Chemopreventive Effects of Azadirachta indica on Cancer Marker Indices and Ultrastructural Changes During 1,2-Dimethylhydrazine-Induced Colon Carcinogenesis in Rats.

abstract：:cDNAs encoding two PDE-3 or cyclic GMP-inhibited (cGI) cyclic nucleotide phosphodiesterase (PDE) isoforms, RPDE-3B (RcGIP1) and HPDE-3A (HcGIP2), were cloned from rat (R) adipose tissue and human (H) heart cDNA libraries. Deletion and N- and C-terminal truncation mutants were expressed in Escherichia coli in order to ...

journal_title：Cell biochemistry and biophysics

authors： He R,Komas N,Ekholm D,Murata T,Taira M,Hockman S,Degerman E,Manganiello VC

更新日期：1998-01-01 00:00:00

abstract：:Biguanides, used for anti-diabetic drugs, bring more attention in cancer research for their beneficial effects. Phenformin is more potent than metformin. However its potential application as a anti-cancer regent is far behind metformin. In order to investigate any beneficial effect of combination of Phenformin and rad...

journal_title：Cell biochemistry and biophysics

authors： Wang J,Xia S,Zhu Z

更新日期：2015-03-01 00:00:00

abstract：:The study analyzed how enteral ecoimmunonutrition, which comprises probiotics, glutamine, fish oil, and Enteral Nutritional Suspension (TPF), can impact on the enteral permeability and serum Ghrelin activity in severe cerebral stroke patients with lung infection. Among 190 severe cerebral stroke patients with toleranc...

journal_title：Cell biochemistry and biophysics

authors： Xu XD,Shao F

更新日期：2015-01-01 00:00:00

abstract：:The overview demonstrates how the use of only one physico-chemical approach, viz., the electron paramagnetic resonance method, allowed detection and identification of dinitrosyl iron complexes with thiol-containing ligands in various animal and bacterial cells. These complexes are formed in biological objects in the p...

journal_title：Cell biochemistry and biophysics

authors： Vanin AF

更新日期：2018-06-01 00:00:00

abstract：:Human salivary aldehyde dehydrogenase (hsALDH) enzyme appears to be the first line of defense in the body against exogenous toxic aldehydes. However till date much work has not been done on this important member of the ALDH family. In this study, we have purified hsALDH to homogeneity by diethylaminoethyl-cellulose (D...

journal_title：Cell biochemistry and biophysics

authors： Alam MF,Laskar AA,Choudhary HH,Younus H

更新日期：2016-09-01 00:00:00

abstract：:Surfactin, purified from Bacillus subtilis natto TK-1, inhibited proliferation of human breast cancer MCF-7 cells in a dose- and time-dependent manner, with IC(50) at 24, 48, and 72 h of 82.6, 27.3, and 14.8 microM, respectively. Surfactin-induced cell death was considered to be apoptotic by observing the typical apop...

journal_title：Cell biochemistry and biophysics

authors： Cao X,Wang AH,Jiao RZ,Wang CL,Mao DZ,Yan L,Zeng B

更新日期：2009-01-01 00:00:00

abstract：:We aimed to understand the molecular mechanism underlying the incidence of Oxaliplatin resistance in colorectal cancer. The Oxaliplatin-resistant (OR) HT29 colorectal cell line was established by long-term exposure to Oxaliplatin. Cell viability and proliferation were determined by the 3-(4,5-dimethyl thiazol-2-yl)-2,...

journal_title：Cell biochemistry and biophysics

authors： Zhao Z,Zhang G,Li W

更新日期：2020-12-01 00:00:00

abstract：:Either the role of the adaptive immune system or the interaction between innate and adaptive immune systems in familial Mediterranean fever (FMF) is not clear so far. So, we planned to search for the interaction between the innate and adaptive immune systems in the pathogenesis of FMF by investigating polymorphism for...

journal_title：Cell biochemistry and biophysics

authors： Gunesacar R,Erken E,Dinkci S

更新日期：2013-03-01 00:00:00

abstract：:The prevalence of cardiovascular disease (CVD) is increasing dramatically especially in developing countries like India. CVD is a leading cause of morbidity and mortality. There has been a growing awareness of the role of nutrients in the prevention of CVD. One specific recommendation in the battle against CVD is the ...

journal_title：Cell biochemistry and biophysics

authors： Cao Y,Lu L,Liang J,Liu M,Li X,Sun R,Zheng Y,Zhang P

更新日期：2015-05-01 00:00:00

abstract：:Phyllanthus sellowianus extracts have been used in Argentina since colonial times in the treatment of diabetes. The in vitro biorheological and hemoagglutinant action of different extracts of P. sellowianus bark on human erythrocytes (RBC) were studied. RBCs were incubated in vitro with four aqueous extracts: Macerati...

