,Wang L,Jiang M,Huang J,Lin H

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  • Fluorescence spectroscopy of single photosynthetic light-harvesting supramolecular systems.

    abstract::Recent spectroscopic studies of photosynthetic light-harvesting supramolecular complexes at the single supramolecule level are reviewed. This report describes the "single-molecule" investigation on light-harvesting complex 2 (LH2) of purple photosynthetic bacteria, phycobiliproteins of cyanobacteria and red algae, lig...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,评审


    authors: Saga Y,Tamiaki H

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    abstract::A quality control method of highly diluted and potentized homeopathic remedies is important for curing patients applying homeopathic therapy. Lenger detected photons in highly potentized homeopathic remedies by delayed luminescence. The photons of Argentum metallicum 100MK and Cantharis 100MK magnetically bound to the...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Lenger K,Bajpai RP,Spielmann M

    更新日期:2014-03-01 00:00:00

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    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Murai MJ,Carneiro FR,Gozzo FC,Ierardi DF,Pertinhez TA,Zanchin NI

    更新日期:2006-01-01 00:00:00

  • Hypoxic Preconditioning Combined with Microbubble-Mediated Ultrasound Effect on MSCs Promote SDF-1/CXCR4 Expression and its Migration Ability: An In Vitro Study.

    abstract::Our objective is to investigate the promoting effect of hypoxic preconditioning combined with microbubble (MB)-mediated ultrasound (US) on the SDF-1/CXCR4 expression and the migration ability of mesenchymal stem cells (MSCs). Based on the uniform design, the parameters of MB-mediated US, such as the total treatment ti...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Li L,Wu S,Li P,Zhuo L,Gao Y,Xu Y

    更新日期:2015-12-01 00:00:00

  • Expression and characterization of deletion recombinants of two cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE-3).

    abstract::cDNAs encoding two PDE-3 or cyclic GMP-inhibited (cGI) cyclic nucleotide phosphodiesterase (PDE) isoforms, RPDE-3B (RcGIP1) and HPDE-3A (HcGIP2), were cloned from rat (R) adipose tissue and human (H) heart cDNA libraries. Deletion and N- and C-terminal truncation mutants were expressed in Escherichia coli in order to ...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: He R,Komas N,Ekholm D,Murata T,Taira M,Hockman S,Degerman E,Manganiello VC

    更新日期:1998-01-01 00:00:00

  • Comparative efficacy and safety of drug-eluting stent and conventional therapies in coronary heart disease patients with in-stent restenosis: a meta-analysis.

    abstract::We performed a meta-analysis to compare therapeutic outcome/safety of drug-eluting stent (DES) and conventional in-stent restenosis (ISR) treatments. We browsed through large volume of clinical data by searching MEDLINE, EMBASE, Cochrane central register of controlled trials, and EBSCO databases. In this study, 11 ran...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,meta分析


    authors: Sun Y,Li L,Su Q,Lu Y

    更新日期:2014-01-01 00:00:00

  • Alteration in the balance of prosurvival and proapoptotic signalling pathways leads to sequence-dependent synergism between docetaxel and sorafenib in human non-small cell lung cancer cell lines.

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    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: He X,Zhang T

    更新日期:2014-03-01 00:00:00

  • Determination of DNA damage in experimental liver intoxication and role of N-acetyl cysteine.

    abstract::The present study aimed at detecting DNA damage and fragmentation as well as histone acetylation depending on oxidative stress caused by CCl4 intoxication. Also, the protective role of N-acetyl cysteine, a precursor for GSH, in DNA damage is investigated. Sixty rats were used in this study. In order to induce liver to...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Aksit H,Bildik A

    更新日期:2014-11-01 00:00:00

  • Highly Conserved Arg Residue of ERFNIN Motif of Pro-Domain is Important for pH-Induced Zymogen Activation Process in Cysteine Cathepsins K and L.

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    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Aich P,Biswas S

    更新日期:2018-06-01 00:00:00

  • Association with leptin gene C.-2548 G>A polymorphism, serum leptin levels, and body mass index in Turkish obese patients.

