Abstract:
:The calcium channel gamma subunits comprise an eight-member protein family that share a common topology consisting of four transmembrane domains and intracellular N- and C-termini. Although the first gamma subunit was identified as an auxiliary subunit of a voltage-dependent calcium channel, a review of phylogenetic, bioinformatic, and functional studies indicates that they are a functionally diverse protein family. A cluster containing gamma1 and gamma6 conforms to the original description of the protein family as they seem to act primarily as subunits of calcium channels expressed in muscle. Members of a second cluster (gamma2, gamma3, gamma4, gamma8) function as regulators of AMPA receptor localization and function in the brain and are collectively known as TARPs. The function of members of the third cluster (gamma5, gamma7) remains unclear. Our analysis shows that the members of each cluster contain conserved regulatory motifs that help to differentiate the groups. However, the physiological significance of these motifs in many cases remains to be demonstrated.
journal_name
Cell Biochem Biophysjournal_title
Cell biochemistry and biophysicsauthors
Chen RS,Deng TC,Garcia T,Sellers ZM,Best PMdoi
10.1007/s12013-007-0002-0subject
Has Abstractpub_date
2007-01-01 00:00:00pages
178-86issue
2eissn
1085-9195issn
1559-0283pii
CBB:47:2:178journal_volume
47pub_type
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