journal_title：Cell biochemistry and biophysics

authors： Buszniez P,Di Sapio O,Riquelme B

更新日期：2014-11-01 00:00:00

abstract：:Nutritional changes can affect either the assembly or disassembly of yeast peroxisomes. In the past decade, insights regarding the molecular mechanisms of peroxisome assembly have been gained chiefly through the cloning of the PEX genes obtained by complementation of corresponding pex mutants in several yeast strains ...

journal_title：Cell biochemistry and biophysics

authors： Sakai Y,Subramani S

更新日期：2000-01-01 00:00:00

abstract：:Osteosarcoma (OS) is the leading primary malignant bone tumor in children and young adults. It is response for a high mortality rate. Nowadays, few researches have been performed on sorafenib against OS and no tools are available to guide the use of sorafenib in the OS treatment. In this study, we aim to investigate t...

journal_title：Cell biochemistry and biophysics

authors： Mei J,Zhu X,Wang Z,Wang Z

更新日期：2014-05-01 00:00:00

abstract：:Bortezomib is effective in the therapy of multiple myeloma (MM), but causes infections that are different from those associated with conventional chemotherapy. It is important to identify the risk factors that facilitate infections associated with bortezomib therapy. In the present report, we sought to (1) define the ...

journal_title：Cell biochemistry and biophysics

authors： Li J,Li Y,Huang B,Zheng D,Chen M,Zhou Z

更新日期：2015-01-01 00:00:00

abstract：:The three-dimensional structure of the saccharopine reductase enzyme from the budding yeast Saccharomyces cerevisiae was determined to 1.7-A resolution in the apo form by using molecular replacement. The enzyme monomer consists of three domains: domain I is a variant of the Rossmann fold, domain II folds into a alpha/...

journal_title：Cell biochemistry and biophysics

authors： Andi B,Cook PF,West AH

更新日期：2006-01-01 00:00:00

abstract：:The ubiquitous Na+/H+ exchanger NHE1 is regulated by protein phosphorylation events, but the mechanisms involved are incompletely understood. We recently cloned NHE1 from the red blood cells of the winter flounder, Pleuronectes americanus (paNHE1), and demonstrated its activation by osmotic cell shrinkage, beta-adrene...

journal_title：Cell biochemistry and biophysics

authors： Holt ME,King SA,Cala PM,Pedersen SF

更新日期：2006-01-01 00:00:00

abstract：:Promotion of apoptosis (which is frequently dependent on functional p53) is thought to be critical for the effectiveness of chemotherapy or radiotherapy. Studies in this as well as other laboratories have demonstrated that breast tumor cells are relatively refractory to apoptosis in response to modalities that induce ...

journal_title：Cell biochemistry and biophysics

authors： Gewirtz DA,Sundaram S,Magnet KJ

更新日期：2000-01-01 00:00:00

abstract：:Insulin increases glucose uptake and metabolism in skeletal muscle by signal transduction via protein phosphorylation cascades. Insulin action on signal transduction is impaired in skeletal muscle from Type 2 diabetic subjects, underscoring the contribution of molecular defects to the insulin resistant phenotype. This...

journal_title：Cell biochemistry and biophysics

authors： Karlsson HK,Zierath JR

更新日期：2007-01-01 00:00:00

abstract：:Resveratrol (RSV) is known for its antioxidant properties; however, this compound has been proposed to have cytotoxic and pro-oxidant effects depending on its concentration and time of exposure. We previously reported the cell cycle arrest effect of low doses of RSV in GRX cells, an activated hepatic stellate cell mod...

journal_title：Cell biochemistry and biophysics

authors： Martins LA,Coelho BP,Behr G,Pettenuzzo LF,Souza IC,Moreira JC,Borojevic R,Gottfried C,Guma FC

更新日期：2014-03-01 00:00:00

abstract：:In this study, our aim was to assess the coronary flow reserve (CFR) by performing the adenosine stress (99m)Tc-MIBI single-photon computed tomographic (SPECT) myocardial perfusion imaging in patients with hypertension. 47 hypertensive patients with normal coronary angiography were divided into 2 groups, defined by th...

journal_title：Cell biochemistry and biophysics

authors： Fu Q,Zhang Q,Lu W,Wang Y,Huang Y,Wang Y,Wu Q,Lu C

更新日期：2015-11-01 00:00:00

abstract：:The aim is to study the anticancer effect of CXCR4 gene knockdown by CXCR4-siRNA in nude mice model of ovarian cancer. Injecti the SW626 tumor cells which had been transfected by vectors to make nude mouse model of ovarian cancer. The model mice were divided into interference group, negative control group, and blank c...