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    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Sahin DS,Tumer C,Demir C,Celik MM,Celik M,Ucar E,Gunesacar R

    更新日期:2013-03-01 00:00:00

  • Endocardial endothelial cells stimulate proliferation and collagen synthesis of cardiac fibroblasts.

    abstract::Given that vascular endothelial cells play an important role in the modulation of vascular structure and function, we hypothesized that endocardial endothelial cells (EECs) may have a modulator role in regulating the cardiac interstitial cells. Endocardial endothelial cells were isolated from freshly collected pig hea...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Kuruvilla L,Nair RR,Umashankar PR,Lal AV,Kartha CC

    更新日期:2007-01-01 00:00:00

  • MT2A Promotes Oxaliplatin Resistance in Colorectal Cancer Cells.

    abstract::We aimed to understand the molecular mechanism underlying the incidence of Oxaliplatin resistance in colorectal cancer. The Oxaliplatin-resistant (OR) HT29 colorectal cell line was established by long-term exposure to Oxaliplatin. Cell viability and proliferation were determined by the 3-(4,5-dimethyl thiazol-2-yl)-2,...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Zhao Z,Zhang G,Li W

    更新日期:2020-12-01 00:00:00

  • Mechanical induction of BMP-7 in osteocyte blocks glucocorticoid-induced apoptosis through PI3K/AKT/GSK3β pathway.

    abstract::Mechanical loading is known to promote osteocyte survival, whereas glucocorticoid treatment results in osteocyte apoptosis. Here, we report that BMP-7, which was secreted by osteocyte in response to mechanical loading, exerts anti-apoptotic effect against dexamethasone-induced apoptosis of osteocytes. We further show ...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Wang Z,Guo J

    更新日期:2013-11-01 00:00:00

  • Acute adaptations of the coronary circulation to exercise.

    abstract::Coronary blood flow is tightly coupled to myocardial oxygen consumption to maintain a consistently high level of myocardial oxygen extraction. This tight coupling has been proposed to depend on periarteriolar oxygen tension, signals released from cardiomyocytes (adenosine acting on K+(ATP) channels), and/or the endoth...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,评审


    authors: Duncker DJ,Merkus D

    更新日期:2005-01-01 00:00:00

  • Extracting the stepping dynamics of molecular motors in living cells from trajectories of single particles.

    abstract::Molecular motors are responsible of transporting a wide variety of cargos in the cytoplasm. Current efforts are oriented to characterize the biophysical properties of motors in cells with the aim of elucidating the mechanisms of these nanomachines in the complex cellular environment. In this study, we present an algor...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Bruno A,Bruno L,Levi V

    更新日期:2013-01-01 00:00:00

  • Theoretical and experimental investigation of calcium-contraction coupling in airway smooth muscle.

    abstract::We investigated theoretically and experimentally the Ca2+-contraction coupling in rat tracheal smooth muscle. [Ca2+]i, isometric contraction and myosin light chain (MLC) phosphorylation were measured in response to 1 mM carbachol. Theoretical modeling consisted in coupling a model of Ca2+-dependent MLC kinase (MLCK) a...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Mbikou P,Fajmut A,Brumen M,Roux E

    更新日期:2006-01-01 00:00:00

  • Extremely high frequency electromagnetic radiation enforces bacterial effects of inhibitors and antibiotics.

    abstract::The coherent electromagnetic radiation (EMR) of the frequency of 51.8 and 53 GHz with low intensity (the power flux density of 0.06 mW/cm(2)) affected the growth of Escherichia coli K12(lambda) under fermentation conditions: the lowering of the growth specific rate was considerably (approximately 2-fold) increased wit...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章


    authors: Tadevosyan H,Kalantaryan V,Trchounian A

    更新日期:2008-01-01 00:00:00

  • Calcium channel gamma subunits: a functionally diverse protein family.

    abstract::The calcium channel gamma subunits comprise an eight-member protein family that share a common topology consisting of four transmembrane domains and intracellular N- and C-termini. Although the first gamma subunit was identified as an auxiliary subunit of a voltage-dependent calcium channel, a review of phylogenetic, ...

    journal_title:Cell biochemistry and biophysics

    pub_type: 杂志文章,评审


    authors: Chen RS,Deng TC,Garcia T,Sellers ZM,Best PM

    更新日期:2007-01-01 00:00:00