Abstract:
:Although aggressive therapeutic regimen has been applied in the treatment of Glioblastoma (GBM), the prognosis of patients with GBM remains poor. Preclinical studies have demonstrated the efficacy of Suntinib in GBM both in vitro and in vivo. In this study, we showed that the cytotoxicity was enhanced by transfection with miR-145 mimic. In addition, we suggested that the enhanced cytotoxicity of Sunitinib by miR-145 mimic was mediated by inhibition of both P-gp and Bcrp.
journal_name
Cell Biochem Biophysjournal_title
Cell biochemistry and biophysicsauthors
Liu H,Liu Z,Jiang B,Huo L,Liu J,Lu Jdoi
10.1007/s12013-014-0501-8subject
Has Abstractpub_date
2015-06-01 00:00:00pages
551-7issue
2eissn
1085-9195issn
1559-0283pii
10.1007/s12013-014-0501-8journal_volume
72pub_type
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