journal_title：Cell biochemistry and biophysics

authors： Liu W,Wang Y,Wang H,Wang A

更新日期：2014-12-01 00:00:00

abstract：:In recent studies, sulforaphane (SFN) has been seen to demonstrate antioxidant and anti-tumor activities as well as potent chemopreventive action against cancer. The present study investigates the anti-proliferation (using MTT assay, SFN demonstrated cytotoxic activity against GBM 8401 cell with IC(50) values at 35.52...

journal_title：Cell biochemistry and biophysics

authors： Huang TY,Chang WC,Wang MY,Yang YR,Hsu YC

更新日期：2012-07-01 00:00:00

abstract：:Curcumin is a yellow-orange dye widely used as a spice, food coloring and food preservative. It also exhibits a broad range of therapeutic effects against different disorders such as cancer, diabetes, or neurodegenerative diseases. As a compound insoluble in water curcumin accumulates in cell membranes and due to this...

journal_title：Cell biochemistry and biophysics

authors： Duda M,Cygan K,Wisniewska-Becker A

更新日期：2020-06-01 00:00:00

abstract：:Human copper transporter 1 (hCTR1) is the major high affinity copper influx transporter in mammalian cells that also mediates uptake of the cancer chemotherapeutic agent cisplatin. A low resolution structure of hCTR1 determined by cryoelectron microscopy was recently published. Several protein structure simulation tec...

journal_title：Cell biochemistry and biophysics

authors： Tsigelny IF,Sharikov Y,Greenberg JP,Miller MA,Kouznetsova VL,Larson CA,Howell SB

更新日期：2012-07-01 00:00:00

abstract：:Proper administration of antithrombotic and antiplatelet drugs after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) and renal insufficiency is a challenging task. In this study, we utilized Fondaparinux and Tirofiban (either separately or combined) to treat post-PCI patients wi...

journal_title：Cell biochemistry and biophysics

authors： Changjiang H,Jian Q,Yuan Z,Liang Y,Puqing L,Xiaolong G

更新日期：2015-12-01 00:00:00

abstract：:Danggui Sini decoction (DSD), a famous Chinese medicine, has been used therapeutically in various diseases. In this study, we tried to investigate whether and how DSD could ameliorate myelosuppression in an animal model, in which myelosuppression is induced by cyclophosphamide treatment. The myelosuppression model was...

journal_title：Cell biochemistry and biophysics

authors： Chen QQ,Han X,Wang WM,Zhao L,Chen A

更新日期：2015-03-01 00:00:00

abstract：:Cholesystolithiasis is often associated with common bile duct stones (CBDS). In order to assess the choice of surgery in terms of effectiveness and complications in the treatment of CBDS, we have compared three surgical procedures, viz., laparoscopic choledocholithotomy T-tube drainage (LCH-TD), laparoscopic cholecyst...

journal_title：Cell biochemistry and biophysics

authors： Gu AD,Li XN,Guo KX,Ma ZT

更新日期：2011-04-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) are of great interest for regenerative purposes since they are believed to aid axonal growth. With the view set on the strategies to achieve reconnection between neuronal structures, it is of great importance to characterize the behaviour of these cells on long thread-like structures...

journal_title：Cell biochemistry and biophysics

authors： Pérez-Garnés M,Martínez-Ramos C,Barcia JA,Escobar Ivirico JL,Gómez-Pinedo U,Vallés-Lluch A,Monleón Pradas M

更新日期：2013-01-01 00:00:00

abstract：:Cellular responses to external signals often reflect alterations in gene expression. The activation of cell surface hormone or growth factor receptors upon the binding of appropriate ligands mobilizes signal transduction cascades that can ultimately impact the activity of defined sets of transcription factors. The int...

journal_title：Cell biochemistry and biophysics

authors： DeFranco DB

更新日期：1999-01-01 00:00:00

abstract：:A quality control method of highly diluted and potentized homeopathic remedies is important for curing patients applying homeopathic therapy. Lenger detected photons in highly potentized homeopathic remedies by delayed luminescence. The photons of Argentum metallicum 100MK and Cantharis 100MK magnetically bound to the...

journal_title：Cell biochemistry and biophysics

authors： Lenger K,Bajpai RP,Spielmann M

更新日期：2014-03-01 00:00:00

abstract：:This study describes clinical experience and curative effect of radiophotographically controlled nasointestinal intubation in the treatment of small intestine arrangement in recurrent postoperative adhesive ileus. A 300-cm-long nasointestinal tube was installed into the jejunum through the nasal cavity under radiophot...

journal_title：Cell biochemistry and biophysics

authors： Li RH,Li DC,Lv XP,Quan B

更新日期：2015-06-01 00:00:00